Investigating the effectiveness of emotional regulation techniques along with drug therapy on reducing blood pressure, anxiety symptoms, depression and hostility in patients with hypertension compared to drug therapy alone

Objective: Blood pressure-related diseases are the most influenced by psychological factors. The present study was done with the aim of investigating the effectiveness of emotional regulation techniques along with drug therapy on blood pressure reduction, anxiety symptoms, depression and hostility in patients with hypertension compared to drug therapy alone. Materials and Methods: The present study is a quasi-experimental study with pre-test design, post-test design and control group. The population of this study was men and women between the age of 20 to 70 years with hypertension and resident in Tehran province in 2019. Among patients with hypertension referred to Ayatollah Taleghani Training Center Clinic, 30 persons were selected accessibly and were randomly assigned to experimental and control groups. The intervention program of cognitive emotion regulation techniques training was done during 8 sessions in the experimental group. The instruments used in this research were Hospital Anxiety and Depression Scale (HADS) and Spielberger's State-Trait Anger Expression inventory (STAXI). Results: Analysis of covariance showed that there was a significant difference between the experimental and control groups after the intervention in the level of blood pressure, anxiety, depression and total anger expression index at p <0.05 level. Effect size was 0.39, 0.26, 0.21, and 0.21 in depression, anxiety, blood pressure, and total anger expression index, respectively. Conclusion: Specialists in cardiovascular diseases and health psychology area can employ cognitive emotion regulation techniques to improve the physical and psychological problems of individuals with hypertension including blood pressure, anxiety, depression and ange

Discursive Antagonism of Intellectual Discourse and Political Discourse in Determining the Components of Fictional Literature after the Islamic Revolution Based on the Literature of War / Holy Defense

A general overview of the fictional literature after the Islamic Revolution reflects the transformation and formation of a new discourse in the field of critique and creation of literary work. Given that this literature, as a result of the tension between the two political and intellectual discourses, it has its own discourse order. The subject of this paper is the analysis of the tension formed between the dominant political discourse and the intellectual discourse in the field of literary criticism for determining the components of the historical political literature in the period of the Islamic Revolution in the form of the story of the Islamic Revolution and the story of war / Holy Defense based on discourse analysis theory from the perspective of Laclau and Mouffe. Because the analysis of discursive antagonism can explain why and how the path of the fiction literature after the Islamic Revolution is interpreted to achieve the present form, readings of criticisms suggest that in general, the nodal point of war and the Islamic revolution in the intellectual discourse as form and literacy of literature, but in political discourse it is considered as the content and ideological burden of literature. The different articulation of the two discourses is based on the identity of the literature formed after the Islamic Revolution and the war, in the form of floating signifiers such as literary type, character, plot, idea, story time, place of occurrence, and eventually the work of the story can be checked. Also, in light of the acuteness and severity of literature related to intellectual discourse in determining the components of the fiction effect and their application to marginalization of the Holy Defense literature discourse, the literature related to political discourse also has turned to theorize the Holy Defense fiction basics and revise the existing criteria Literary criticism and the introduction of new criteria for the fiction effect

Evaluation the role of nitric oxide in corticosterone effect\'s on anxiety behaviors in mice

Background & Objective: Many evidence indicated that action of glucocorticoid receptors can modulate anxiety behaviors and these effects probably mediated by nitric oxide (NO) system. Thus, in this study, we investigated interaction between corticosterone and NO on anxiety behaviors in mice in elevated plus maze (EPM). Materials & Methods: In this experimental study male albino mice (25-30 g) were used. A standard EPM was used to determine anxiety behaviors. Two behavioral measures were used that include of the percentage of time spent in the open arms and the ratio of open arm entries to total entries during 5 min. Animals received IP injection of L-Name 30 mg/kg as an inhibitor or L-Arginine 50 mg/kg as a synthesis of NO or saline 60 min and corticosterone (1, 2.5, 5 mg/kg) 30 min before of evaluation. Results: Analysis of data indicated that corticosterone at doses of 1 and 2.5, but not 5 mg/kg significantly reduced anxiety behavior in mice (P<0.05). Also pretreatment of L-Name potentiate but injection of L-Arginine had inhibition of corticosterone effects (P<0.05). Conclusion: This study revealed that glucocorticoid induces anxiolytic effects and these effects probably potentiate by NO inhibitor and reduced by NO synthesis. Therefore, it seems that there are interaction between of glucocorticoid and NO system for control of anxiety behaviors

Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder

Background and purpose: Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PTSD. This study aimed at investigating the effects of moderate treadmill exercise and fluoxetine on spatial memory and serum BDNF levels in rat model of PTSD. Materials and methods: In this experimental study, single prolonged stress (SPS) animal model of PTSD was used. Male and female rats were divided into SPS and control groups (n=10 per group). After that, they were subjected to moderate treadmill running (5 days per week/four weeks) and fluoxetine (10 mg/kg/day). Then, behavioral assessment and BDNF measurement were done. Results: SPS male rats showed reduced spatial memory and hippocampal BDNF. Female rats showed more resistance to SPS than male rats. This may be due to the effects of gonadal hormones. The intervention alleviated the SPS-induced alterations in hippocampal-dependent spatial memory and BDNF serum levels in both male and female rats (P<0.05). Conclusion: Combined exercise and fluoxetine administration are more effective in alleviating behavioral and molecular deficits in PTSD patients

Effects of Mineralocorticoid Receptors Blockade on FearMemory Reconsolidation in Rats

Reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization. Previous studies have shown that mineralocorticoid receptors (MRs) modulate distinct phases of learning and memory, which display a high concentration and distinct distribution in the hippocampus. Moreover, we found no studies that examined the role of hippocampal MRs in fear memory reconsolidation. Here, we investigated the effect of MRs blockade on fear memory reconsolidation in rats. Additionally, to test whether blockade of protein synthesis would disrupt fear memory reconsolidation in our paradigm, we tested the effect of cycloheximide, an inhibitor of protein synthesis after memory reactivation. Results indicated that systemic as well as intra-hippocampal administrations of the MR antagonist spironolactone immediately following memory reactivation did not affect on post-retrieval long-term memory. Cycloheximide given after the reactivation treatment produced a strong impairment that persisted over test sessions. These findings indicate that MRs are not required for reconsolidation of fear-based memory

Role of Muscarinic Receptors in Hypoalgesia Induced by Crocin in Neuropathic Pain Rats

Objective. Crocin as an important constituent of saffron has antineuropathic pain properties; however, the exact mechanism of this effect is not known. The aim of this study was whether the hypoalgesic effect of crocin can be exerted through muscarinic receptors. Materials and Methods. In the present project, 36 male Wistar rats (200 ± 20 g) were used. Animals randomly divided into six groups (sham, neuropathy, neuropathy + crocin, neuropathy + atropine 0.5 mg/kg, neuropathy + atropine 1 mg/kg, and neuropathy + atropine 1 mg/kg + crocin). Neuropathy was induced by the chronic constriction injury (CCI) method on the sciatic nerve. Crocin and atropine was administered intraperitoneally during 14 days following the 14th day after surgery. Pain response was detected every three days, two hours after each injection and 3 days following last injection. Mechanical allodynia and thermal hyperalgesia were detected using the Von Frey filaments and plantar test device, respectively. Results. CCI significantly reduced the paw withdrawal response to mechanical and thermal stimulus (P<0.01 and P<0.05, respectively). Crocin therapy significantly reduced mechanical allodynia and thermal hyperalgesia induced by CCI (P<0.05). Atropine pretreatment significantly blocked the hypoalgesic effect of crocin (P<0.05 in mechanical allodynia and P<0.01 in thermal hyperalgesia). Fourteen days administration of atropine alone at a dose of 0.5 mg/kg but not 1 mg/kg significantly reduced CCI-induced mechanical allodynia at day 30 after surgery. Conclusion. Crocin significantly decreased CCI-induced neuropathic pain. The hypoalgesic effect of crocin was blocked by atropine pretreatment, which indicates an important role for muscarinic receptors in the effect of crocin

Protective Effects of Crocus Sativus L. Extract and Crocin against Chronic-Stress Induced Oxidative Damage of Brain, Liver and Kidneys in Rats

Purpose: Chronic stress has been reported to induce oxidative damage of the brain. A few studies have shown that Crocus Sativus L., commonly known as saffron and its active constituent crocin may have a protective effect against oxidative stress. The present work was designed to study the protective effects of saffron extract and crocin on chronic – stress induced oxidative stress damage of the brain, liver and kidneys. Methods: Rats were injected with a daily dose of saffron extract (30 mg/kg, IP) or crocin (30 mg/kg, IP) during a period of 21 days following chronic restraint stress (6 h/day). In order to determine the changes of the oxidative stress parameters following chronic stress, the levels of the lipid peroxidation product, malondialdehyde (MDA), the total antioxidant reactivity (TAR), as well as antioxidant enzyme activities glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase (SOD) were measured in the brain, liver and kidneys tissues after the end of chronic stress. Results: In the stressed animals that receiving of saline, levels of MDA, and the activities of GPx, GR, and SOD were significantly higher (P<0.0001) and the TAR capacity were significantly lower than those of the non--stressed animals (P<0.0001). Both saffron extract and crocin were able to reverse these changes in the stressed animals as compared with the control groups (P<0.05). Conclusion: These observations indicate that saffron and its active constituent crocin can prevent chronic stress–induced oxidative stress damage of the brain, liver and kidneys and suggest that these substances may be useful against oxidative stress