Electrical characterization of micron sized chambers used as a depot for drug delivery

Implantable drug delivery devices have emerged as a quintessential therapeutic platform for curing chronic ailments that require enhanced and localized drug concentrations. A typical device encompasses an array of tiny reservoirs or chambers to store drug formulations before their release inside a biological milieu. With the recent progress in biocompatible and biodegradeable materials, it has become readily possible to fabricate chambers for rapid and on demand drug release. However, to deal with emerging diagnostic and therapeutic conundrum, new paradigms are required to devise chambers with multifunctional capabilities. In this paper, we present micron sized chambers that are fabricated by a patterned film base to realize their structure in an array formation. The microchambers are fabricated from polylactic acid matrix and modified with a range of conducting species using layer by layer assembly technique. For electrical response characterization of microchambers, complimentary split ring resonator is used to estimate the loss tangent. A proof of concept is also discussed that the conductive nature of microchambers can be envisioned to perform thermal therapy and drug delivery in response to electromagnetic radiations