19 research outputs found
Abordagem do câncer da boca: uma estratégia para os níveis primário e secundário de atenção em saúde
Investigating the Protective Role of Death Receptor 3 (DR3) in Renal Injury Using an Organ Culture Model
CELL INFILTRATEN PROGRESSIVE PIGMENTED PURPURA (SCHAMBERG'S DISEASE): IMMUNOPHENOTYPE, ADHESION RECEPTORS, AND INTERCELLULAR RELATIONSHIPS
Myofibroblasts in Phenytoin-Induced Hyperplastic Connective Tissue in the Rat and in Human Gingival Overgrowth
PHARMACOLOGIC MODULATION BY CETIRIZINE OF SOME ADHESION MOLECULES EXPRESSION IN PSORIATIC SKIN LESIONS
Trends and correlation of antibacterial usage and bacterial resistance: time series analysis for antibacterial stewardship in a Chinese teaching hospital (2009–2013)
The Prevalence of Self-Reported Halitosis and Oral Hygiene Practices among Libyan Students and Office Workers
Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors
GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis
Progressive liver fibrosis is characterized by the deposition of collagen by activated hepatic stellate cells (HSCs). Activation of HSCs is a multiple receptor-driven process in which profibrotic signals are enhanced, and anti-fibrotic pathways are suppressed. Here we report the discovery of a novel signaling platform comprised of G protein subunit, Gαi and GIV, its guanine exchange factor (GEF), which serves as a central hub within the fibrogenic signalling network initiated by diverse classes of receptors. GIV is expressed in the liver after fibrogenic injury and is required for HSC activation. Once expressed, GIV enhances the profibrotic (PI3K-Akt-FoxO1 and TGFβ-SMAD) and inhibits the anti-fibrotic (cAMP-PKA-pCREB) pathways to skew the signalling network in favor of fibrosis, all via activation of Gαi. We also provide evidence that GIV may serve as a biomarker for progression of fibrosis after liver injury and a therapeutic target for arresting and/or reversing HSC activation during liver fibrosis