87 research outputs found
Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
- Author
- AI Bush
- AI Bush
- Alberto Granzotto
- AR Ladiwala
- AS Darvesh
- C Behl
- C Hureau
- C Riviere
- C Rivière
- CA de la Lastra
- CJ Lin
- CS Atwood
- D Drago
- D Drago
- D Pratico
- DG Smith
- DJ Boocock
- DM Walsh
- F Chiti
- GM Shankar
- HP Lee
- HW Querfurth
- I Shcherbatykh
- IM Kapetanovic
- J Gruber
- J Kim
- J Wang
- JA Duce
- JG Wood
- JK Andersen
- K Hensley
- K Ono
- KN Dahlgren
- KT Howitz
- L Fremont
- L Wan
- M Manczak
- M Stoltenberg
- M Suwalsky
- MA Lovell
- MR Nilsson
- MS Shearman
- NG Milton
- P Zatta
- Paolo Zatta
- Peter Csermely
- PW Mantyh
- RG Alscher
- S Bolognin
- S Gandy
- S Varadarajan
- S Yumoto
- SA Hudson
- SS Karuppagounder
- SV Verstraeten
- TE Golde
- V Kumar
- V Vingtdeux
- WF Xue
- X Huang
- X Huang
- Y Miller
- Publication venue
- Public Library of Science
- Publication date
- 27/06/2011
- Field of study
It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties
Functional response to cholinesterase inhibitor therapy in a naturalistic Alzheimer’s disease cohort
- Author
- A Atri
- A Frances
- A Santoro
- AK Wallin
- AK Wallin
- AS Rigaud
- B Reisberg
- B Winblad
- C Franchi
- C Wattmo
- C Wattmo
- C Wattmo
- Carina Wattmo
- CW Ritchie
- D Galasko
- D Galasko
- D Galasko
- DG Wilkinson
- E Mossello
- EM Inelmen
- G Alva
- G McKhann
- GK Wilcock
- HT Hatoum
- J Hill
- J Razani
- JA Mortimer
- JL Molinuevo
- Lennart Minthon
- M Evans
- M Rosler
- MF Folstein
- MP Lawton
- MR Farlow
- MR Farlow
- O Almkvist
- P Barberger-Gateau
- P Behl
- PA Boyle
- R Bullock
- R Van Der Putt
- RC Green
- RC Mohs
- S Gauthier
- SH MacGowan
- TB Atchison
- VN Pavlik
- WG Rosen
- Åsa K Wallin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
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- AA Farooqui
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
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- AI Bush
- AI Bush
- AI Bush
- AI Bush
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- B Chakravarti
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- VR Gordeuk
- VR Gordeuk
- VR Taqueti
- W Aerbajinai
- W Breuer
- W Craelius
- W Davis Jr
- W Dichtl
- W Dröge
- W Dröge
- W Hu
- W Kalt
- W Kong
- W Li
- W Ma
- W Mair
- W Makropoulos
- W Ondo
- W Tungwiwat
- WA Cass
- WB Dunn
- WB Ershler
- WB Kannel
- WI Leong
- WJ Jo
- WK Adkins
- WL Neeley
- WM Campana
- WR Farwell
- WR Markesbery
- WR Markesbery
- WS Jeong
- WS Yang
- WW Huber
- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy
- Author
- A Brunet
- A Ferdous
- A Kuma
- A Sengupta
- A Sengupta
- A Takada
- AF Amos
- AS Vriese De
- B Cai
- B Ponugoti
- B Wang
- BM Balletshofer
- CM Rosa
- CW Younce
- CX Fang
- D Aronson
- D Constantin-Teodosiu
- D Lam
- D Schmoll
