41 research outputs found
Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection
Pregroup Analysis of Persian Sentences
In muscle tissue the protein caveolin-3 forms caveolae – flask-shaped invaginations localized on the cytoplasmic surface of the sarcolemmal membrane. Caveolae have a key role in the maintenance of plasma membrane integrity and in the processes of vesicular trafficking and signal transduction. Mutations in the caveolin-3 gene lead to skeletal muscle pathology through multiple pathogenetic mechanisms. Indeed, caveolin-3 deficiency is associated to sarcolemmal membrane alterations, disorganization of skeletal muscle T-tubule network and disruption of distinct cell-signaling pathways. To date, there have been 30 caveolin-3 mutations identified in the human population. Caveolin-3 defects lead to four distinct skeletal muscle disease phenotypes: limb girdle muscular dystrophy, rippling muscle disease, distal myopathy, and hyperCKemia. In addition, one caveolin-3 mutant has been described in a case of hypertrophic cardiomyopathy. Many patients show an overlap of these symptoms and the same mutation can be linked to different clinical phenotypes. This variability can be related to additional genetic or environmental factors. This review will address caveolin-3 biological functions in muscle cells and will describe the muscle and heart disease phenotypes associated with caveolin-3 mutations
Marshal Ney before and after execution; with numerous illustrations;
Supplement: Extracts from J. A. Weston's "Historic doubts as to the execution of Marshal Ney". Part II. "Was Marshal Ney executed." Chapter I."Documentary proofs ... of Marshal Ney's escape from execution and his exile in America": p. [229]-404.Bibliography included in preface.Mode of access: Internet
Index ... Eldorado : or California, as seen by a pioneer, 1850- 1900 /
SEAR Project 2-F2-132 (3-F2-197).Mimeographed.Mode of access: Internet
CARNITINE PALMITOYL TRANSFERASE-I INHIBITION IS NOT ASSOCIATED WITH CARDIAC HYPERTROPHY IN RATS FED A HIGH-FAT DIET
A falta de informação sobre os Organismos Geneticamente Modificados no Brasil
O presente artigo apresenta uma revisão sobre a rotulagem de produtos que apresentem em sua composição Organismos Geneticamente Modificados (OGM), também denominados de transgênicos. São abordadas as convenções, as leis e as normas referentes a esses produtos dispostos no mercado, a adequação dos mesmos às normas vigentes e sua aceitação pela sociedade. Dispõe também sobre a importância do princípio da precaução na avaliação da aplicação de novas tecnologias ou de tecnologias das quais não se conhece ou existam conhecimentos científicos relevantes quanto aos seus potenciais riscos ao meio ambiente, à saúde humana e à sociedade.This article presents a review about the labeling of products that have Genetically Modified Organisms (GMO), also called transgenic elements in their composition. It addresses the conventions, laws and regulations relating to such products currently governing the market, the adequacy of these existing standards and their acceptance by society. It also examines the importance of the cautionary principle when assessing the application of new technologies or technologies where little is known or where there is no relevant scientific knowledge about the potential risks to the environment, human health and society
Biomechanical evaluation of an arthroscopic transosseous repair as a revision option for failed rotator cuff surgery
Drying Technology: Trends and Applications in Postharvest Processing
10.1007/s11947-010-0353-1Food and Bioprocess Technology36843-85
