30 research outputs found

    Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier

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    Sensitivity, dynamic range and frequency tuning of the cochlea are attributed to amplification involving outer hair cell stereocilia and/or somatic motility. We measured acoustically and electrically elicited basilar membrane displacements from the cochleae of wild-type and TectaDeltaENT/DeltaENT mice, in which stereocilia are unable to contribute to amplification near threshold. Electrically elicited responses from TectaDeltaENT/DeltaENT mice were markedly similar to acoustically and electrically elicited responses from wild-type mice. We conclude that somatic, and not stereocilia, motility is the basis of cochlear amplification
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