Understanding adult neurogenesis beyond its role in learning and memory formation

There has been a shift in the understanding of brain, neurons, and their functional role over the last two decades. Earlier it was believed that the brain was a static organ and was not subject to any change throughout life. An understanding was developed later that brain reorganizes its structure by a specific property called neuroplasticity. Recent research shows that the brain generates new neurons even in the adult stage, and this process is called adult neurogenesis. Although researchers still not have all the answers about the newborn neurons, and why and how they are generated, and what is their role, some have highlighted the importance of these in learning and memory formation, and even in memories of fear and spatial navigation. A wide range of environmental experience influences the generation of newborn neurons and their functional variability. There are questions about how different environmental experiences cause the differences in the generation of new neurons. Recently the field of optogenetics attempted to answer the questions on adult neurogenesis. However there are still questions about adult neurogenesis which needs a more naturalistic approach, for their better understanding

KAN- YARALANMA FOBİSİ: CİNSİYETE ÖZGÜ BEYİN FARKLILIKLARINA GENEL BAKIŞ

Blood injury injection phobia (BII) involves an intense fear of situations, in which an individual is directly or indirectly exposed to blood, injections or viewing injuries, along with a tendency to avoid these situations. BII phobia is highly prevalent in females as compared to males. It is virtually the only specific phobia and the only anxiety disorder, in which fainting occurs. Although fainting is much distressed to the BII phobic individuals, but it may have developed in the humans at the time when they needed it much as a survival mechanism. In this article we discuss how in the humans there may have developed the trait of BII phobia in the ancestors, including the variation in the symptoms among sexes. There are not studies which specifically examine the syncope related brain differences among genders. But there are other well defined studies which highlight marked differences among male and female brains. Considering this we also review some recent breakthrough discoveries showing differences in the brain of males and females at gene expression level which leads to the variation in brain and behaviour related problems among genders. There is an exigent need to understand the brain behavioral problems through multiple perspectives

Blood Injury and Injection Phobia: The Neglected One

Blood injury and injection (BII) phobia is a unique phobia associated with a diphasic cardiovascular response. The aim of this survey was to report the prevalence of BII phobia, its heritability, and clinical characteristics among the males and females in the Indian subcontinent. An interview and a survey were conducted using a developed BII phobia 21-item questionnaire among 3261 participant males (n=1648) and females (n=1613). Cronbach’ alpha (α) of 0.972 of internal consistency was reported. The prevalence of BII phobia and associated fainting in females was slightly more than double in the males with a significant gender related effect. Similar avoidance behaviours involving hospital visits were reported for both males and females. The relative frequency of BII phobia among first and third degree relatives was found to be higher than among second degree relatives. Depression was found highly comorbid with BII phobia while a low rate of obsessive compulsion disorder (OCD) and social anxiety disorder (SAD) was reported. Morbidity associated with BII phobia may increase dramatically when other medical problems coincide with it

Omega-3 fatty acids and the treatment of depression: a review of scientific evidence

Depression is a condition in which an individual feels lethargic, irritable, and guilty, has difficulty and trouble, no enjoyment in life, mood swings, sometimes suicidal ideation and thoughts, and loss of pleasure in activities. There are hundreds of millions of individuals suffering from major depression disorder all over the world. This leads to a considerable portion of the economy going for treatment as large amounts of money are spent on drugs every year. Pharmaceutical drugs are not very effective and they also have side effects that compound the problem. There are number of studies which shows that omega-3 fatty acids are proving to be very effective against the treatment of major depression disorder and other psychiatric disorders. However, the data regarding the efficacy of omega-3 fatty acids in depression treatment are conflicted. This article reviews the recent research showing the relation between omega-3 fatty acids and depression. The roles of the omega-3 fatty acids in the treatment of depression are being studied with increased pace in the last decade due to heightened prevalence of depression. It is emphasized that omega-3 fatty acids have no record of associated side effects, which deserves greater attention for further research