ランダム化比較試験によるエドキサバン投与下におけるTKA後DVT発生に対するフットポンプの有効性

長崎大学学位論文 [学位記番号]博（医歯薬）甲第986号 [学位授与年月日]平成29年9月20

Relatório de estágio em farmácia comunitária

Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr

Photocatalytic bactericidal action of fluorescent light in a titanium dioxide particle mixture: an in vitro study.

Traditional titanium dioxide (TiO(2)) has photocatalytic bactericidal properties only under ultraviolet (UV) irradiation, which restricts its use in clinical treatment regimens. In this study, we evaluated the photocatalytic bactericidal effects of an aqueous system of TiO(2) particles irradiated by fluorescent light (FL) on Staphylococcus aureus. A TiO(2) particle mixture containing 19 ppm (0.019 mg/mL) of TiO(2) was prepared. A bacterial solution of 1 x 10(5) CFU/mL was added one drop at a time to the TiO(2) mixture. The resulting product was then irradiated with FL. The bacterial survival rate decreased steadily in the TiO(2) mixture group, reaching 76.7% after 30 min of FL irradiation and 10.9% after 60 min. After 60 to 180 min, the bacterial survival ratio of the TiO(2) mixture group was significantly lower than that of the control group (P < 0.05). The present study indicates that treating the surfaces of surgical devices and the surgical field with a TiO(2) particle mixture can create a nearly sterile environment that can be maintained throughout surgery, even at low luminous intensities

The Bactericidal Efficacy of a Photocatalytic TiO2 Particle Mixture with Oxidizer against Staphylococcus aureus

By proving the bactericidal effects of a low-concentration titanium dioxide (TiO2) particle mixture against Staphylococcus aureus, we hope to ultimately apply a mixture of this type as part of a clinical treatment regimen. A bacterial suspension of S. aureus 1×105 CFU/ml was added dropwise to a TiO2 particle mixture (19 ppm TiO2) and irradiated by ultraviolet (UV) light. The colony-forming units were counted and the bacterial survival rate was calculated. In the control sample, the bacterial survival rate was 83.3% even after 120 min. In the TiO2 mixture + UV sample, the bacteria count dropped sharply, reaching 17.3% of the baseline value at 30 min and 0.4% at 60 min. TiO2 particles dispersed in water mixtures are known to elicit highly efficient UV absorption and greater bonding to bacteria. A reaction of the TiO2 with another oxidizer altered the aqueous pH and accelerated the photocatalytic chemical reaction. The TiO2 particle mixture showed high antibacterial action against S. aureus even at a low concentration

Photocatalytic TiO2 particles confer superior antibacterial effects in a nutrition-rich environment: an in vitro study

Titanium dioxide (TiO2) is known to confer photocatalytic bactericidal effects under ultraviolet (UV) irradiation. Few reports are available, however, on the clinical applications of TiO2 particle mixtures. Our objective in the present research was to evaluate the in vitro bactericidal effects of a TiO2 particle mixture in a nutrition-rich biological environment. A bacterial suspension of Staph-ylococcus aureus and epidermidis 3 × 103CFU/mL was added to a TiO2 particle mixture (0.038 mg/mL) containing mainly sodium percarbonate and citric acid. To simulate a biological environment, 40 μL of 10% bovine serum albumin was added and the culture temperature was maintained at 37°C. The resulting product was irradiated by UV light and the bacterial survival rate was calculated for each time of UV irradiation. In the control sample treated with distilled water + UV, the bacteria survived at a high rate even after 180 min. In the TiO2 mixture+ UV sample, meanwhile, the bacterial survival rate dropped to 43.8% and 6.0% of the baseline values in S. aureus and S. epidermidis, respectively, after 60 min of UV irradiation. The photocatalytic antibacterial action of the TiO2 particle mixture was high even in a protein-rich biological environment