25 research outputs found
Damagnetization cooling of a gas
We demonstrate demagnetization cooling of a gas of ultracold Cr atoms.
Demagnetization is driven by inelastic dipolar collisions which couple the
motional degrees of freedom to the spin degree. By that kinetic energy is
converted into magnetic work with a consequent temperature reduction of the
gas. Optical pumping is used to magnetize the system and drive continuous
demagnetization cooling. Applying this technique, we can increase the phase
space density of our sample by one order of magnitude, with nearly no atom
loss. This method can be in principle extended to every dipolar system and
could be used to achieve quantum degeneracy via optical means.Comment: 10 pages, 5 figure
Influence of ground predators and water levels on Lapwing Vanellus vanellus breeding success in two continental wetlands
Effects of different size fractions of municipal solid waste compost on growth of Lolium perenne L.
Femoral tunnel widening is similar between anteromedial portal and transtibial techniques following single-bundle anterior cruciate ligament reconstruction: a systematic review and meta-analysis
What Do Users of Generic Medicines Think of Them? A Systematic Review of Consumers’ and Patients’ Perceptions of, and Experiences with, Generic Medicines
Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study
Geochemistry of canga (ferricrete) and evolution of the weathering profile developed on itabirite and iron ore in the Quadrilátero Ferrífero, Minas Gerais, Brazil
Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus
Based on in vitro synergy studies, the addition of nafcillin to daptomycin was used to treat refractory methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Daptomycin is a de facto cationic antimicrobial peptide in vivo, with antistaphylococcal mechanisms reminiscent of innate host defense peptides (HDPs). In this study, the effects of nafcillin on HDP activity against MRSA were examined in vitro and in vivo. Exposures to β-lactam antimicrobials in general, and nafcillin in particular, significantly increased killing of S. aureus by selected HDPs from, keratinocytes, neutrophils and platelets. This finding correlated with enhanced killing of MRSA by whole blood, neutrophils and keratinocytes after growth in nafcillin. Finally, nafcillin pretreatment ex vivo reduced MRSA virulence in a murine subcutaneous infection model. Despite the lack of direct activity against MRSA, these studies show potent, consistent, and generalized nafcillin-mediated ‘sensitization’ to increased killing of MRSA by various components of the innate host response. The use of nafcillin as adjunctive therapy in MRSA bacteremia merits further study and should be considered in cases refractory to standard therapy