- D Su
- D Weigel
- D Weigel
- Dan Yan
- DD Belke
- DN Gross
- DP Relling
- DS Bell
- EL Greer
- EL Greer
- G Tzivion
- GA Nichols
- GJ Kops
- GJ Kops
- H Daitoku
- H Daitoku
- H Huang
- H Li
- Haobo Li
- HJ Evans-Anderson
- HY Lee
- I Lekli
- IG Poornima
- J Altomonte
- J Buteau
- J Dabek
- J He
- J Nakae
- J Nakae
- J Nakae
- J Sakamaki
- J Seoane
- J Tanaka
- J Wang
- JA Siegenthaler
- JB Morris
- JFC Guimaraes
- JJ Kim
- JM Park
- JS Dobrin
- K Khavandi
- K Ma
- K Maiese
- K Maiese
- K Nishida
- K Yamagata
- KE Vos van der
- KW Yip
- L Ozcan
- L Pereira
- L Qiang
- M Alikhani
- M Alikhani
- M Kuo
- M Majer
- M Potente
- M Seddon
- M Stahl
- MA Essers
- MC Hu
- MC Motta
- Michael G. Irwin
- MJ Berridge
- MR Abid
- MT Johnstone
- N Hariharan
- P Puigserver
- P Puthanveetil
- P Puthanveetil
- P Storz
- PK Battiprolu
- Qingquan Lian
- Qiqi Zhu
- R Kumarswamy
- Ramoji Kosuru
- Ren-shan Ge
- RH Medema
- RH Medema
- RK Hall
- RR Alcendor
- RR Gomis
- RR Gomis
- S Boudina
- S Hannenhalli
- S Hannenhalli
- S Nemoto
- S Qu
- S Sharma
- SA Hayat
- SC Martinez
- SM Ronnebaum
- SR Datta
- T Furuyama
- T Hosaka
- T Kitamura
- T Kitamura
- T Obsil
- T Obsil
- TH Marwick
- U Harjes
- U Hink
- V Cifarelli
- Vidya Kandula
- W Fan
- W Guo
- WB Kannel
- WB Kannel
- WJ Bakker
- WM Shaw
- X Li
- Y Behl
- Y Hattori
- Y Ito
- Y Qi
- Y Zhao
- YG Ni
- YG Ni
- YI Kitamura
- YM Song
- YY Wang
- Z Cheng
- Z Liu
- Zhengyuan Xia
- ZZ Chong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis
- Author
- A Aleman
- A Alonso
- A Britton
- A Cherubini
- A Cherubini
- A Garcia
- A Karp
- A Lobo
- A Marengoni
- A Nordberg
- A Ogunniyi
- A Ott
- A Ott
- A Ott
- A Ott
- AB Ford
- AB Mendelsohn
- AC Nooyens
- AF Jorm
- AF van Raamt
- AH Ford
- AH Ford
- AJ Schuit
- AK Campbell
- AL Gross
- Alan B Zonderman
- Alison Teel
- Alyssa A Gamaldo
- AP Smith
- AS Buchman
- B Rodgers
- B Schmand
- B Schmand
- BE Alvarado
- BM van Gelder
- BM van Gelder
- C Behl
- C Crecelius
- C Dufouil
- C Dufouil
- C Dullemeijer
- C Qiu
- C Reitz
- C Reitz
- C Reitz
- C Samieri
- C Samieri
- C Santos
- CB Begg
- CB Wright
- CC Wang
- CE Teunissen
- CG Lyketsos
- CJ Maxwell
- CM Callahan
- CQ Huang
- CW Cotman
- D Carmelli
- D De Ronchi
- D Galasko
- D Gavrila
- D Juan
- D Krahn
- D Laurin
- D Laurin
- D Zekry
- DA Evans
- DA Evans
- DB Petitti
- DE Barnes
- DE Zylberstein
- DF Zhou
- DJ Galanis
- DJ Moritz
- DM Kado
- DR Taaffe
- E Albanese
- E Castro-Costa
- E Herrera Jr
- E Kesse-Guyot
- E Kroger
- E Nurk
- E Ronnemaa
- EB Larson
- EE Devore
- EE Devore
- ES Paykel
- F Gomez-Pinilla
- F Grodstein
- F Landi
- F Lin
- F Pignatti
- F Zanjani
- G Li
- G McKhann
- G McNeill
- G Ravaglia
- G Ravaglia
- G Ravaglia
- G Ravaglia
- G Xu
- G Zuccala
- GA Broe
- GC Roman
- GE Bond
- GE Bond
- GE Bond
- GG Fillenbaum
