Patient Outcomes in Palliative Care - South Australia, July - December 2018

The Australian palliative care sector is a world leader in using routine clinical assessment information to guide patient centred care and measure patient and family outcomes. Providers of palliative care are commended for their commitment to excellence in delivering evidence-based, patient-centred care by using the routine Palliative Care Outcomes Collaboration (PCOC) assessment framework and contributing patient data toward national outcome measurement and benchmarking. PCOC acknowledges the dedication and willingness of clinicians to improve the care of patients, their families and caregivers. The information collected is not just data - it represents the real-life outcomes of over 40,000 Australians who die an expected death every year. While the focus of this report is on the most recent information relating to July to December 2018, results over the last three years are also presented to highlight achievements and improvement in outcomes. The most recent information corresponds to 23,333 patients, having 29,931 episodes of care and 70,135 palliative care phases from 127 services who provide palliative care in hospital / hospice or in the person\u27s home

A profile of patients receiving palliative care in Queensland for January - June 2019

The Palliative Care Outcomes Collaboration (PCOC) is a national program that aims to improve the quality and outcomes of palliative care in Australia. This is achieved via a standardised clinical language that supports a national data collection. This report provides a high level profile of 4,625 patients who received palliative care in Queensland during January to June 2019 and had their pain, symptom, family / carer and psychological / spiritual issues assessed as part of routine clinical care

A profile of patients receiving palliative care in Western Australia for January - June 2019

The Palliative Care Outcomes Collaboration (PCOC) is a national program that aims to improve the quality and outcomes of palliative care in Australia. This is achieved via a standardised clinical language that supports a national data collection. This report provides a high level profile of 4,181 patients who received palliative care in Western Australia during July to December 2018 and had their pain, symptom, family / carer and psychological / spiritual issues assessed as part of routine clinical care

Patient Outcomes in Palliative Care - NSW and ACT, January - June 2019

The Australian palliative care sector is a world leader in using routine clinical assessment information to guide patient centred care and measure patient and family outcomes. Providers of palliative care are commended for their commitment to excellence in delivering evidence-based, patient-centred care by using the routine Palliative Care Outcomes Collaboration (PCOC) assessment framework and contributing patient data toward national outcome measurement and benchmarking. PCOC acknowledges the dedication and willingness of clinicians to improve the care of patients, their families and caregivers. The information collected is not just data - it represents the real-life outcomes of over 40,000 Australians who die an expected death every year. While the focus of this report is on the most recent information relating to January to June 2019, results over the last three years are also presented to highlight achievements and improvement in outcomes. The most recent information corresponds to 24,562 patients, having 31,826 episodes of care and 73,209 palliative care phases from 138 services who provide palliative care in hospital / hospice or in the person\u27s home

Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration

The endothelial lining of the vasculature forms the physical barrier between the blood and underlying tissues. Junctions between adjacent endothelial cells are dynamically modulated to sustain vascular homeostasis and to support the transendothelial migration of leukocytes during inflammation. A variety of factors initiate intracellular signaling pathways which regulate the opening and resealing of junctional complexes. This review focuses on three primary signaling pathways initiated within endothelial cells by the binding of vasoactive factors and leukocyte adhesion: Rho GTPases, reactive oxygen species, and tyrosine phosphorylation of junctional proteins. These pathways converge to regulate junctional permeability, either by affecting the stability of junctional proteins or by modulating their interactions. Although much progress has been made in understanding the relationships of these pathways, many questions remain to be answered. A full understanding of the signaling cascades that affect endothelial junctions should identify novel therapeutic targets for diseases that involve excessive permeability or inappropriate leukocyte infiltration into tissues

Characterizing [C II] Line Emission In Massive Star Forming Clumps

Because the 157.74 micron [C II] line is the dominant coolant of star-forming regions, it is often used to infer the global star-formation rates of galaxies. By characterizing the [C II] and far-infrared emission from nearby Galactic star-forming molecular clumps, it is possible to determine whether extragalactic [C II] emission arises from a large ensemble of such clumps, and whether [C II] is indeed a robust indicator of global star formation. We describe [C II] and far-infrared observations using the FIFI-LS instrument on the SOFIA airborne observatory toward four dense, high-mass, Milky Way clumps. Despite similar far-infrared luminosities, the [C II] to far-infrared luminosity ratio, L([C II])/L(FIR) varies by a factor of at least 140 among these four clumps. In particular, for AGAL313.576+0.324, no [C II] line emission is detected despite a FIR luminosity of 24,000 L_sun. AGAL313.576+0.324 lies a factor of more than 100 below the empirical correlation curve between L([C II])/L(FIR) and S_\nu (63 micron)/S_\nu (158 micron) found for galaxies. AGAL313.576+0.324 may be in an early evolutionary "protostellar" phase with insufficient ultraviolet flux to ionize carbon, or in a deeply embedded ``hypercompact' H II region phase where dust attenuation of UV flux limits the region of ionized carbon to undetectably small volumes. Alternatively, its apparent lack of \cii\, emission may arise from deep absorption of the \cii\, line against the 158 micron continuum, or self-absorption of brighter line emission by foreground material, which might cancel or diminish any emission within the FIFI-LS instrument's broad spectral resolution element (~250 km/s

Changes in nitrogen functional genes and microbial populations in soil profiles of a peatland under different burning regimes

Microbes in peatlands provide key ecosystem services and are essential for their role in biogeochemical cycling. Prescribed burning is a common aspect of peatland management but the practice has been criticized for being ecologically damaging due to its effect on the biological, chemical and physical properties of the soil. It is poorly understood how burning affects soil N cycling and previous studies have focused predominantly on the topsoil whilst giving less attention to changes with soil depth. This study investigated the changes of microbial abundance (bacterial 16S rRNA and fungal 18S rRNA) and the abundance of N-cycle functional genes involved in archaeal and bacterial ammonia oxidation (amoA-AOA and amoA-AOB), denitrification (nirK and nirS), N fixation (nifH) and organic N decomposition (chiA) in soil profiles across three burn treatments on a managed peatland landscape (a ‘non-burn’ since 1954 control, 20 years burn interval, and 10 years burn interval). Our results indicate the abundance of bacterial 16S rRNA and fungal 18 s rRNA was affected by burn treatment, soil depth and their interaction and were greater in the non-burn control plots. The abundances of amoA-AOA, amoA-AOB, and nifH were significantly higher in the topsoil of the non-burn control plots while the abundance of nirK was higher in plots subject to short rotation and long rotation burn regimes but also decreased significantly with soil depth. The abundance of nirS was not affected by burn treatment or soil depth. ChiA abundance was affected by burn treatment, soil depth and their interaction. N-cycle functional gene abundance responded differently to environmental factors associated with prescribed burning and varied with soil depth. These findings suggest that the practice of burning affects microbial N turnover potential and provides an important insight into the soil N-cycling potential of peatlands under different burning regimes