5 research outputs found
Clusia criuva Cambess. (Clusiaceae): anatomical characterization, chemical prospecting and antioxidant activity
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
ABSTRACT This study aims the anatomical description and chemical characterization of aerial parts of Clusia criuva Cambess., Clusiaceae in addition to the evaluation of the antioxidant activity of crude extracts, correlated to the flavonoid content. The morphological characterization was performed using traditional techniques of plant anatomy. For phytochemical studies, crude extracts were obtained by static maceration and analyzed by thin layer chromatography. The antioxidant activity and the flavonoids content were determined by colorimetric methods involving, respectively, 2,2-diphenyl-1-picrylhydrazyl free radical and aluminum chloride. C. criuva has uniseriate epidermis, paracytic stomata, hypostomatic leaves, cuticular flanges and cordiform vascular cylinder with accessory bundles. Chemical prospecting confirmed the abundant presence of terpenes and phenols in the extracts of leaves and of fruits. The methanolic extract of seeds showed the lowest EC50 value, but the methanolic extract of pericarps exhibited the highest maximum antioxidant activity. The results suggested a high percentage of flavonoids in the hexanic extract of pericarps, however, this could represent, in fact, the presence of benzophenones. Secretory ducts and the shape of the midrib are diagnostic for C. criuva. The antioxidant activity is not directly related to the flavonoids. The results indicate the importance of future studies with C. criuva chemical constituents
Clusia criuva Cambess. (Clusiaceae): anatomical characterization, chemical prospecting and antioxidant activity
- Author
- ADRIANA Q. LOBĂO
- ALESSANDRA L. VALVERDE
- AMARAL LIV
- AMIÄ D
- ANA JOFFILY
- ANDRADE MR
- ANDREA B. DA NĂBREGA
- BARTHLOTT W
- BOEGER MRT
- BRUNO LESSA
- BURGER LM
- CAVALCANTE PB
- CHANG CC
- CHEDIER LM
- COELHO VPM
- COELHO-FERREIRA M
- COHEN J
- COMPAGNONE RS
- DEGĂSPARI CH
- EDWARDS C
- ESAU K
- FARNSWORTH NR
- FERNANDES SDC
- FERREIRA RO
- FILHO DBF
- GUIMARĂES AG
- GUIMARĂES ALA
- JOHANSEN DA
- JUDD WS
- KARLA M.M. DA SILVA
- KLEIN DE
- LOKVAM J
- MARIA CAROLINA ANHOLETI
- MARINI-BETTĂLO GB
- MEDINA E
- MEDINA E
- MENSOR LL
- METCALFE CR
- MONTANARI CA
- MOREAU P
- NOGUEIRA PC
- NOLDIN VF
- ODONNE G
- OLIVEIRA CMA
- OLIVEIRA CMA
- OLIVEIRA RF
- OPSAHL S
- PAULA JE
- PENG ZF
- PIETTA PG
- PORTO ALM
- PROESTOS C
- ROCHA DI
- RUFINO MSM
- SANCHO MI
- SANT'ANNA-SANTOS BF
- SCHNEIDER SZ
- SELMA R. DE PAIVA
- SEO EK
- SEYOUM A
- SILVA C
- SILVA LC
- SILVA MC
- SILVA MCA
- SOUSA CMM
- STEVENS PF
- TAVARES LHC
- VALADEAU C
- VAN ACKER SA
- VIRGINIO MCAS
- WAGNER HM
- WITTSTOCK U
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Early-age Acute Leukemia: Revisiting Two Decades of the Brazilian Collaborative Study Group
- Author
- Alejandro Mauricio Arancibe
- Alexander
- Alexandre Apa
- Ana Freund Winn
- Ana M. Marinho da Silva
- Andersson
- Andrade
- Andrade
- Andrade
- Andrea Gadelha NĂłbrega
- Anna Carolina Silva Dias
- Arber
- Armstrong
- Atalla Mnayarji
- Babovic
- Balgobind
- Barletta
- Bhojwani
- Biondi
- Bolufer
- Bowie
- Brisson
- Bruno M. Rocha Freire
- Carroll
- Chaudhury
- Chessells
- Chokkalingam
- Cimino
- Claudia Teresa Oliveira
- Coenen
- Costa
- Couto
- Creutzig
- Curado
- Cyntia Curvello
- CĂłser
- De Souza Reis
- Denise B. Silva
- Driessen
- Eaves
- Elaine Sobral da Costa
- Eloisa Cartaxo Eloy Fialho
- Emerenciano
- Emerenciano
- Emerenciano
- Emerenciano
- Emerenciano
- Emerenciano
- Emerenciano
- Eny GuimarĂŁes Carvalho
- Ferman
- Fernando de Almeida Wernerck
- Ferreira
- Ferreira
- Ferreira
- Filiberto
- Flavia Nogueira Serafim Araujo
- Ford
- Francianne Gomes Andrade
- Gilberto Ramos
- Greaves
- Greaves
- Gruber
- Gustavo Ribeiro Neves
- Huen
- ImaruĂ Costa
- Inaba
- Isaacs
- Isis M. Quezado MagalhĂŁes
- Joaquim Caetano Aguirre
- Jose Carlos Martins Cordoba
- Jozina Marian de Andrade Agareno
- Kasat
- Kelly
- Koifman
- Lauten
- Liang
- Lilian Maria Burlachini
- Lilian Maria Cristofani
- Lopes
- Mansur
- Mansur
- Mara Albonei Dudeque Pianovski
- Marcelo dos Santos Souza
- Marcelo Land
- Maria Dolores Dorea
- Maria Lucia Marinho Lee
- Maria Luiza Macedo Silva
- Maria S. Pombo-de-Oliveira
- Mariana Emerenciano
- Marschalek
- Masetti
- Masetti
- Mata
- MaurĂcio de Souza Meire
- Meyer
- Meyriele Bacarini Machado
- Monica Lankszner
- Mori
- Moura
- Nilma Pimentel de Brito
- Patricia Carneiro de Brito
- Paulo Ivo Cortez de Araujo
- Perera
- Pieters
- Pombo de Oliveira
- Pombo-de-Oliveira
- Poole
- Prelle
- Pui
- Reichel
- Renata S. Carvalho Gurgel
- Renato de Paula Guedes Oliveira
- Renato Melaragno
- Rodriguez-Galindo
- Rosania M. Baseggio
- Ross
- Ross
- Rössler
- Schnyder
- Sergio Koifman
- Silvia R. Brandalise
- Smith
- Soraya Rouxinol
- Stiller
- Taketani
- Teresa Cristina Cardoso
- Terezinha J. Marques Salles
- Tosi
- Udroiu
- Valentine
- Van der Linden
- Vanhees
- Vasiliou
