24 research outputs found
Assessment of The Influence of Diabetes and Body Mass Index (BMI) on DNA Damage by Comet Assay in Hemodialysis Patients
Kronik Böbrek Yetmezlikli Hastalarda Hipertansiyon, Yaş ve Vücut kitle indeksinin Genetik Hasar Üzerine Etkisinin Mikronükleus Testi ile Değerlendirilmesi
Evaluation of the effect of hemoglobın, parathormon and ferritin levels on micronucleus frequency in hemodialysis patients
The Effect Of Hypertension And Body Mass Index On Sister Chromatid Exchange In Maintenance Hemodialysis Patients With Chronic Kidney Failure
A Case of an Accelerated Uremic Neuropathy
We present a 62-year-old man, with a prior history of diabetes mellitus, atherosclerotic heart disease, and chronic renal failure requiring peritoneal dialysis, who developed accelerated uremic sensorimotor polyneuropathy. Our patient significantly improved after effective hemodialysis. Although renal transplantation is a curable therapy for uremic neuropathy, effective dialysis is still an important treatment for the group of patients who cannot undergo renal transplantation
Diyabetik ve diyabetik olmayan kronik böbrek yetmezlikli hastalarda genetik hasarın mikronükleus testi ile belirlenmesi
Kronik Böbrek Yetmezliğine Yol Açan En Önemli İki Faktör: Diyabetin ve Hipertansiyonun Kromozom Anormallikleri Üzerine Etkileri
DNA damage in hemodialysis patients with chronic kidney disease; a test of the role of diabetes mellitus; a comet assay investigation
The incidence of chronic kidney disease (CKD) is increasing rapidly. Diabetes mellitus (DM) is the most important cause of CKD. We studied the possible role of DM in CKD patients with respect to DNA damage, as assessed by the comet assay in 60 CKD patients (with or without DM) undergoing hemodialysis and in 26 controls. Effects of other factors, such as age, sex, hypertension, duration of hemodialysis, body mass index (BMI), and levels of hemoglobin (HB), intact parathormone (iPTH), and ferritin (FER), were also examined. Primary DNA damage measured by the comet assay was significantly higher in CKD patients than in controls. Among CKD patients, the following correlations were observed. (1) There was no difference in comet tail length or tail intensity between diabetic and non-diabetic individuals. (2) Age, sex, hemoglobin, hypertension, duration of hemodialysis, and ferritin levels affected neither tail length nor intensity. (3) BMI values above 25 kg/m(2) and iPTH levels above 300 pg/ml were associated with significantly greater comet tail length. Our results indicate that primary DNA damage is increased in CKD patients undergoing hemodialysis, compared to controls; however, DM had no additional effect. (C) 2016 Published by Elsevier B.V