Superconductivity in CoO2_2 Layers and the Resonating Valence Bond Mean Field Theory of the Triangular Lattice t-J model

Motivated by the recent discovery of superconductivity in two dimensional CoO$_2$ layers, we present some possibly useful results of the RVB mean field theory applied to the triangular lattice. Away from half filling, the order parameter is found to be complex, and yields a fully gapped quasiparticle spectrum. The sign of the hopping plays a crucial role in the analysis, and we find that superconductivity is as fragile for one sign as it is robust for the other. Na$_x$CoO$_2\cdot y$H$_2$O is argued to belong to the robust case, by comparing the LDA Fermi surface with an effective tight binding model. The high frequency Hall constant in this system is potentially interesting, since it is pointed out to increase linearly with temperature without saturation for T $>$ T$_{degeneracy}$.Comment: Published in Physical Review B, total 1 tex + 9 eps files. Erratum added as separate tex file on November 7, 2003, a numerical factor corrected in the erratum on Dec 3, 200

Absence of classical and quantum mixing

It is shown, under mild assumptions, that classical degrees of freedom dynamically coupled to quantum ones do not inherit their quantum fluctuations. It is further shown that, if the assumptions are strengthen by imposing the existence of a canonical structure, only purely classical or purely quantum dynamics are allowed.Comment: REVTeX, 4 page

Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy

Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur. However, in less experienced hands, this technique yields considerable variability in fracture pattern and requires highly-specialized equipment. This study describes a reproducible and low-cost model of mouse fracture healing using an open femoral osteotomy. Methods: Femur fractures were produced in skeletally mature male and female mice using an open femoral osteotomy after intramedullary stabilization. Mice were recovered for up to 28 days prior to analysis with microradiographs, histomorphometry, a novel μCT methodology, and biomechanical torsion testing at weekly intervals. Results: Eight mice were excluded due to complications (8/193, 4.1%), including unacceptable fracture pattern (2/193, 1.0%). Microradiographs showed progression of the fracture site to mineralized callus by 14 days and remodelling 28 days after surgery. Histomorphometry from 14 to 28 days revealed decreased cartilage area and maintained bone area. μCT analysis demonstrated a reduction in mineral surface from 14 to 28 days, stable mineral volume, decreased strut number, and increased strut thickness. Torsion testing at 21 days showed that fractured femurs had 61% of the ultimate torque, 63% of the stiffness, and similar twist to failure when compared to unfractured contralateral femurs. Conclusions: The fracture model described herein, an open femoral osteotomy, demonstrated healing comparable to that reported using closed techniques. This simple model could be used in future research with improved reliability and reduced costs compared to the current options

Nematode movement along a chemical gradient in a structurally heterogeneous environment : 2. Theory

L'influence de l'hétérogénéité sur la diffusion chimique et le déplacement des nématodes est étudiée par le biais d'un modèle théorique. Ce modèle prend en compte trois facteurs influant sur le déplacement des nématodes : la structure du sol, la stratégie de recherche de nourriture et la chémotaxie. Utilisant un modèle continu, nous avons mis au point un système discret permettant de simuler les traces des nématodes dans chacune des quatre situations définies par Anderson et al. (1997). Nous avons montré que l'hétérogénéité structurale provoque aussi bien des taux variables de concentrations du composé attractif dans des aires réduites que la reconnaissance de ce composé. L'hétérogénéité structurale du sol limite également la stratégie de recherche de nourriture du nématode lequel adopte alors une stratégie permettant d'éviter les pièges structuraux. Il est démontré que des augmentations localisées de la densité structurale accroissent significativement la reconnaissance du composé attractif. (Résumé d'auteur

Nematode movement along a chemical gradient in a structurally heterogeneous environment : 1 . Experiment

L'interaction entre l'hétérogénéité structurale et les gradients chimiques, ainsi que leur influence sur le déplacement des nématodes, ont été étudiées. Trois dispositifs expérimentaux ont été utilisés qui comprennent un nématode (#Caenorhabditis elegans) placé sur une couche homogène de milieu nutritif gélosé dans une boîte de Petri avec ou sans présence d'une source bactérienne de nourriture (#Escherichia coli) utilisée comme attractif. L'hétérogénéité structurale est réalisée en ajoutant des grains de sable en une seule épaisseur dans chacun des traitements homologues. Toutes les traces ont été relevées à l'aide d'un dispositif de vidéo à séquences temporelles et les données digitalisées avant analyse. Les répartitions des angles de changement de direction et les dimensions fractales des traces sont calculées pour chaque traitement. Il se révèle un effet statistiquement significatif (P inférieur ou égal à 0,01) de tous les traitements sur le déplacement des nématodes. En présence d'un produit attractif, le déplacement du nématode est plus linéaire et dirigé vers la source bactérienne. L'hétérogénéité structurale provoque un déplacement plus linéaire que dans le cas d'un milieu homogène. La dimension fractale des traces du nématode est significativement (P inférieur ou égal à 0,01) plus élevée pour les traitements sans sable ni bactéries que pour les autres traitements. Ces résultats permettent, pour la première fois, de quantifier le degré auquel les nématodes utilisent un comportement de recherche de nourriture au hasard dans un milieu homogène et adoptent un déplacement mieux orienté en présence d'un produit attractif. Finalement, lorsqu'une hétérogénéité est présente, la stratégie de recherche de nourriture devient plutôt une stratégie d'évitement permettant au nématode d'échapper aux "pièges" structuraux, tels les pores en cul-de-sac, et de pouvoir ainsi continuer à réagir à l'attraction. (Résumé d'auteur

