5 research outputs found
A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: design and methodology [ISRCTN78467674]
- Author
- A Bird
- A Chopdar
- AEC Bird
- AP Schachat
- B Halliwell
- B R Jr Hammond
- BS Hawkins
- C Delcourt
- CCW Klaver
- CCW Klaver
- CK Dorey
- DJ Jr Tate
- DS Friedman
- E Friedman
- E Friedman
- ER Gaillard
- Expert Group on Vitamins and Minerals
- F Khachik
- FG.et.al Holz
- Frank Eperjesi
- G Paolisso
- G Paolisso
- GJ Handelman
- GS Brindley
- H Bartlett
- HA Kahn
- HA Kahn
- Hannah Bartlett
- IM et.al Heiba
- J Ambati
- J Goldberg
- J Skrha
- JA.et.al Mares-Perlman
- JE Grunwald
- JE Grunwald
- JJ Arnold
- JJ Kanski
- JM Seddon
- JR Evans
- JT Landrum
- JT Landrum
- JT Pinto
- KJ Cruickshanks
- L Hyman
- LA Yannuzzi
- LC Nebeling
- LC Nebeling
- LG Hyman
- LM Jampol
- LM Rapp
- M Delmelle
- M MacKeben
- M Rozanowska
- ML Bierenbaum
- MOM Tso
- NB Tütüncü
- NG Bazan
- NM Bressler
- NM Bressler
- O Isler
- P Mitchell
- PA Southorn
- PS Bernstein
- R Klein
- R Klein
- RA
- RA Bone
- RC Rose
- RC Watzke
- RL Hawkins
- RP Murphy
- S Beatty
- S Beatty
- S Richer
- Tamakoshi
- The Age-Related Eye Disease Study Research Group
- TM Florence
- Ttjm Berendschot
- TW Goodwin
- United Nations
- V Rawes
- W Sickel
- W Smith
- W Smith
- W Smith
- WL Stone
- World Medical Association
- WT Jr Ham
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
BACKGROUND: Age-related macular disease is the leading cause of blind registration in the developed world. One aetiological hypothesis involves oxidation, and the intrinsic vulnerability of the retina to damage via this process. This has prompted interest in the role of antioxidants, particularly the carotenoids lutein and zeaxanthin, in the prevention and treatment of this eye disease. METHODS: The aim of this randomised controlled trial is to determine the effect of a nutritional supplement containing lutein, vitamins A, C and E, zinc, and copper on measures of visual function in people with and without age-related macular disease. Outcome measures are distance and near visual acuity, contrast sensitivity, colour vision, macular visual field, glare recovery, and fundus photography. Randomisation is achieved via a random number generator, and masking achieved by third party coding of the active and placebo containers. Data collection will take place at nine and 18 months, and statistical analysis will employ Student's t test. DISCUSSION: A paucity of treatment modalities for age-related macular disease has prompted research into the development of prevention strategies. A positive effect on normals may be indicative of a role of nutritional supplementation in preventing or delaying onset of the condition. An observed benefit in the age-related macular disease group may indicate a potential role of supplementation in prevention of progression, or even a degree reversal of the visual effects caused by this condition
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
