2,574 research outputs found
Anomalous specific heat jump in the heavy fermion superconductor CeCoIn
We study the anomalously large specific heat jump and its systematic change
with pressure in CeCoIn superconductor. Starting with the general free
energy functional of the superconductor for a coupled electron boson system, we
derived the analytic result of the specific heat jump of the strong coupling
superconductivity occurring in the coupled electron boson system. Then using
the two component spin-fermion model we calculate the specific heat coefficient
both for the normal and superconducting states and show a good
agreement with the experiment of CeCoIn. Our result also clearly
demonstrated that the specific heat coefficient of a coupled electron
boson system can be freely interpreted as a renormalization either of the
electronic or of the bosonic degrees of freedom.Comment: 5 pages, 2 figure
First-trimester or second-trimester screening, or both, for Down's syndrome
BACKGROUND: It is uncertain how best to screen pregnant women for the presence of fetal Down's syndrome: to perform first-trimester screening, to perform second-trimester screening, or to use strategies incorporating measurements in both trimesters.METHODS: Women with singleton pregnancies underwent first-trimester combined screening (measurement of nuchal translucency, pregnancy-associated plasma protein A [PAPP-A], and the free beta subunit of human chorionic gonadotropin at 10 weeks 3 days through 13 weeks 6 days of gestation) and second-trimester quadruple screening (measurement of alpha-fetoprotein, total human chorionic gonadotropin, unconjugated estriol, and inhibin A at 15 through 18 weeks of gestation). We compared the results of stepwise sequential screening (risk results provided after each test), fully integrated screening (single risk result provided), and serum integrated screening (identical to fully integrated screening, but without nuchal translucency).RESULTS: First-trimester screening was performed in 38,167 patients; 117 had a fetus with Down's syndrome. At a 5 percent false positive rate, the rates of detection of Down's syndrome were as follows: with first-trimester combined screening, 87 percent, 85 percent, and 82 percent for measurements performed at 11, 12, and 13 weeks, respectively; with second-trimester quadruple screening, 81 percent; with stepwise sequential screening, 95 percent; with serum integrated screening, 88 percent; and with fully integrated screening with first-trimester measurements performed at 11 weeks, 96 percent. Paired comparisons found significant differences between the tests, except for the comparison between serum integrated screening and combined screening.CONCLUSIONS: First-trimester combined screening at 11 weeks of gestation is better than second-trimester quadruple screening but at 13 weeks has results similar to second-trimester quadruple screening. Both stepwise sequential screening and fully integrated screening have high rates of detection of Down's syndrome, with low false positive rates
Online Multi-Coloring with Advice
We consider the problem of online graph multi-coloring with advice.
Multi-coloring is often used to model frequency allocation in cellular
networks. We give several nearly tight upper and lower bounds for the most
standard topologies of cellular networks, paths and hexagonal graphs. For the
path, negative results trivially carry over to bipartite graphs, and our
positive results are also valid for bipartite graphs. The advice given
represents information that is likely to be available, studying for instance
the data from earlier similar periods of time.Comment: IMADA-preprint-c
FCNC Processes from D-brane Instantons
Low string scale models might be tested at the LHC directly by their Regge
resonances. For such models it is important to investigate the constraints of
Standard Model precision measurements on the string scale. It is shown that
highly suppressed FCNC processes like K0- bar K^0 oscillations or leptonic
decays of the D0-meson provide non-negligible lower bounds on both the
perturbatively and surprisingly also non-perturbatively induced string theory
couplings. We present both the D-brane instanton formalism to compute such
amplitudes and discuss various possible scenarios and their constraints on the
string scale for (softly broken) supersymmetric intersecting D-brane models.Comment: 28 pages, 13 figures, reference added, 1 typo corrected, style file
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Challenges of Loss to Follow-up in Tuberculosis Research.
In studies evaluating methods for diagnosing tuberculosis (TB), follow-up to verify the presence or absence of active TB is crucial and high dropout rates may significantly affect the validity of the results. In a study assessing the diagnostic performance of the QuantiFERON®-TB Gold In-Tube test in TB suspect children in Tanzania, factors influencing patient adherence to attend follow-up examinations and reasons for not attending were examined. In 160 children who attended and 102 children who did not attend scheduled 2-month follow-up baseline health characteristics, demographic data and risk factors for not attending follow-up were determined. Qualitative interviews were used to understand patient and caretakers reasons for not returning for scheduled follow-up. Being treated for active tb in the dots program (OR: 4.14; 95% CI:1.99-8.62;p-value<0.001) and receiving money for the bus fare (OR:129; 95% CI 16->100;P-value<0.001) were positive predictors for attending follow-up at 2 months, and 21/85(25%) of children not attending scheduled follow-up had died. Interviews revealed that limited financial resources, i.e. lack of money for transportation and poor communication, were related to non-adherence. Patients lost to follow-up is a potential problem for TB research. Receiving money for transportation to the hospital and communication is crucial for adherence to follow-up conducted at a study facility. Strategies to ensure follow-up should be part of any study protocol
Loop Quantum Gravity and the The Planck Regime of Cosmology
The very early universe provides the best arena we currently have to test
quantum gravity theories. The success of the inflationary paradigm in
accounting for the observed inhomogeneities in the cosmic microwave background
already illustrates this point to a certain extent because the paradigm is
based on quantum field theory on the curved cosmological space-times. However,
this analysis excludes the Planck era because the background space-time
satisfies Einstein's equations all the way back to the big bang singularity.
