14 research outputs found
Institutional design and central - locking strategies: introducing the new block grants system in Norway
When special grants are replaced by block grants in a central-funding financing system, central government steering of the communalized welfare sectors can no longer be based on economic incentives. In this paper the potential for central government control over welfare policies under block-grants conditions is discussed, with particular reference to the change in the Norwegian transfers system. It is argued that, given high ambitions for the welfare state at the central level, a central government may find legislation to be an insufficient means of control, and it may be more likely to search for new types of economic incentives to make the communes perform according to the priorities of the national welfare state. In doing so, however, the central government must find methods of legitimizing a partial return to old practices that do not contradict the principle of block grants.
Differential effects of chlorpromazine on secretion, protein phosphorylation and phosphoinositide metabolism in stimulated platelets
Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene.
Recent cloning of a cDNA (UNG15) encoding human uracil-DNA glycosylase (UDG), indicated that the gene product of M(r) = 33,800 contains an N-terminal sequence of 77 amino acids not present in the presumed mature form of M(r) = 25,800. This led to the hypothesis that the N-terminal sequence might be involved in intracellular targeting. To examine this hypothesis, we analysed UDG from nuclei, mitochondria and cytosol by western blotting and high resolution gel filtration. An antibody that recognises a sequence in the mature form of the UNG protein detected all three forms, indicating that they are products of the same gene. The nuclear and mitochondrial form had an apparent M(r) = 27,500 and the cytosolic form an apparent M(r) = 38,000 by western blotting. Gel filtration gave essentially similar estimates. An antibody with specificity towards the presequence recognised the cytosolic form of M(r) = 38,000 only, indicating that the difference in size is due to the presequence. Immunofluorescence studies of HeLa cells clearly demonstrated that the major part of the UDG activity was localised in the nuclei. Transfection experiments with plasmids carrying full-length UNG15 cDNA or a truncated form of UNG15 encoding the presumed mature UNG protein demonstrated that the UNG presequence mediated sorting to the mitochondria, whereas UNG lacking the presequence was translocated to the nuclei. We conclude that the same gene encodes nuclear and mitochondrial uracil-DNA glycosylase and that the signals for mitochondrial translocation resides in the presequence, whereas signals for nuclear import are within the mature protein
Innovations in Ethnic Landscapes: A Study of Innovations in Three Municipalities in Northern Norway
Coping with second home tourism : responses and strategies of private and public service providers in western Sweden
Second homes have increasingly gained academic attention, not least within tourism research. Nevertheless, most studies have addressed the topic from the perspective of the second home owners, highlighting issues such as motivation for second home ownership, use patterns, geographical location, and meanings of second homes. Even the impacts of second homes have mainly been addressed as the accumulated outcome of their owners’ decisions. Hence, second homes have mainly been conceptualized as personal/family projects. Relatively little research has been done on the ways local communities cope with second home tourism. This is the departure point for this paper, with the purpose of analysing coping strategies among public and private stakeholders regarding second home tourism. It is argued that communities have various ways of coping, ranging from resistance to resource utilization. The proposed conceptual framework is empirically applied to the case of the Swedish West Coast. In an interview survey of public and private service providers, different strategies are identified. The results of the survey indicate that second home owners are increasingly seized on as a resource that can be utilized for business development. Ultimately, institutional preconditions imply that second homes remain a challenge for local municipalities