Scientific assessment of the use of sugars as cigarette tobacco ingredients: A review of published and other publicly available studies

Sugars, such as sucrose or invert sugar, have been used as tobacco ingredients in American-blend cigarettes to replenish the sugars lost during curing of the Burley component of the blended tobacco in order to maintain a balanced flavor. Chemical-analytical studies of the mainstream smoke of research cigarettes with various sugar application levels revealed that most of the smoke constituents determined did not show any sugar-related changes in yields (per mg nicotine), while ten constituents were found to either increase (formaldehyde, acrolein, 2-butanone, isoprene, benzene, toluene, benzo[k]fluoranthene) or decrease (4-aminobiphenyl, N-nitrosodimethylamine, N-nitrosonornicotine) in a statistically significant manner with increasing sugar application levels. Such constituent yields were modeled into constituent uptake distributions using simulations of nicotine uptake distributions generated on the basis of published nicotine biomonitoring data, which were multiplied by the constituent/nicotine ratios determined in the current analysis. These simulations revealed extensive overlaps for the constituent uptake distributions with and without sugar application. Moreover, the differences in smoke composition did not lead to relevant changes in the activity in in vitro or in vivo assays. The potential impact of using sugars as tobacco ingredients was further assessed in an indirect manner by comparing published data from markets with predominantly American-blend or Virginia-type (no added sugars) cigarettes. No relevant difference was found between these markets for smoking prevalence, intensity, some markers of dependence, nicotine uptake, or mortality from smoking-related lung cancer and chronic obstructive pulmonary disease. In conclusion, thorough examination of the data available suggests that the use of sugars as ingredients in cigarette tobacco does not increase the inherent risk and harm of cigarette smoking

Influence of upper ocean on Indian summer monsoon rainfall: studies by observation and NCEP climate forecast system(CFSv2)

This study explores the role played by ocean processes in influencing Indian summer monsoon rainfall (ISMR) and compares the observed findings with National Centers for Environmental Prediction (NCEP)-coupled model Climate Forecast System, version 2 (CFSv2). The excess and deficit ISMR clearly brings out the distinct signatures in sea surface height (SSH) anomaly, thermocline and mixed layer depth over north Indian Ocean. CFSv2 is successful in simulating SSH anomalies, especially over Arabian Sea and Bay of Bengal region. CFSv2 captures observed findings of SSH anomalies during flood and drought (e.g., Rossby wave propagation which reaches western Bay of Bengal (BoB) during flood years, Rossby wave propagation which did not reach western BoB during drought). It highlights the ability of CFSv2 to simulate the basic ocean processes which governs the SSH variability. These differences are basically generated by upwelling and downwelling caused by the equatorial and coastal Kelvin and Rossby waves, thereby causing difference in SSH anomaly and thermocline, and subsequently modifying the convection centers, which dictates precipitation over the Indian subcontinent region. Since the observed SSH anomaly and thermal structure show distinct characteristic features with respect to strong and weak ISMR variability, the assimilation of real ocean data in terms of satellite products (like SSHA from AVISO/SARAL) bestow great promise for the future improvement