Severe Autoimmune Diseases

This section deals with ovarian protection in non-malignant, rheumatic or other autoimmune diseases. Since these diseases are disproportionately common in young women, knowledge of the negative effects of immunosuppressive agents on the ovarian reserve, as well as the possibilities and limitations of ovarian protective measures, even in this particular patient population, is essential. According to current data, we should offer patients at increased risk of POI treatment with GnRH analogues when using cyclophosphamide. In addition, the use of ovarian cryopreservation (short time frame, sufficiently high ovarian reserve) should be generously considered. Ovarian stimulation therapy is only advisable in rare cases, as many patients are at risk of exacerbation of the underlying disease