Shape Space Methods for Quantum Cosmological Triangleland

With toy modelling of conceptual aspects of quantum cosmology and the problem of time in quantum gravity in mind, I study the classical and quantum dynamics of the pure-shape (i.e. scale-free) triangle formed by 3 particles in 2-d. I do so by importing techniques to the triangle model from the corresponding 4 particles in 1-d model, using the fact that both have 2-spheres for shape spaces, though the latter has a trivial realization whilst the former has a more involved Hopf (or Dragt) type realization. I furthermore interpret the ensuing Dragt-type coordinates as shape quantities: a measure of anisoscelesness, the ellipticity of the base and apex's moments of inertia, and a quantity proportional to the area of the triangle. I promote these quantities at the quantum level to operators whose expectation and spread are then useful in understanding the quantum states of the system. Additionally, I tessellate the 2-sphere by its physical interpretation as the shape space of triangles, and then use this as a back-cloth from which to read off the interpretation of dynamical trajectories, potentials and wavefunctions. I include applications to timeless approaches to the problem of time and to the role of uniform states in quantum cosmological modelling.Comment: A shorter version, as per the first stage in the refereeing process, and containing some new reference

Strategic priorities for respiratory syncytial virus (RSV) vaccine development

AbstractAlthough RSV has been a high priority for vaccine development, efforts to develop a safe and effective vaccine have yet to lead to a licensed product. Clinical and epidemiologic features of RSV disease suggest there are at least 4 distinct target populations for vaccines, the RSV naïve young infant, the RSV naïve child ≥6 months of age, pregnant women (to provide passive protection to newborns), and the elderly. These target populations raise different safety and efficacy concerns and may require different vaccination strategies. The highest priority target population is the RSV naïve child. The occurrence of serious adverse events associated with the first vaccine candidate for young children, formalin inactivated RSV (FI-RSV), has focused vaccine development for the young RSV naïve child on live virus vaccines. Enhanced disease is not a concern for persons previously primed by a live virus infection. A variety of live-attenuated viruses have been developed with none yet achieving licensure. New live-attenuated RSV vaccines are being developed and evaluated that maybe sufficiently safe and efficacious to move to licensure. A variety of subunit vaccines are being developed and evaluated primarily for adults in whom enhanced disease is not a concern. An attenuated parainfluenza virus 3 vector expressing the RSV F protein was evaluated in RSV naïve children. Most of these candidate vaccines have used the RSV F protein in various vaccine platforms including virus-like particles, nanoparticles, formulated with adjuvants, and expressed by DNA or virus vectors. The other surface glycoprotein, the G protein, has also been used in candidate vaccines.We now have tools to make and evaluate a wide range of promising vaccines. Costly clinical trials in the target population are needed to evaluate and select candidate vaccines for advancement to efficacy trials. Better data on RSV-associated mortality in developing countries, better estimates of the risk of long term sequelae such as wheezing after infection, better measures of protection in target populations, and data on the costs and benefits of vaccines for target populations are needed to support and justify funding this process. Addressing these challenges and needs should improve the efficiency and speed of achieving a safe and effective, licensed RSV vaccine

Unitarity Restoration in the Presence of Closed Timelike Curves

A proposal is made for a mathematically unambiguous treatment of evolution in the presence of closed timelike curves. In constrast to other proposals for handling the naively nonunitary evolution that is often present in such situations, this proposal is causal, linear in the initial density matrix and preserves probability. It provides a physically reasonable interpretation of invertible nonunitary evolution by redefining the final Hilbert space so that the evolution is unitary or equivalently by removing the nonunitary part of the evolution operator using a polar decomposition.Comment: LaTeX, 17pp, Revisions: Title change, expanded and clarified presentation of original proposal, esp. with regard to Heisenberg picture and remaining in original Hilbert spac

Transverse electrokinetic and microfluidic effects in micro-patterned channels: lubrication analysis for slab geometries

Off-diagonal (transverse) effects in micro-patterned geometries are predicted and analyzed within the general frame of linear response theory, relating applied presure gradient and electric field to flow and electric current. These effects could contribute to the design of pumps, mixers or flow detectors. Shape and charge density modulations are proposed as a means to obtain sizeable transverse effects, as demonstrated by focusing on simple geometries and using the lubrication approximation.Comment: 9 pages, 7 figure

Accelerated in situ bioremediation of groundwater

In situ bioremediation, as applied in this project, is based on the principal of biostimulation: supplying nutrients to indigenous microbes to stimulate their metabolic activity and subsequent degradation of contaminants. Typically, a network of injection and extraction wells are used to recirculate groundwater into which amendments are added and distributed within the aquifer. The objective of the in situ process is to create in the aquifer a microbially active zone that maximizes contaminant destruction while controlling the distribution of microbial growth. It is important to control microbial growth to avoid plugging the aquifer near the injection well and to establish and sustain maximum treatment zones for each injection well. Figure I illustrates this concept for in situ bioremediation. The technology described herein is innovative in its use of the computer-based Accelerated Bioremediation Design Tool (ABDT) to aid in selecting appropriate system designs and to determine optimal operating strategies. In addition, numerical simulations within the design tool proved to be valuable during remediation operations to determine appropriate changes in the` operating strategy as the bioremediation process progressed. This is particularly important because in situ bioremediation is not a steady- state process, and corrective actions to operating parameters are typically needed to maintain both rapid destruction rates and hydraulic containment