- Vitoria Regia Pinheiro
- Von Bergh
- Wellington Mendes
- Wiemels
- Wiemels
- Zanrosso
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
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- Agocha A
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- Ahmed A
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- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
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- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
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- Amidon T
- Amos M
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- Andrade G
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- Zweiker R
- Ă ngman K
- Ădes I
- Ăstberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P AntĂŽnio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- AntĂłnio M Alvarez
- AntĂłnio M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
- Behzad Nadjm
- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
- Brit Ă SjĂžbĂž
- Bruno Franco Mazza
- Bruno Gelée
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- Candelaria De Haro
- Carlo A Volta
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- Caroline Berghe
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- Cesar Milstein
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- Charlene Bigot
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- Chern Min Voon
- Cheryl Padilla-Harris
- Chinni Krishna Kasi
- Chloe Hughes
- Christian C Rylander
- Christian Dellera
- Christian Frey
- Christian M Ramirez-Alfaro
- Christian Schlegel
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- Claudio Piras
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- Colette Seasman
- Colette Seasman
- Colin K Grissom
- Colin Mcarthur
- Colin S Black
- Cora Lavigne Moreira
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristiane Ritter
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- Cristina M Cox
- Cristina Prata Amendola
- Cristina Santos
- Cristina Santos
- CĂ©dric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Dalton de Souza Barros
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel AragĂŁo
- Daniel Beraldo
- Daniel Collins
- Daniel da Cunha Ribeiro
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- Daniel Hadfield
- Daniel Hull
- Daniel O Beraldo
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- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
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- Daniele M Combaux
- Danielle A Fawkes
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- Debbie Weller
- Deborah M Inskip
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- Denise Griffin
- Dharshinie Dorasamy
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman B Pg Hj Ismail
- Donald A Irvine
- Donall O'Croinin
- Donatella Mestria
- Dora Mannarino
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- DĂĄcil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
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- Eimhin S Dunne
- Eizo Watanabe
- Elaine Ferreira
- Eldar SĂžreide
- Electra E Stamou
- Elena Frati
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- Eliezer Silva
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- Emanuel Cirstea
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- Eoin Young
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- Erin Nishikawa
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- Ferdinando Raimondi
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- Fernando Borges Rodriguez
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- Fernando José da Silva Ramos
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Flavia Ribeiro Machado
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- Francesco Mojoli
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- Fredrik Schiöler
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- Gabriele Sales
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- Gaetan BĂ©duneau
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- Gautier Buzancais
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- Ged Dempsey
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- Ghassan Kamel
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- Giacomo Monti
- Gianluca Zani
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- Gilda Cinnella
- Giorgio A Iotti
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- Guillermo Bugedo
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- Gulay Eren
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- Gustavo Pittini
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- Gyan Kayashta
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- Vesna Bumbasirevic
- Vicente CĂ©s de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin DemirtĂŒrk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ălvaro RĂ©a-Neto
- Ăngela Algaba
- Ăngela GonzĂĄlez-Salamanca
- Ăiler Zincircioglu
- Ărica Aranha Suzumura
- Ănio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status