160 research outputs found
Use of Preputial Skin as Cutaneous Graft after Nevus Excision
We report a four-year-old boy with a nevus covering all the plantar side of his second finger on the left foot. He was also affected by congenital phimosis. Surgical excision of the nevus was indicated, but the skin defect would have been too large to be directly closed. The foreskin was taken as a full-thickness skin graft to cover the cutaneous defect of the finger. The graft intake was favourable and provided a functional repair with good aesthetic characteristic
Assessing Mn as an antioxidant agent in bioactive glasses by quantification of catalase and superoxide dismutase enzymatic mimetic activities
The antioxidant activity of Mn as additive in a 45S5 type glass system with and without P2O5 was studied by mimicking the activity of catalase (CMA) and superoxide dismutase (SOD) enzymes. Glasses were melted either under oxidizing or reducing atmosphere (N2/H2) to compare the processing influence on the Mn oxidation state. Thermal (DTA) and optical (UV–Vis) characterizations of the glass powders were carried out to obtain further insight into the structural role of Mn. A correlation of in vitro apatite formation between Tris buffer solution and Simulated Body Fluid (SBF) was performed to optimise Mn substitution, where a decrease in apatite formation was observed by increasing Mn content. Despite this, glasses with up to 1.0 mol% MnO did not show any delay in apatite formation and maintained their CMA and SOD activity. The antioxidant effect of Mn can be attributed to the interconversion Mn2+ ↔ Mn3+ occurring on the glass surface through a heterogeneous catalysis. P2O5 plays an important role in the antioxidant effect of the glass, possibly by charge balancing Mn ions and forming more stable units compared to those formed with Ca and Na. The amount of Mn2+ is predominant in the glass network with respect to Mn3+ in all synthetized glasses. Moreover, glass melting in a reducing atmosphere further avoided Mn oxidation
Supporting info item, In: "Using SHRIMP zircon dating to unravel tectonothermal events in arc environments. The early Palaeozoic arc of NW Iberia revisited"
Dating of zircon cores and rims from granulites developed in a
shear zone provides insights into the complex relationship
between magmatism and metamorphism in the deep roots of
arc environments. The granulites belong to the uppermost
allochthonous terrane of the NW Iberian Massif, which forms
part of a Cambro-Ordovician magmatic arc developed in the
peri-Gondwanan realm. The obtained zircon ages confirm that
voluminous calc-alkaline magmatism peaked around 500 Ma
and was shortly followed by granulite facies metamorphism
accompanied by deformation at c. 480 Ma, giving a time
framework for crustal heating, regional metamorphism, deformation
and partial melting, the main processes that control the
tectonothermal evolution of arc systems. Traces of this arc can
be discontinuously followed in different massifs throughout the
European Variscan Belt, and we propose that the uppermost
allochthonous units of the NW Iberian Massif, together with the
related terranes in Europe, constitute an independent and
coherent terrane that drifted away from northern Gondwana
prior to the Variscan collisional orogenesis
Self-reported oral hygiene habits and periodontal symptoms among postpartum women
Purpose. The purpose of this study is to describe oral hygiene practices and periodontal symptoms among postpartum
women and to assess whether self-reported periodontal symptoms are correlated with a clinical diagnosis of periodontal disease.
Methods A self-administered questionnaire was developed to assess socio-demographic information, oral hygiene habits and frequency of dental visits among a group of 409 postpartum women. Additional questions
included information on self-reported periodontal symptoms.
Pregnancy information was obtained from medical charts.
Results 99.3% of the participants brushed their teeth every day; 46.2 and 53.8% reported teeth brushing once a day or more, respectively. Periodontal disease was present
in 61.4% of women. Patients with gum swelling and tooth mobility were almost twice as likely to have a periodontal
disease (OR 1.7, CI 95% 0.9\u20132.8 and OR 1.7, CI 95%: 0.8\u20133.5, respectively). No associations were found between periodontal disease, gum swelling PTB and/or LBW.
Conclusions Maternal clinical periodontal disease at delivery was related with self-perceived gum swelling and tooth mobility. Dentists and prenatal medical care providers
may have the opportunity to target pregnant women that might be at higher risk for periodontal disease by asking whether they have tooth mobility and/or swollen gum
Preliminary report on endoscopic pilonidal sinus treatment in children: results of a multicentric series.
Effect of Eugenia uniflora and Pagostemon cablin essential oils on Africanized Apis mellifera workers' locomotion.
Conteúdo de lignina e tolerância à deterioração em pré-colheita e efeito na qualidade de sementes de soja
Nusinersen treatment and cerebrospinal fluid neurofilaments : An explorative study on Spinal Muscular Atrophy type 3 patients
The antisense oligonucleotide Nusinersen has been recently licensed to treat spinal muscular atrophy (SMA). Since SMA type 3 is characterized by variable phenotype and milder progression, biomarkers of early treatment response are urgently needed. We investigated the cerebrospinal fluid (CSF) concentration of neurofilaments in SMA type 3 patients treated with Nusinersen as a potential biomarker of treatment efficacy. The concentration of phosphorylated neurofilaments heavy chain (pNfH) and light chain (NfL) in the CSF of SMA type 3 patients was evaluated before and after six months since the first Nusinersen administration, performed with commercially available enzyme-linked immunosorbent assay (ELISA) kits. Clinical evaluation of SMA patients was performed with standardized motor function scales. Baseline neurofilament levels in patients were comparable to controls, but significantly decreased after six months of treatment, while motor functions were only marginally ameliorated. No significant correlation was observed between the change in motor functions and that of neurofilaments over time. The reduction of neurofilament levels suggests a possible early biochemical effect of treatment on axonal degeneration, which may precede changes in motor performance. Our study mandates further investigations to assess neurofilaments as a marker of treatment response
Physiological potential and antioxidant metabolism during storage of soybean seeds contrasting with phenylpropanoid pathway compounds.
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