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- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
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- W Breuer
- W Craelius
- W Davis Jr
- W Dichtl
- W Dröge
- W Dröge
- W Hu
- W Kalt
- W Kong
- W Li
- W Ma
- W Mair
- W Makropoulos
- W Ondo
- W Tungwiwat
- WA Cass
- WB Dunn
- WB Ershler
- WB Kannel
- WI Leong
- WJ Jo
- WK Adkins
- WL Neeley
- WM Campana
- WR Farwell
- WR Markesbery
- WR Markesbery
- WS Jeong
- WS Yang
- WW Huber
- WW Wong
- WY Ong
- X Chen
- X Chen
- X He
- X Huang
- X Huang
- X Huang
- X Li
- X Zhang
- X Zhu
- X Zhu
- XD Huang
- XJ Li
- XM Yuan
- XM Yuan
- XP Huang
- Y Almog
- Y Avramovich-Tirosh
- Y Bao
- Y Bdolah
- Y Chen
- Y Christen
- Y Curin
- Y Deugnier
- Y Deugnier
- Y Engin-Üstün
- Y Ge
- Y Gilgun-Sherki
- Y Haruna
- Y Honda
- Y Hua
- Y Ikeda
- Y Jiao
- Y Jung
- Y Ke
- Y Ke
- Y Kohgo
- Y Kohgo
- Y Levites
- Y Li
- Y Okatani
- Y Okatani
- Y Sai
- Y Sai
- Y Sun
- Y Takada
- Y Wang
- Y Wang
- Y Wei
- Y Wei
- Y Wu
- Y Wu
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhao
- Y Zheng
- YE Henrotin
- YF Chu
- YH Lee
- YH Suh
- YH Wei
- YJ Surh
- YJ Surh
- YJ Surh
- YK Wu
- YM Kim
- YS Keum
- YS Sohn
- YX Ma
- YZ Fang
- Z Cai
- Z Cai
- Z Cheng
- Z Pei
- Z Serdar
- Z Tong
- Z Tong
- Z Yu
- Z Zhang
- ZD Liu
- ZD Liu
- ZE Karanjawala
- ZE Suntres
- ZI Cabantchik
- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Allgemeine Untersuchung und Behandlung vor und nach herzchirurgischen Eingriffen
- Author
- A Aris
- A Gehrke
- A Oberman
- A Righetti
- A Salama
- AJ Ominsky
- AJ Roberts
- AM Katz
- AP Niarchos
- AW Karchmer
- B Friedly
- B Kunkel
- B Vidne
- BC Morton
- BH Bulkley
- BJ Messmer
- BM Chesnie
- BR Caitman
- BR Logue
- C Prys-Roberts
- C Prys-Roberts
- CH Gohlke-Bärwolf
- CL Sarin
- D Behrendt
- D Horstkotte
- D Horstkotte
- D Horstkotte
- D Horstkotte
- D Horstkotte
- D Horstkotte
- D Horstkotte
- D Horstkotte
- DA Barnhorst
- DA Rubin
- DC Finlayson
- Deutsche Gesellschaft für Herz- und Kreislaufforschung Kommission für Klinische Kardiologie
- DG Lappas
- DH Blankenhorn
- DJ Coltart
- DM Cosgrove
- DW Miller
- DW Westring
- E Struck
- EB Stinson
- F Loogen
- FG Estefanous
- G Csapo
- G Gossius
- GA Porter
- GJ Reul
- GJ Reul
- GW Olinger
- H Gohlke
- H Gohlke
- H Gohlke
- H Masur
- H Mattern
- H Roskamm
- HD Mcintosh
- HN Hultgren
- J Dale
- J Morrison
- J Washington
- JA D’cruz
- JA Kaplan
- JA Kaplan
- JA Kaplan
- JC Griffin
- JC Sill
- JE Dimmick
- JF Viljoen
- JG Bhat
- JH Chesebro
- JH Tinker
- JJ Stockard
- JL Assad-Morell
- JL Bennett
- JL Clerc Le
- JM Moran
- JM Sullivan
- JP Schranck
- JR Burton
- JS Douglas
- JT Lie
- JU Balis
- JW Kirklin
- KH Mayer
- KL Froer
- KR Weeks
- KV Arom
- L Hannson
- L Slaughter
- LJ Bonchek
- LW Johnson
- M Turina
- MA Branthwaite
- MA Engle
- MA Engle
- MAJ Weber
- MF Beynen
- ML Meistrell
- MR Rose
- MS Sweeney
- MTH Brodeur
- MV Sherrid
- NO Fowler
- NT Kouchoukos
- P Bedard
- P Simpkin
- PA Southorn
- PA Southorn
- PC Block
- PD Myerowitz
- PH Rogers
- PK Caves
- PL Klineberg
- R Bayliss
