50 research outputs found
Physical realization of coupled Hilbert-space mirrors for quantum-state engineering
Manipulation of superpositions of discrete quantum states has a mathematical
counterpart in the motion of a unit-length statevector in an N-dimensional
Hilbert space. Any such statevector motion can be regarded as a succession of
two-dimensional rotations. But the desired statevector change can also be
treated as a succession of reflections, the generalization of Householder
transformations. In multidimensional Hilbert space such reflection sequences
offer more efficient procedures for statevector manipulation than do sequences
of rotations. We here show how such reflections can be designed for a system
with two degenerate levels - a generalization of the traditional two-state atom
- that allows the construction of propagators for angular momentum states. We
use the Morris-Shore transformation to express the propagator in terms of
Morris-Shore basis states and Cayley-Klein parameters, which allows us to
connect properties of laser pulses to Hilbert-space motion. Under suitable
conditions on the couplings and the common detuning, the propagators within
each set of degenerate states represent products of generalized Householder
reflections, with orthogonal vectors. We propose physical realizations of this
novel geometrical object with resonant, near-resonant and far-off-resonant
laser pulses. We give several examples of implementations in real atoms or
molecules.Comment: 15 pages, 6 figure
Focusing and Compression of Ultrashort Pulses through Scattering Media
Light scattering in inhomogeneous media induces wavefront distortions which
pose an inherent limitation in many optical applications. Examples range from
microscopy and nanosurgery to astronomy. In recent years, ongoing efforts have
made the correction of spatial distortions possible by wavefront shaping
techniques. However, when ultrashort pulses are employed scattering induces
temporal distortions which hinder their use in nonlinear processes such as in
multiphoton microscopy and quantum control experiments. Here we show that
correction of both spatial and temporal distortions can be attained by
manipulating only the spatial degrees of freedom of the incident wavefront.
Moreover, by optimizing a nonlinear signal the refocused pulse can be shorter
than the input pulse. We demonstrate focusing of 100fs pulses through a 1mm
thick brain tissue, and 1000-fold enhancement of a localized two-photon
fluorescence signal. Our results open up new possibilities for optical
manipulation and nonlinear imaging in scattering media
Estimating EQ-5D utilities based on the Short-Form Long Term Conditions Questionnaire (LTCQ-8)
Purpose: The aim of this work was to develop a mapping algorithm for estimating EuroQoL 5 Dimension (EQ-5D) utilities from responses to the Long-Term Conditions Questionnaire (LTCQ), thus increasing LTCQ’s potential as a comprehensive outcome measure for evaluating integrated care initiatives. Methods: We combined data from three studies to give a total sample of 1334 responses. In each of the three datasets, we randomly selected 75% of the sample and combined the selected random samples to generate the estimation dataset, which consisted of 1001 patients. The unselected 25% observations from each dataset were combined to generate an internal validation dataset of 333 patients. We used direct mapping models by regressing responses to the LTCQ-8 directly onto EQ-5D-5L and EQ-5D-3L utilities as well as response (or indirect) mapping to predict the response level that patients selected for each of the five EQ-5D-5L domains. Several models were proposed and compared on mean squared error and mean absolute error. Results: A two-part model with OLS was the best performing based on the mean squared error (0.038) and mean absolute error (0.147) when estimating the EQ-5D-5L utilities. A multinomial response mapping model using LTCQ-8 responses was used to predict EQ-5D-5L responses levels. Conclusions: This study provides a mapping algorithm for estimating EQ-5D utilities from LTCQ responses. The results from this study can help broaden the applicability of the LTCQ by producing utility values for use in economic analyses