Using techniques from loop quantum gravity, the paradigm has now been extended
to a self-consistent theory from the Planck regime to the onset of inflation,
covering some 11 orders of magnitude in curvature. In addition, for a narrow
window of initial conditions, there are departures from the standard paradigm,
with novel effects, such as a modification of the consistency relation
involving the scalar and tensor power spectra and a new source for
non-Gaussianities. Thus, the genesis of the large scale structure of the
universe can be traced back to quantum gravity fluctuations \emph{in the Planck
regime}. This report provides a bird's eye view of these developments for the
general relativity community.Comment: 23 pages, 4 figures. Plenary talk at the Conference: Relativity and
Gravitation: 100 Years after Einstein in Prague. To appear in the Proceedings
to be published by Edition Open Access. Summarizes results that appeared in
journal articles [2-13
A Kernel to Exploit Informative Missingness in Multivariate Time Series from EHRs
A large fraction of the electronic health records (EHRs) consists of clinical
measurements collected over time, such as lab tests and vital signs, which
provide important information about a patient's health status. These sequences
of clinical measurements are naturally represented as time series,
characterized by multiple variables and large amounts of missing data, which
complicate the analysis. In this work, we propose a novel kernel which is
capable of exploiting both the information from the observed values as well the
information hidden in the missing patterns in multivariate time series (MTS)
originating e.g. from EHRs. The kernel, called TCK, is designed using an
ensemble learning strategy in which the base models are novel mixed mode
Bayesian mixture models which can effectively exploit informative missingness
without having to resort to imputation methods. Moreover, the ensemble approach
ensures robustness to hyperparameters and therefore TCK is particularly
well suited if there is a lack of labels - a known challenge in medical
applications. Experiments on three real-world clinical datasets demonstrate the
effectiveness of the proposed kernel.Comment: 2020 International Workshop on Health Intelligence, AAAI-20. arXiv
admin note: text overlap with arXiv:1907.0525
The middle ear of the pink fairy armadillo Chlamyphorus truncatus (Xenarthra, Cingulata, Chlamyphoridae): comparison with armadillo relatives using computed tomography.
The pink fairy armadillo Chlamyphorus truncatus is the smallest extant armadillo and one of the least-known fossorial mammals. The aim of this study was to establish if its middle ear is specially adapted to the subterranean environment, through comparison with more epigeic relatives of the groups Euphractinae (Chaetophractus villosus, Chaetophractus vellerosus, Zaedyus pichiy) and Dasypodinae (Dasypus hybridus). We examined the middle ears using micro-computed tomography and subsequent three-dimensional reconstructions. D. hybridus has a relatively small middle ear cavity, an incomplete bulla and 'ancestral' ossicular morphology. The other species, including Chlamyphorus, have fully ossified bullae and middle ear ossicles, with a morphology between 'transitional' and 'freely mobile', but in all armadillos the malleus retains a long anterior process. Unusual features of armadillo ears include the lack of a pedicellate lenticular apophysis and the presence, in some species, of an element of Paaw within the stapedius muscle. In common with many subterranean mammals, Chlamyphorus has a relatively flattened malleo-incudal articulation and appears to lack a functional tensor tympani muscle. Its middle ear cavity is not unusually enlarged, and its middle ear ossicles seem less robust than those of the other armadillos studied. In comparison with the euphractines, there is no reason to believe that the middle ear of this species is specially adapted to the subterranean environment; some aspects may even be indicative of degeneration. The screaming hairy armadillo, Chaetophractus vellerosus, has the most voluminous middle ear in both relative and absolute terms. Its hypertrophied middle ear cavity likely represents an adaptation to low-frequency hearing in arid rather than subterranean conditions.Argentinian research grants: Secretaría General de Ciencia y Tecnología, UNS (Project PGI 24/B243); Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) through a PhD fellowship to APB; Subsecretaría de Relaciones Internacionales, UNS, through a grant to APB
X-ray Absorption and Reflection in Active Galactic Nuclei
X-ray spectroscopy offers an opportunity to study the complex mixture of
emitting and absorbing components in the circumnuclear regions of active
galactic nuclei, and to learn about the accretion process that fuels AGN and
the feedback of material to their host galaxies. We describe the spectral
signatures that may be studied and review the X-ray spectra and spectral
variability of active galaxies, concentrating on progress from recent Chandra,
XMM-Newton and Suzaku data for local type 1 AGN. We describe the evidence for
absorption covering a wide range of column densities, ionization and dynamics,
and discuss the growing evidence for partial-covering absorption from data at
energies > 10 keV. Such absorption can also explain the observed X-ray spectral
curvature and variability in AGN at lower energies and is likely an important
factor in shaping the observed properties of this class of source.
Consideration of self-consistent models for local AGN indicates that X-ray
spectra likely comprise a combination of absorption and reflection effects from
material originating within a few light days of the black hole as well as on
larger scales. It is likely that AGN X-ray spectra may be strongly affected by
the presence of disk-wind outflows that are expected in systems with high
accretion rates, and we describe models that attempt to predict the effects of
radiative transfer through such winds, and discuss the prospects for new data
to test and address these ideas.Comment: Accepted for publication in the Astronomy and Astrophysics Review. 58
pages, 9 figures. V2 has fixed an error in footnote
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