Longitudinal Interviews of Couples Diagnosed with Diminished Ovarian Reserve Undergoing Fragile X Premutation Testing

About 10 % of infertile/subfertile women are diagnosed with diminished ovarian reserve (DOR), of which?<?5 % will become pregnant spontaneously. Fragile X (FMR1) genetic testing may provide a reason for her early ovarian aging and/or have reproductive implications. Seven women with DOR (genetic study subset) and the male partners of six of these women were separately interviewed about the experience of being asked to undergo this unanticipated genetic test. Three interviews were conducted (before, within 1 week after, and 3 months after learning the test results). None of the participants carried the FMR1 premutation (largest FMR1 allele 27–50 CGG repeats). For women, their pregnancy-seeking journey was long and exhausting. Women understood the reproductive implications of carrying the FMR1 premutation, and hoped for a negative result. Being offered a genetic test caused women to pause and re-think their future reproductive plans. Husbands viewed the infertility journey as filled with unknowns, of which the genetic test results would be one more puzzle piece. The expense of fertility testing/treatment was mentioned by both spouses, though more notably by husbands. The introduction of a possible genetic cause of infertility, with additional potential health consequences for future biological children, caused women to re-think their quest for pregnancy. In contrast, the genetic test was viewed as an additional source of information for their husbands as opposed to raising concern regarding potential reproductive ramifications

Code of Ethics of the National Society of Genetic Counselors: Explication of Revisions

The Code of Ethics (COE) of the National Society of Genetic Counselors (NSGC) was adopted in 1992. In 2004, the NSGC leadership appointed the Code of Ethics Work Group (COEWG) to consider revisions to the NSGC COE based on advice from the NSGC legal counsel, and to consider additional changes given growth in the scope of genetic counseling practice since the adoption of the original COE. After input from the NSGC membership, changes to the COE addressing the recommendations of the NSGC legal counsel were approved in December 2004. The COEWG then reviewed ethical codes and codes of professional conduct from 22 professional organizations, deemed to have similar goals and philosophies to the NSGC, searching for themes that encompassed genetic counseling practice that might not yet be addressed in the NSGC COE. Additional revisions to the COE were proposed, and after feedback from the NSGC membership, the revised COE was approved in January 2006 by majority vote of full members of the NSGC. The explications for the 2004 and 2006 revisions are presented

Quadratic reciprocity for the rational integers and the Gaussian integers

This thesis begins by giving a brief time line of the origins of Number Theory. It highlights the big theorems that have been constructed in this subject, along with the mathematicians who constructed them. The thesis, then, goes on to prove the Law of Quadratic Reciprocity for the Jacobi symbol. This includes proving Eisenstein's Lemma for the Jacobi symbol. Then, it is shown that Gauss's Lemma has an even greater generalization than Eisenstein's Lemma. Finally, this thesis shows the similarities between the rational integers and the Gaussian integers, including proving the Law of Quadratic Reciprocity for the Gaussian integers and constructing a similar version of Gauss's Lemma for the Gaussian integers

Attitudes and Practice of Genetic Counselors Regarding Anonymous Testing for BRCA1/2.

Patients and clinicians alike view anonymous testing as a potential way to avoid perceived risks of genetic testing such as insurance and employment discrimination and the potential loss of privacy. To assess their experience with and attitudes towards anonymous testing for BRCA1/2, genetic counselors were invited to complete an internet-based survey via the NSGC Familial Cancer Risk Counseling Special Interest Group (FCRC-SIG) listerv. A majority of the 115 respondents (70%) had received requests from patients for anonymous BRCA1/2 testing at some point in their careers and 43% complied with this request. Most counselors, however, encountered such requests infrequently, 1–5 times per year. Although genetic counselors do not generally encourage anonymous testing and over a third of respondents feel it should never be offered, a substantial subset support its use under specific circumstances. In general, a strong consensus exists among counselors that anonymous testing should not be offered routinely. In light of the current legislative landscape, it is of note that a substantial proportion of respondents (42.7%) cited the threat of life insurance discrimination as a reason for pursuing AT, and fewer cited health insurance (30.0%) or employment discrimination (29.1%) as justifications. Since there exists no federal legislative protections against discrimination by life insurance companies, it makes sense that genetic counselors were more responsive to this issue as opposed to the threat of discrimination in health insurance and employment

