11 research outputs found
Protein labeling with the labeling precursor [18F]SiFA-SH for positron emission tomography
Automated synthesis of [18F]Ga-rhPSMA-7/ -7.3: results, quality control and experience from more than 200 routine productions
Synthesis of [18F]SiFB: a prosthetic group for direct protein radiolabeling for application in positron emission tomography
Contemporary Technology for Preparing Fiber-Reinforced Composite Materials with a Ceramic Refractory Matrix (Review)
One-step 18F-labeling of peptides for positron emission tomography imaging using the SiFA methodology
Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma
Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors
Using 5-deoxy-5-[18F]fluororibose to glycosylate peptides for positron emission tomography
18F-labelling innovations and their potential for clinical application
An impressive variety of new methodologies for the preparation of 18F-labelled tracers and ligands has appeared over the last decade. Most strategies of the newly developed radiofluorination methods predominantly aim at products of high molar activity by ‘late-stage’ labelling of small (hetero)aromatic molecules and the use of transition metals. This is accompanied by the improvement of technical procedures, like preparation of reactive [18F]fluoride and automated syntheses. The newly introduced procedures reflect a high innovative level and creativity in radio(pharmaceutical) chemistry at present, which are based on modern chemical methods and deep mechanistic insights. Taking also automation and quality control into consideration, major recently developed radiofluorination methods, most of those still under development, are compiled here in view of their potential for clinical PET imaging and thus the ability to advance molecular imaging