66 research outputs found
Unilateral versus bilateral thyroarytenoid Botulinum toxin injections in adductor spasmodic dysphonia: a prospective study
OBJECTIVES: In this preliminary prospective study, we compared unilateral and bilateral thyroarytenoid muscle injections of Botulinum toxin (Dysport) in 31 patients with adductor spasmodic dysphonia, who had undergone more than 5 consecutive Dysport injections (either unilateral or bilateral) and had completed 5 concomitant self-rated efficacy and complication scores questionnaires related to the previous injections. We also developed a Neurophysiological Scoring (NPS) system which has utility in the treatment administration. METHOD AND MATERIALS: Data were gathered prospectively on voice improvement (self-rated 6 point scale), length of response and duration of complications (breathiness, cough, dysphagia and total voice loss). Injections were performed under electromyography (EMG) guidance. NPS scale was used to describe the EMG response. Dose and unilateral/bilateral injections were determined by clinical judgment based on previous response. Time intervals between injections were patient driven. RESULTS: Low dose unilateral Dysport injection was associated with no significant difference in the patient's outcome in terms of duration of action, voice score (VS) and complication rate when compared to bilateral injections. Unilateral injections were not associated with any post treatment total voice loss unlike the bilateral injections. CONCLUSION: Unilateral low dose Dysport injections are recommended in the treatment of adductor spasmodic dysphonia
PHOTO-CIDNP STUDIES OF THE INFLUENCE OF LIGAND-BINDING ON THE SURFACE ACCESSIBILITY OF AROMATIC RESIDUES IN DIHYDROFOLATE-REDUCTASE
PHOTO-CIDNP STUDIES OF THE INFLUENCE OF LIGAND-BINDING ON THE SURFACE ACCESSIBILITY OF AROMATIC RESIDUES IN DIHYDROFOLATE-REDUCTASE
Thrombin inhibition by tripeptide aldehydes derived from D-Phe-Pro-Arg-H by replacing Arg with neutral residues
PHOTO-CIDNP STUDIES OF THE INFLUENCE OF LIGAND-BINDING ON THE SURFACE ACCESSIBILITY OF AROMATIC RESIDUES IN DIHYDROFOLATE-REDUCTASE
Balloon catheter injury to rabbit carotid artery. II. Selective increase in reactivity to some vasoconstrictor drugs.
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