- GM McKhann
- H Christensen
- H Christensen
- H Refsum
- H Zhou
- HC Hendrie
- HC Liu
- Hind A Beydoun
- HJ Wengreen
- I Leroi
- IG McKeith
- II Kruman
- J Ankri
- J Corley
- J Corley
- J de Champlain
- J Kim
- J Selhub
- J Verghese
- J Weuve
- JA Cervilla
- JA Luchsinger
- JA Luchsinger
- JE Dunn
- JE James
- JH Schafer
- JL Cobb
- JM Kim
- JM Kim
- JM Peacock
- JR Cerhan
- JS Vidal
- JW Jama
- JW Miller
- K Battig
- K Koivisto
- K Ritchie
- K Yaffe
- K Yaffe
- KA Cagney
- KH Masaki
- KK Chan
- KL Tucker
- KS Bjerve
- L Arab
- L Arab
- L Feng
- L Feng
- L Feng
- L Kilander
- L Letenneur
- L Letenneur
- L Letenneur
- L Li
- L White
- L Zhang
- LB Zahodne
- LE Herbert
- LE Middleton
- LJ Podewils
- M Andreassi
- M Chang
- M Egger
- M Egger
- M Egger
- M Fotuhi
- M Gallucci
- M Ganguli
- M Grundman
- M Haag
- M Hildebrandt
- M Johnson-Kozlow
- M Richards
- M Richards
- M Rusanen
- M Rusanen
- M Scazufca
- MA Beydoun
- MA Beydoun
- May A Beydoun
- MC de Wilde
- MC Morris
- MC Morris
- MC Morris
- MC Morris
- MC Morris
- MC Morris
- MC Norton
- MC Reid
- MC Stewart
- ME Farmer
- ME Lytle
- MF Elias
- MF Elias
- MF Elias
- MF Muldoon
- MF Shadlen
- MH Eskelinen
- MH Eskelinen
- MI Ramos
- MJ Dealberto
- MJ Engelhart
- MJ Engelhart
- MJ Engelhart
- MJ Jarvis
- MJ Stampfer
- MM Fichter
- MN Haan
- MN Vercambre
- MP van Boxtel
- MS Albert
- MT Sturman
- MY Zhang
- N Collins
- N Scarmeas
- ND Prins
- NT Akbaraly
- O Aevarsson
- O van de Rest
- P Barberger-Gateau
- P Quadri
- P Verhaeghen
- PB Gorelick
- PB Gorelick
- PC Elwood
- PE Wainwright
- PK Elias
- PP Zandi
- PS Mathuranath
- PS Sachdev
- Q Gao
- R Clarke
- R Doll
- R Perneczky
- R Peters
- R Schmidt
- RA Whitmer
- RB Parsons
- RD Abbott
- RE Dustman
- RF Gillum
- RG Wight
- RL Rogers
- RP Gelber
- RS Wilson
- RS Wilson
- RT Lin
- S Ariogul
- S Bleich
- S Cerolini
- S Gonzalez
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kalmijn
- S Kuriyama
- S Lee
- S Lee
- S Mejia-Arango
- S Redeen
- S Rovio
- S Sabia
- S Sabia
- S Sabia
- S Seshadri
- SA van Hooren
- SC Ho
- SJ Duthie
- SL Au Yeung
- SL Edelstein
- SL Gray
- SL Gray
- SL Tyas
- SP Mooijaart
- STATA
- T Anttila
- T Bottiglieri
- T den Heijer
- T Etgen
- T Hanninen
- T Ngandu
- T Psaltopoulou
- TA Hamid
- TE Seeman
- The Lund and Manchester Groups
- TM Scott
- TM Thomson
- TN van den Kommer
- TP Ng
- V Solfrizzi
- V Solfrizzi
- VC Hachinski
- VM Dotson
- VS Laitala
- W Freidl
- W Riedel
- WR Markesbery
- WT Chen
- WW Spirduso
- Y Christen
- Youfa Wang
- ZX Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Economics of Personalized Medicine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
Distributed control of a swarm of buildings connected to a smart grid
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 03/11/2014
- Field of study
- …