Phytochemical Screening and Antioxidant Activity of Selekop (Lepisanthes Amoena) Fruit

Selekop (Lepisanthes amoena (Hassk.) Leenh.) plant leaves are used by the Dayak tribe of East Kalimantan as traditional cosmetics. Selekop fruit is also edible, but not well known. This study was conducted to obtain the phytochemical content and antioxidant assay in flesh, seed and pericarp extracts from the fruit of Selekop. Phytochemical analysis was conducted on ethanol extract for identification of flavonoid, alkaloid, tannin, saponin, triterpenoid and steroid. The antioxidant activity was done by DPPH assay with ascorbic acid as positive control. The flesh contained flavonoid, saponin, and tannin; the seed contained flavonoid, alkaloid, saponin, triterpenoid, and tannin; and the pericarp contained flavonoid, alkaloid, saponin, triterpenoid, and tannin. Analysis of antioxidant activity revealed the following Inhibitory Concentration (IC50 values): 122.51 ppm of flesh, 63.30 ppm of seed, 53.21 ppm of pericarp and 3.06 ppm of ascorbic acid. Based on these results, the ethanol extract of the seed and the flesh had a phytochemical content and antioxidant activity which was better than the flesh extract from Selekop fuit

Evaluation of Isolated Compounds From Wood of Artocarpus Heterophyllus as a Cosmetic Agent

In our efforts to find new whitening agent materials, we focused on wood of Artocarpus heterophyllus which is anti melanogenesis. By activity-guided fractionation of A. heterophyllus wood extract, norartocarpetin and artocarpesin were isolated which inhibited both mushroom tyrosinase activity and melanin formation in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin that can be used for cosmetic (whitening agent)

Artocarpin, a Promising Compound as Whitening Agent and Anti-skin Cancer

In our search for natural products from wood on cosmetics and drugs purposes and on the basis of melanin biosynthesis assay guided fractionation, artocarpin was isolated from wood of Nangka (Artocarpus heterophyllus). To evaluate the potency as a whitening agent of artocarpin and its anti-skin cancer (cytotoxicity effect), the MTT assay was used to evaluate its cytotoxicity on cells and melanin biosynthesis assays was performed to determine its whitening agents potency. The evaluation of cytotoxicity on B16 melanoma cells of Artocarpin resulted the IC50 was 10.3 µM and melanin biosynthesis assay with IC50 6.7 µM with out cytotoxicity. Based on the results, suggested that artocarpin have a potent to be developed as whitening agent and skin cancer drug