Parental Attitudes to Myopia: a Key Agent of Change for Myopia Control?

Purpose With the increasing prevalence in myopia there is growing interest in active myopia prevention. This study aims to increase our understanding of parental attitudes to myopia development and control, as a means to inform future health planning and policy. It evaluates, for the first time, the attitude of parents to myopia and its associated risks, as well as assessing the exposure of Irish children to environmental factors that may influence their risk profile for myopia development. Methods Parents of 8–13 year old children in eight participating schools completed a questionnaire designed to assess their knowledge of and attitudes towards myopia and its risk factors. A structured diary was also used to capture daily activities of children in relation to myopia risk factors. Results Of 329 parents, just 46% considered that myopia presented a health risk to their children, while an identical number (46%) regarded it as an optical inconvenience. Myopia was also, but less frequently, considered an expense (31% of parents), a cosmetic inconvenience (14% of parents) and, by some, as a sign of intelligence (4% of parents) 76% of parents recognised the potential of digital technology to impact the eye, particularly as a cause of eyestrain and need for spectacles. Only 14% of parents expressed concern should their child be diagnosed with myopia. Compared to non myopic parents, myopic parents viewed myopia as more of an optical inconvenience (p \u3c 0.001), an expense (p \u3c 0.005) and a cosmetic inconvenience (p \u3c 0.001). There was a trend for myopic parents to limit screen time use in their household more than non‐myopic parents (p = 0.05). Parents who considered myopia a health risk sought to limit screen time more than parents who did not regard myopia as a health risk to their child (p = 0.01). Children spent significantly longer performing indoor proximal tasks (255 min) compared to time spent outdoors (180 min; p \u3c 0.0001) daily. Older (p = 0.001), urban (p = 0.0005) myopic (=0.04) children spent significantly more time at digital screens compared to younger non‐myopic children from a rural background. Conclusion Parental attitudes to myopia were typically nonchalant in relation to health risk. This is of particular concern given the impact parents have on children\u27s behaviour and choices with respect to such risk factors, demonstrating an acute need for societal sensitisation to the public health importance of myopia

The Ransom and Sarah Williams Farmstead: Post-Emancipation Transitions of an African American Family in Central Texas Vol. 1

In conjunction with the proposed construction of the southwest segment of State Highway 45 in southern Travis County, the Texas Department of Transportation sponsored archeological testing and data recovery efforts at the Ransom Williams farmstead. Prewitt and Associates, Inc., conducted an interdisciplinary community-based historic archeological study of the farmstead from 2005 through 2011. Extensive archival research reveals that the 45-acre farm was owned and occupied by Ransom Williams and his wife Sarah, both former slaves, from about 1871 to ca. 1905. The Williams family lived in the predominantly white rural community of Bear Creek, but they had connections to the nearby freedmen communities of Antioch Colony in northern Hays County and Manchaca in southern Travis County. The stories of the Ransom Williams family and their connections to these communities are enhanced by extensive oral history research, with over 46 hours of taped and transcribed interviews with 27 descendant community members. Data recovery investigations focused on a landscape archeological study to define the layout and design of the entire farmstead, including a stock pond and a network of dry-laid rock walls that facilitated water drainage, demarcated property boundaries, and formed livestock pens. Intensive hand excavations were used to examine features associated with the Williams house, outbuildings and activity areas, and a large trash midden. This work recovered more than 26,000 artifacts. They constitute an impressive material culture assemblage that is associated, with few exceptions, with the Williams family tenure on the land. The combined archival data, oral history interviews, and archeological evidence tell the fascinating story of how one African American farm family lived and thrived in central Texas during Reconstruction and into the Jim Crow era

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

SummaryMitochondrial respiration is important for cell proliferation; however, the specific metabolic requirements fulfilled by respiration to support proliferation have not been defined. Here, we show that a major role of respiration in proliferating cells is to provide electron acceptors for aspartate synthesis. This finding is consistent with the observation that cells lacking a functional respiratory chain are auxotrophic for pyruvate, which serves as an exogenous electron acceptor. Further, the pyruvate requirement can be fulfilled with an alternative electron acceptor, alpha-ketobutyrate, which provides cells neither carbon nor ATP. Alpha-ketobutyrate restores proliferation when respiration is inhibited, suggesting that an alternative electron acceptor can substitute for respiration to support proliferation. We find that electron acceptors are limiting for producing aspartate, and supplying aspartate enables proliferation of respiration deficient cells in the absence of exogenous electron acceptors. Together, these data argue a major function of respiration in proliferating cells is to support aspartate synthesis

Machinery Purchasing

Discussion Grou

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue culture are much higher than what has been described in vivo. Here, we show that the environment drastically alters sensitivity to metformin and other complex I inhibitors. We find that complex I supports proliferation by regenerating nicotinamide adenine dinucleotide (NAD)+, and metformin's anti-proliferative effect is due to loss of NAD+/NADH homeostasis and inhibition of aspartate biosynthesis. However, complex I is only one of many inputs that determines the cellular NAD+/NADH ratio, and dependency on complex I is dictated by the activity of other pathways that affect NAD+ regeneration and aspartate levels. This suggests that cancer drug sensitivity and resistance are not intrinsic properties of cancer cells, and demonstrates that the environment can dictate sensitivity to therapies that impact cell metabolism. Keywords: cancer metabolism; metformin; biguanide; NAD+/NADH ratio; drug sensitivity; complex I; mitochondria; aspartateNational Institutes of Health (U.S.) (Grant P30CA1405141)National Institutes of Health (U.S.) (Grant GG006413)National Institutes of Health (U.S.) (Grant R01 CA168653)National Institutes of Health (U.S.) (Grant R01 CA201276

Machinery Purchasing

Discussion Grou

Multijurisdictional Approach to Biosurveillance, Kansas City

An electronic reporting system for a network of 22 laboratories was implemented in Kansas City, Missouri, with an independent organization acting as a data clearinghouse between the reporting laboratories and public health departments. The system ran in tandem with conventional reporting methods. Laboratory test orders and results were aggregated and mapped to a common nomenclature. Reports were delivered through a secure Internet connection to the Kansas City Health Department (KCHD); during the first 200 days of operation, 359 qualified results were delivered electronically to KCHD. Data were received more quickly than they were with conventional reporting methods: notification of chlamydia cases arrived 2 days earlier, invasive group A streptococcal disease cases arrived 2.3 days sooner, and salmonellosis cases arrived 2.7 days sooner. Data were more complete for all demographic fields, including address, age, sex, race, and date of birth. Two hundred fourteen cases reported electronically were not received by conventional means

Systematizing Confidence in Open Research and Evidence (SCORE)

Assessing the credibility of research claims is a central, continuous, and laborious part of the scientific process. Credibility assessment strategies range from expert judgment to aggregating existing evidence to systematic replication efforts. Such assessments can require substantial time and effort. Research progress could be accelerated if there were rapid, scalable, accurate credibility indicators to guide attention and resource allocation for further assessment. The SCORE program is creating and validating algorithms to provide confidence scores for research claims at scale. To investigate the viability of scalable tools, teams are creating: a database of claims from papers in the social and behavioral sciences; expert and machine generated estimates of credibility; and, evidence of reproducibility, robustness, and replicability to validate the estimates. Beyond the primary research objective, the data and artifacts generated from this program will be openly shared and provide an unprecedented opportunity to examine research credibility and evidence

Brass Happenings

Presenting a student recital for brass students in USU\u27s Music Department.https://digitalcommons.usu.edu/music_programs/1107/thumbnail.jp