Effectiveness of acupuncture, special dressings and simple, low-adherence dressings for healing venous leg ulcers in primary healthcare: study protocol for a cluster-randomized open-labeled trial

<p>Abstract</p> <p>Background</p> <p>Venous leg ulcers constitute a chronic recurring complaint that affects 1.0–1.3% of the adult population at some time in life, and which corresponds to approximately 75% of all chronic ulcers of the leg. Multilayer compression bandaging is, at present, the only treatment that has been proved to be effective in treating this type of ulcer. There is no consensus, however, about the dressings that may be applied, beneath the compression, to promote the healing of this type of ulcer, as there does not seem to be any added benefit from using special dressings rather than simple, low-adherence ones. As well as analgesia, acupuncture provokes peripheral vasodilation, in skin and muscles – which has been demonstrated both experimentally and in clinical practice – probably due to the axon reflex, among other mechanisms. The aim of the present study is to measure the effectiveness and cost of compression treatment for venous leg ulcers combined with special dressings, in comparison with low-adherence ones and acupuncture.</p> <p>Methods/design</p> <p>Cluster-randomized open-labeled trial, at 15 primary healthcare clinics in the Sevilla-Sur Healthcare District, with a control group treated with compression bandaging and low-adherence dressings; the experiment will consist, on the one hand, of the compression treatment applied in combination with special dressings (Treatment 1), and on the other, the compression treatment applied in association with low-adherence dressings, together with acupuncture (Treatment 2).</p> <p>Discussion</p> <p>The results will be measured and recorded in terms of the median time elapsed until complete healing of the ulcer, and the rate of complete healing at 3 months after beginning the treatment. An economic analysis will also be made.</p> <p>This study, carried out in the context of real clinical practice, will provide information for decision-taking concerning the effectiveness of special dressings. Moreover, for the first time a high-quality study will evaluate the effectiveness of acupuncture in the process of healing venous leg ulcers.</p> <p>Trial registration</p> <p>Current Controlled Trials ISRCTN26438275.</p

Nature meets nurture: molecular genetics of gastric cancer

The immensity of genes and molecules implicated in gastric carcinogenesis is overwhelming and the relevant importance of some of these molecules is too often unclear. This review serves to bring us up-to-date with the latest findings as well as to look at the larger picture in terms of how to tackle the problem of solving this multi-piece puzzle. In this review, the environmental nurturing of intestinal cancer is discussed, beginning with epidemiology (known causative factors for inducing molecular change), an update of H. pylori research, including the role of inflammation and stem cells in premalignant lesions. The role of E-cadherin in the nature (genotype) of diffuse gastric cancer is highlighted, and finally the ever growing discipline of SNP analysis (including IL1B) is discussed

Sobrepeso e obesidade em escolares brasileiros de sete a nove anos: dados do projeto Esporte Brasil Overweight and obesity in seven to nine-year-old Brazilian students: data from the Brazilian Sports Project

OBJETIVO: Descrever a prevalência de sobrepeso e obesidade em escolares brasileiros de sete a nove anos e verificar a associação com as variáveis: sexo, idade e região geográfica. MÉTODOS: Estudo epidemiológico transversal conduzido em 2.913 escolares (1.478 do sexo masculino e 1.435 do feminino) com idade entre sete e nove anos. Como critério de diagnóstico de sobrepeso e obesidade foram utilizados os pontos de corte do índice de massa corpórea, propostos pela International Obesity Task Force. A comparação entre as proporções foi realizada mediante o teste qui-quadrado. As diferenças entre as proporções foram testadas por meio do teste de comparação entre duas proporções. RESULTADOS: A prevalência de sobrepeso e obesidade foi de 15,4 e 7,8% em meninos e meninas, respectivamente, com proporções similares entre sexo e idades. No sexo masculino, foi verificada associação do sobrepeso e obesidade apenas com região geográfica (p<0,001), com prevalências mais elevadas nas crianças da região Sul. No feminino, sobrepeso mais elevado foi observado nas crianças de sete anos da região Norte, enquanto a prevalência de obesidade foi maior nas crianças da região Sul. CONCLUSÕES: As crianças da região Sul apresentam maiores prevalências de sobrepeso e obesidade que aquelas das demais regiões do país. Os achados do presente estudo apontam uma tendência de aumento na prevalência de sobrepeso e obesidade na infância e corroboram os resultados encontrados em pesquisas mais abrangentes realizadas no Brasil.<br>OBJECTIVES: To describe the prevalence of overweight and obesity in Brazilian schoolchildren aged 7 to 9 years and determine its association with gender, age and geographic region. METHODS: This cross-sectional epidemiological study enrolled 2,913 students (1,478 boys and 1,435 girls) aged 7 to 9 years and was conducted between 2004 and 2005. The body mass index cutoff values proposed by the International Obesity Task Force were used as a diagnostic criterion for overweight and obesity. The chi-square test was used for comparison of proportions, and differences in prevalence rates were determined by testing for comparison between two proportions. RESULTS: The prevalence of overweight and obesity was 15.4% and 7.8% in boys and girls, respectively, with similar proportions in both genders and across all ages. In boys, overweight and obesity were only associated with geographic region (p<0.001), with a higher prevalence found in children from the South region. In girls, the prevalence of overweight was highest among those aged 7 years and those from the North region. In addition, an overall higher prevalence of obesity was observed among children from the South region. CONCLUSIONS: Schoolchildren from the South region of Brazil have a higher prevalence of overweight and obesity than those from other areas of the country. We conclude that overweight and obesity in childhood are on an upward trend, and our findings corroborate the results reported in other Brazilian studies