Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction

A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques

Researching the lives of disabled children and young people

Why a Special Issue of Children & Society dedicated to disabled children and young people? The simple answer to that question is ‘because disabled children are children first and foremost’. The vast majority of disabled children and young people in the western world live at home with their families, most attending mainstream schools, and disabled children and young people worldwide have rights to inclusion and equal treatment enshrined in national legislation and international conventions. Yet they often remain left out – from generic children’s research, from policy-making about children’s services and, in their everyday lives, from inclusion in friendship groups and social and sporting activities

Sentiment analysis of comments in social media

Social media platforms are witnessing a significant growth in both size and purpose. One specific aspect of social media platforms is sentiment analysis, by which insights into the emotions and feelings of a person can be inferred from their posted text. Research related to sentiment analysis is acquiring substantial interest as it is a promising filed that can improve user experience and provide countless personalized services. Twitter is one of the most popular social media platforms, it has users from different regions with a variety of cultures and languages. It can thus provide valuable information for a diverse and large amount of data to be used to improve decision making. In this paper, the sentiment orientation of the textual features and emoji-based components is studied targeting “Tweets” and comments posted in Arabic on Twitter, during the 2018 world cup event. This study also measures the significance of analyzing texts including or excluding emojis. The data is obtained from thousands of extracted tweets, to find the results of sentiment analysis for texts and emojis separately. Results show that emojis support the sentiment orientation of the texts and that texts or emojis cannot separately provide reliable information as they complement each other to give the intended meaning

Morphology and distribution of the spinner dolphin, <i>Stenella longirostris</i>, rough-toothed dolphin, <i>Stenella bredanensis</i> and melon-headed whale, <i>Peponocephala electra</i>, from waters off the Sultanate of Oman

The morphology of three tropical delphinids from the Sultanate of Oman and their occurrence in the Arabian Sea are presented. Body lengths of four physically mature spinner dolphins (three males) ranged from 154-178.3cm (median 164.5cm), i.e. smaller than any known stock of spinner dolphins, except the dwarf forms from Thailand and Australia. Skulls of Oman spinner dolphins (n=10) were practically indistinguishable from those of eastern spinner dolphins (Stenella longirostris orientalis) from the eastern tropical Pacific, but were considerably smaller than skulls of populations of pantropical (Stenella longirostris longirostris) and Central American spinner dolphins (Stenella longirostris centroamericana). Two colour morphs (CM) were observed. The most common (CM1) has the typical tripartite pattern of the pantropical spinner dolphin. A small morph (CM2), so far seen mostly off Muscat, is characterised by a dark dorsal overlay obscuring most of the tripartite pattern and by a pinkish or white ventral field and supragenital patch. Two skulls were linked to a CM1 colour morph, the others were undetermined. It is concluded that Oman spinner dolphins should be treated as a discrete population, morphologically distinct from all known spinner dolphin subspecies. Confirmed coastal range states off the Arabian Peninsula include the United Arab Emirates, the Sultanate of Oman, Yemen, Somalia, Djibouti, Saudi Arabia, Sudan and Egypt. The taxonomic position of the two damaged dolphin calvariae from Oman has been the issue of much debate. This paper discusses the cranial characteristics that allow positive identification as rough-toothed dolphin (Steno bredanensis) and melon-headed whale (Peponocephala electra) respectively. The calvariae represent the first confirmed specimen records of these dolphin species for the Arabian Sea sensu lato

Cell-permeable lanthanide-platinum(iv) anti-cancer prodrugs

Platinum compounds are a vital part of our anti-cancer arsenal, and determining the location and speciation of platinum compounds is crucial. We have synthesised a lanthanide complex bearing a salicylic group (Ln = Gd, Eu) which demonstrates excellent cellular accumulation and minimal cytotoxicity. Derivatisation enabled access to bimetallic lanthanide–platinum(II) and lanthanide–platinum(IV) complexes. Luminescence from the europium–platinum(IV) system was quenched, and reduction to platinum(II) with ascorbic acid resulted in a “switch-on” luminescence enhancement. We used diffusion-based 1H NMR spectroscopic methods to quantify cellular accumulation. The gadolinium–platinum(II) and gadolinium–platinum(IV) complexes demonstrated appreciable cytotoxicity. A longer delay following incubation before cytotoxicity was observed for the gadolinium–platinum(IV) compared to the gadolinium–platinum(II) complex. Functionalisation with octanoate ligands resulted in enhanced cellular accumulation and an even greater latency in cytotoxicity

The liminality of trajectory shifts in institutional entrepreneurship

In this paper, we develop a process model of trajectory shifts in institutional entrepreneurship. We focus on the liminal periods experienced by institutional entrepreneurs when they, unlike the rest of the organization, recognize limits in the present and seek to shift a familiar past into an unfamiliar and uncertain future. Such periods involve a situation where the new possible future, not yet fully formed, exists side-by-side with established innovation trajectories. Trajectory shifts are moments of truth for institutional entrepreneurs, but little is known about the underlying mechanisms of how entrepreneurs reflectively deal with liminality to conceive and bring forth new innovation trajectories. Our in-depth case study research at CarCorp traces three such mechanisms (reflective dissension, imaginative projection, and eliminatory exploration) and builds the basis for understanding the liminality of trajectory shifts. The paper offers theoretical implications for the institutional entrepreneurship literature