An evaluation of the adequacy of diets planned in a home management house

The dietary habits of college women have increasingly interested dietitians, nutritionists and research workers for the past half-century. Food habits at college depend upon home dietary practices more or less modified by the influence of knowledge gained in college. The data for this study were obtained from the records kept at one of the home management houses on the campus of the Woman's College of the University of North Carolina, at Greensboro, North Carolina. The occupants of the house were home economics seniors whose food habits would be expected to show the influence of four years of training in home economics. They averaged twenty-one years of age and 126 pounds in weight. The students came from middle class homes

The paranoid bride and the tiger-striped priest

Because of the experimental and surrealistic nature of these poems, it is crucial to the reader's understanding that the two main characters be explicitly identified. They are: The Tiger-Striped Priest, commonly referred to as Ace. Ace is a muscular, earthy twenty-five pound tomcat. A cat-of-the-world, he has orange and white stripes and thick protruding jowls. His white whiskers spring upon the matter at hand with all the delicacy of a Sherman tank. The Paranoid Bride, sometimes presented as the narrator of the poems. The bride is a sliver of night rain. She is a magnetic recluse who pretends not to notice that people stare at her eyes. Her eyes are deep-sea dark and glimmer with the illumination of strange sea creatures that never rise to the surface. Both the Paranoid Bride and the Tiger-Striped Priest are a reflection of two different but interlocking forms of knowledge. The bride is representative of lunar knowledge, the knowledge of the subconscious mind. Ace is representative of solar knowledge, the knowledge of the conscious mind

An investigation of cross-situational consistency in the behavior of compulsive and histrionic personality disorders : an analogue study

Despite the relative lack of empirical data about personality disorders, the most commonly accepted definitions of them (e.g., DSM-III-R; Millon, 1981) incorporate assumptions of the relative temporal stability and cross-situational consistency of behavior. The present study examined the degree of behavioral consistency across specific types of experimental situations in persons classified as histrionic or compulsive personality disorder analogues. Different predictions regarding the degree to which subjects in this study would show behavioral consistency were made from the personologist, situationist, and interactionist models of human behavior

A comparison of the heroism of Antigone in the plays of Sophocles, Jean Cocteau, and Jean Anouilh

The Antigone of Sophocles has attracted French dramatists for centuries. From the Renaissance to the present, the translations and adaptations of this play have reflected many of the technical and theoretical changes in French drama. Two outstanding twentieth century playwrights, Jean Cocteau and Jean Anouilh, have borrowed Sophocles' plot for their plays. The purpose of this study is (l) to analyze the heroic nature of Antigone in the plays of Sophocles, Cocteau, and Anouilh, with special emphasis upon the motives underlying her heroic deed; (g) to compare Sophocles' heroine with that of the two French dramatists; (3) to investigate the reasons for the selection of Sophocles' play by Cocteau and Anouilh; and (4) to present the changes which Cocteau and Anouilh have made in their adaptations of Sophocles' tragedy

Poems

The world hangs upside down, her eyes forget to set it right. Time loops a hangman's knot; The window frames abstractions grossly set On canvas sky; dark grotesque shadows spot The floor like blood. Green capsule by her bed Requires its hour taking. Footsteps pass Outside the door; she listens till the lead Sounds disappear, while poising water glass At fevered lips. Soon rumpled head droops down On open book; the unread letters crawl From off the page, climb down her clinging gown, Stand mocking the prisoner from every wall. But pampered back to well, the girl must face, Though right side up, the larger prison case

Pausing under a glass dome

This novella illustrates the paradox between motive and appearance--the protagonist's inner life merges again and again into the texture of life in her observed world. Finally, what happens to her happens because she is the way she is