- R Collins
- R Conti
- R Kuhnt
- R Shabetai
- RA Langou
- RB Karp
- RB Shafer
- RD Floyd
- RD Weisel
- RJ Gray
- RM Abel
- RN Peters
- RN Sapsford
- RO Russel
- RR Miller
- RW Quenzer
- S Goldman
- S Kellner
- S Slogoff
- S Slogoff
- SP Reddy
- T Aberg
- T Gelehrter
- TA Raab
- TJ Bixler
- TJ Yeh
- TP Chee
- U Bortolotti
- V Gallna
- VO Björk
- VO Björk
- W Robinson
- WA Pettinger
- WB Firor
- WJ Pories
- WR Wilson
- WW Angell
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
Mechanism of superoxide anion-induced modulation of vascular tone
- Author
- AA Hagen
- AE Ali
- AP Southorn
- B Halliwell
- B Hammond
- BR Lucchesi
- BS Lamb
- C Ingerman-Wojenski
- C Marshall
- C Ventura
- CG Schnackenberg
- D Ganten
- D Rowley
- DG Harrison
- DJ Webb
- DL Lawson
- DW Laight
- F Constention
- GM Rubanyi
- Goodman
- H Heinle
- H Wang Di
- HA Kontos
- HA Kontos
- HB Li
- HP Souza
- J Kahler
- J Kalra
- J Martinez
- JA Saye
- JD Swales
- JG DeMay
- JG DeMay
- JL Archer
- JL Szarek
- JM McCord
- K Prasad
- K Prasad
- K Prasad
- K Prasad
- K Prasad
- K Prasad
- K Prasad
- KE Weir
- KF Ng
- KM Mohazzab-H
- KW Hong
- L Bharadwaj
- L Bharadwaj
- L Raij
- L Wu
- L Wu
- LX Lilley
- M Yanagisawa
- MC Hess
- MC Toufektsian
- MS Wolin
- N Weissmann
- PD Cherry
- PJ Silin
- RA Rhoades
- RA Rhoades
- RF Maestro Del
- RJ Altiere
- RJ Krothuis
- RL Baehner
- RM Tate
- RP Kaufman
- S Pomposiello
- S Sugiyama
- SA Gupte
- SL Lee
- SL Peters
- SR Jolly
- T Liu
- T Liu
- T Mori
- T Murohara
- TJ Rimele
- TM Hollis
- W Auch-Schwelk
- WI Rosenblum
- WM Armstead
- WW Daniel
- ZS Katusic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Oxidant injury in coronary heart disease [Part-1]
- Author
- A Arduini
- A Bast
- A Blann
- A Kooij
- A Lugasi
- A Novogrodsky
- A Sabri
- AG Lenz
- AI Olesin
- AI Olesin
- AJ Liedtke
- AM Zeiher
- AP Metinko
- AS Blaustein
- AV Efremov
- AV Tuev
- B Gressier
- C Coudray
- C Garcia-Ruiz
- C Steenbergen
- CM Tan
- D Lapenna
- D Popovici
- D Smith
- DA Loeffler
- DE Wesson
- Dipak P. Pandya
- DM Hockenberry
- DP Pandya
- EA Koniurev
- EH Jang
- EJ Zarling
- F Konrad
- FJ Walther
- FZ Meerson
- G Luc
- GD Duthie
- GG Duthie
- GG Konovalova
- GM McGuire
- GS Voronkov
- H Jaarsveld Van
- H Jaeschke
- H Ooiwa
- HK TM WB Im
- JA Post
- JC Tardif
- JC Tardif
- JE Ahlskog
- JH Doroshow
- JHM Prehn
- JL Wautier
- JM McCord
- JMC Gutteridge
- JR Sanchez Ramus
- K Kugiyama
- K Morita
- K Ytrehus
- KK Greindling
- L Raij
- LD Deleve
- LH Opie
- M Valenza
- MA Cotter
- MF Oliver
- MN Diaz
- MR Mehra
- MV Bilenko
- N Gokce
- PA Sobotka
- PA Southorn
- PB Addis
- PJ Simpson
- PS Haddock
- R Ferrari
- R Ferrari
- R Olinescu
- R Schulz
- RA Frol'kis
- RA Kloner
- RC Bruch
- RE Bellas
- RR Gilmot
- S Devaraj
- S Kemimura
- S Rangaswamy
- S Teramoto
- S Yanagida
- SJ Elliott
- SJ Elliott
- SK Koliward
- SM Lynch
- SM Pognized
- SP Andreoli
- TM Buttke
- TW Robison
- UP Steinbrecher
- VL Kinnula
- WP Schilling
- X Wu
- Y Rojanaskul
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study