In vitro vascular effects of chloroquine in rat aortic strip preparation

No Abstrac

Anti-inflammatory and Analgesic activities of Methanolic Extracts of the Stem Bark of Alstonia Boneei , Ficus Elastica and Xylopia Aethiopica in Rodents

The analgesic and anti-inflammatory properties of equimolar concentrations of the methanolic extracts of Alstonia Boneei (MEAB), Ficus Elastica (MEFE) and Xylopia Aethiopica (MEXA) were investigated in 0.1% acetic acid induced Pain (Writhing) in Mice , and 0.4ml of 0. 1% carrageenan induced inflammation in rats as a model of acute inflammation and compared with Indomethacin. The MEAB and MEXA at concentrations used did not produce significant or marked inflammatory and analgesic effects while MEFE significantly (p <0.05) inhibited carrageenan induced inflammation and acetic acid induced writhing

Analgesic and toxicological effects of leaf extract of Clerodendrum volubile Linn. in Wistar albino rats

Clerodendrum volubile is commonly found in the Southern part of Nigeria and it is known for its food and medicinal purposes. This study was aimed to investigate the phytochemical constituents and toxicological effects of the leaf extract of C. volubile on Wistar rats. The plant was screened for qualitative and quantitative phyto-constituents using standard procedures. Toxic effect of the plant was determined after a 28-day sub-acute toxicity study in Wistar albino rats of both sexes. Treatment groups received a daily dose of the plant extract at 1, 10, 100 mg/kg, acetaminophen 100 mg/kg, aspirin 100 mg/kg and distilled water as control for 28 days. The toxicity was evaluated by using haematological, histological and biochemical parameters. Alkaloids, saponins, tannins, anthraquinones, phenols and flavonoids were appreciably present in methanol and diethyl-ether extracts when compared with aqueous extract. This study showed no lethality of animals after 28 days. A significant increase in haemoglobin concentration was observed (8.92±0.01 g/dL) when compared with acetaminophen and distilled water. The spleen and heart architectures were normal compared with the standard drugs. The study concludes that the methanol extract of C. volubile showed minimal morphological alterations on various organs examined. Further study is recommended to isolate the active ingredient responsible for its activities

Neuropharmacological Activities of Ficus platyphylla stem bark in mice

Methanol Extract Ficus platyphylla stem bark in dosages (17, 40 and 75, 150mg/kg) was found to produce a profound decrease in exploratory activity in mice, the extract indicated peripheral and central analgesic effects as shown by significant inhibition of acetic acid - induced writhing, and delayed onset in leptazol induced-convulsion (seizures) in mice respectively. It also decreases the rate of leptazol induced mortality in mice. The totality of these effects showed that the extract possesses depressant action on the central nervous system