28 research outputs found

    The disruption of proteostasis in neurodegenerative diseases

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    Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

    Aspectos epidemiológicos de pacientes com lesÔes ungueais e cutùneas causadas por Scytalidium spp Epidemiological aspects of patients with ungual and cutaneous lesions caused by Scytalidium spp

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    FUNDAMENTO: As dermatomicoses causadas por fungos filamentosos nĂŁo dermatĂłfitos sĂŁo infecçÔes raras, exceto as onicomicoses, cuja prevalĂȘncia vem crescendo nos Ășltimos anos. Dentre esses agentes etiolĂłgicos destacam-se o Scytalidium dimidiatum e o S. hyalinum, fungos emergentes responsĂĄveis por micoses em unhas e pele. OBJETIVO: Investigar as caracterĂ­sticas epidemiolĂłgicas das onicomicoses e micoses de outras localizaçÔes causadas pelos fungos do gĂȘnero Scytalidium, utilizando-se como parĂąmetros sexo, idade e localizaçÔes das lesĂ”es. MÉTODOS: Avaliaram-se 81 amostras com cultura positiva para o gĂȘnero em estudo, oriundas de 74 pacientes encaminhados ao LaboratĂłrio de Investigação em Dermatologia (ID) situado na cidade do Rio de Janeiro (RJ), no perĂ­odo de 1997 a 2006. As amostras foram submetidas a confirmação diagnĂłstica por exame direto e cultura. RESULTADOS: A prevalĂȘncia de onicomicoses por Scytalidium spp. foi de 0,87%, entre as idades de 41 e 60 anos (48,64%). Em relação Ă  localização das lesĂ”es, os pĂ©s foram mais acometidos (91,36%), com predomĂ­nio do hĂĄlux esquerdo. No exame direto, as estruturas mais encontradas foram hifas hialinas; na cultura, a espĂ©cie S. dimidiatum foi a mais frequente. CONCLUSÃO: As onicomicoses por Scytalidium spp. sĂŁo raras e o S. dimidiatum foi a espĂ©cie mais isolada neste laboratĂłrio no perĂ­odo em estudo.<br>BACKGROUND: Dermatomycoses caused by non-dermatophyte filamentous fungi are rare infections, except for onychomycosis, whose prevalence has increased over the past few years. Among these etiologic agents, we highlight Scytalidium dimidiatum and S. hyalinum, emergent fungi that cause mycoses that affect the nails and skin. OBJECTIVE: To investigate the characteristics of onychomycosis and other mycoses caused by the fungi Scytalidium spp, using sex, age and site of infection as parameters. METHODS: Eighty-one samples were evaluated showing positive culture for Scytalidium spp, obtained from 74 patients referred to the Laboratory of Investigation in Dermatology (ID) located in the city of Rio de Janeiro, RJ, between 1997 and 2006. The samples were submitted to diagnostic confirmation through direct exam and culture. RESULTS: The prevalence of onychomycosis caused by Scytalidium spp. was of 0,87%. The most prevalent age was between 41-60 years (48.64%). Regarding the site of infection, the feet (91.36%) were most affected, with predominance of the left hallux. Hyaline hyphae were the most common structures in direct examination and the species S. dimidiatum was the most frequent in culture. CONCLUSION: Onychomycosis caused by Scytalidium spp. is rare and S. dimidiatum was the most isolated species in this laboratory during the period of the study

    MR of the kidneys, liver, and spleen in paroxysmal nocturnal hemoglobinuria

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    The magnetic resonance (MR) findings in the liver, kidneys, and spleen in eight patients with paroxysmal nocturnal hemoglobinuria (PNH) were retrospectively reviewed to determine whether characteristic features could be demonstrated. Eight patients underwent abdominal MR examinations by gradient echo sequences (seven patients), spin-echo sequences (seven patients), and inversion recovery (one patient). Signal intensities of the kidneys, liver, and spleen were visually evaluated. Autopsy and liver biopsy correlation were available in one case each. Renal signal intensity was decreased in all eight patients by either gradient-echo or T2-weighted sequences and in the single inversion recovery sequence. Hepatic signal intensity was decreased in three of eight patients on spin- and gradient-echo images. Splenic signal intensity was decreased in three of eight patients on spin- and gradient-echo images, and in two of these was manifest as focal low signal spots (Gamna-Gandy bodies). While the signal intensity in the renal cortex is typically decreased in patients with PNH, signal intensities in the liver and spleen are variable. Low signal intensity in the kidneys is due to hemosiderin deposition resulting from intravascular hemolysis, whereas low signal intensity in the liver or spleen may be due to either transfusion siderosis, or as a consequence of hepatic or portal venous thrombosis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48141/1/261_2004_Article_BF00203497.pd
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