Effect Of Ginger Extract On Gasoline Associated Immunitoxicities In Wistar Rats

Effect of ginger extracts on gasoline associated immunotoxicities in wistar rats was studied. Fifteen wistar rats were randomly assigned into three study groups. Group 1 was the control, while groups 2 and 3 received daily treatment by inhalation of gasoline vapour. The animals in group3 were also treated with 100mg ginger/kg body weight. The experiment lasted for 60 days. One day after the final exposure, the animals were euthanized by overdose of chloroform. Blood was collected by cardiac puncture into EDTA sterilized sample bottles and used for the analysis of hemoglobin(Hb),packed cell volume(PCV),red blood cells(RBC),white blood cells and erythrocyte indices-mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH),mean corpuscular hemoglobinconcentration(MCHC). The results showed that gasoline alone decreased the levels of Hb, RBC, WBC, PCV, MCV and MCHC, but it had no significant effect on the MCH of the rats. However, treatments with ginger extracts nearcompletely abrogated /mitigated any effects that have been induced by inhalation of gasoline alone. It appears that ginger extracts inhibited the chain reaction, caused by free radicals, and acted to remove the catabolic wastes from the lymphocytes and reticulocytes, thereby accelerating metabolism and lymph drainage. It also appears that gingerextracts promoted the sloughing-off of wasted tissues and corrected the imbalance of elevated inflammatory prostaglandins, leading to increased erythrocytes synthesis and improved immune system

Effect of alchol-kolanut interaction on brain nonoamine oxidase activity in wistar albino rats

No Abstract.Global Journal of Pure and Applied Sciences Vol. 13 (3) 2007: pp.391-39

Syphilis.

Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. T. pallidum is renowned for its invasiveness and immune-evasiveness; its clinical manifestations result from local inflammatory responses to replicating spirochaetes and often imitate those of other diseases. The spirochaete has a long latent period during which individuals have no signs or symptoms but can remain infectious. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Syphilis also causes several hundred thousand stillbirths and neonatal deaths every year in developing nations. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen. Strong advocacy and community involvement are needed to ensure that syphilis is given a high priority on the global health agenda. More investment is needed in research on the interaction between HIV and syphilis in MSM as well as into improved diagnostics, a better test of cure, intensified public health measures and, ultimately, a vaccine