Predictors of atherosclerotic lesions of limb arteries according to cardioangiological screening of the adult population

Aim. To study the predictors of atherosclerotic lesions of arteries identified through a multi-channel volume sphygmography (MCVS). Material and methods. Simultaneous survey of 441 rural residents over 40 years old was performed. Synchronous registration of blood pressure (BP) on four limbs using MCVS was fulfilled, and differences in systolic BP between arms (ΔSBParm) and legs (ΔSBPleg) were calculated. Ankle-brachial index (ABI) was also evaluated. |ΔSBParm|≥15 mm Hg or |δSBPleg|≥15 mm Hg or ABI=0.9 were considered as the markers of atherosclerotic arterial disease. Results. A significant asymmetry of SBP (≥15 mmHg) was found in 7.7% [95% confidence interval (CI) 5.5-10.6%] of patients in the upper limbs and in 6.8% (95 % CI 4.8-9.6%) of patients in the lower extremities. The relative risk of asymmetry of SBP (≥15 mm Hg) in the upper limbs increased in hypertension and obesity, and in the lower limbs - in men and diabetes. Various quantitative risk factors of the onset and progression of atherosclerosis (age, body mass index, waist circumference, blood glucose, BP level) had a positive correlation with the level of asymmetry of SBP on the limbs. Using MCVS and the appropriate combinations of features (SBP asymmetry or ABI≤0.9) allowed us at the stage of screening to find out blood flow disturbances in the arteries of the extremities in 14.7% (95% CI 11.7-18.4%) of patients. This detection frequency was significantly higher than that when using only ABI. Conclusion. Identification of significant SBP asymmetry (≥15 mm Hg) in the limbs may improve the diagnosis of atherosclerotic arterial disease at the stage of screening

Predictors of atherosclerotic lesions of limb arteries according to cardioangiological screening of the adult population

Aim. To study the predictors of atherosclerotic lesions of arteries identified through a multi-channel volume sphygmography (MCVS). Material and methods. Simultaneous survey of 441 rural residents over 40 years old was performed. Synchronous registration of blood pressure (BP) on four limbs using MCVS was fulfilled, and differences in systolic BP between arms (ΔSBParm) and legs (ΔSBPleg) were calculated. Ankle-brachial index (ABI) was also evaluated. |ΔSBParm|≥15 mm Hg or |δSBPleg|≥15 mm Hg or ABI=0.9 were considered as the markers of atherosclerotic arterial disease. Results. A significant asymmetry of SBP (≥15 mmHg) was found in 7.7% [95% confidence interval (CI) 5.5-10.6%] of patients in the upper limbs and in 6.8% (95 % CI 4.8-9.6%) of patients in the lower extremities. The relative risk of asymmetry of SBP (≥15 mm Hg) in the upper limbs increased in hypertension and obesity, and in the lower limbs - in men and diabetes. Various quantitative risk factors of the onset and progression of atherosclerosis (age, body mass index, waist circumference, blood glucose, BP level) had a positive correlation with the level of asymmetry of SBP on the limbs. Using MCVS and the appropriate combinations of features (SBP asymmetry or ABI≤0.9) allowed us at the stage of screening to find out blood flow disturbances in the arteries of the extremities in 14.7% (95% CI 11.7-18.4%) of patients. This detection frequency was significantly higher than that when using only ABI. Conclusion. Identification of significant SBP asymmetry (≥15 mm Hg) in the limbs may improve the diagnosis of atherosclerotic arterial disease at the stage of screening

Multi-channel volume sphygmography in cardioangiological screening of the adult population

Aim. To study the possibilities of using multi-channel volume sphygmography (MCVS) in prophylactic medical examination of the population. Material and methods. Simultaneous examination of 522 individuals older than 18 years was performed. Along with standard procedures provided by the prophylactic medical examination program synchronous registration of blood pressure (BP) on four extremities by MCVS was performed. At that a difference in systolic BP between arms (Delta SBParm) and legs (Delta SBPleg) and ankle-brachial index (ABI) were automatically calculated. Values of vertical bar Delta SBParm vertical bar or vertical bar Delta SBPleg vertical bar >= 15 mm Hg or ABI = 40 years old were found in 14.7% of the cases (95% confidence interval [CI] 11.7-18.4). Relative risks of atherosclerotic lesions in arteries increase 1.71-fold (95% CI 1.06-2.74) in arterial hypertension, 1.70-fold (95% CI 1.08-2.68) - in obesity, 1.91 fold (95% CI 1.17-3.12) - in diabetes, as well as with the increasing levels of cardiovascular risk. In patients with ischemic heart disease and a history of cerebral stroke MCVS can detect signs of multifocal atherosclerosis in 21% (95% CI 14-32) and 22% (95% CI 9-46) of the cases, respectively. Conclusion. MCVS with the determination of Delta SBParm, Delta SBPleg and ABI may be regarded as the basis for low-cost and efficient system of cardioangiological screening

Multi-channel volume sphygmography in cardioangiological screening of the adult population

Aim. To study the possibilities of using multi-channel volume sphygmography (MCVS) in prophylactic medical examination of the population. Material and methods. Simultaneous examination of 522 individuals older than 18 years was performed. Along with standard procedures provided by the prophylactic medical examination program synchronous registration of blood pressure (BP) on four extremities by MCVS was performed. At that a difference in systolic BP between arms (Delta SBParm) and legs (Delta SBPleg) and ankle-brachial index (ABI) were automatically calculated. Values of vertical bar Delta SBParm vertical bar or vertical bar Delta SBPleg vertical bar >= 15 mm Hg or ABI = 40 years old were found in 14.7% of the cases (95% confidence interval [CI] 11.7-18.4). Relative risks of atherosclerotic lesions in arteries increase 1.71-fold (95% CI 1.06-2.74) in arterial hypertension, 1.70-fold (95% CI 1.08-2.68) - in obesity, 1.91 fold (95% CI 1.17-3.12) - in diabetes, as well as with the increasing levels of cardiovascular risk. In patients with ischemic heart disease and a history of cerebral stroke MCVS can detect signs of multifocal atherosclerosis in 21% (95% CI 14-32) and 22% (95% CI 9-46) of the cases, respectively. Conclusion. MCVS with the determination of Delta SBParm, Delta SBPleg and ABI may be regarded as the basis for low-cost and efficient system of cardioangiological screening

Hypolipidemic effect and leskol tolerance in hypertensive patients with hypercholesterolemia: Results of multicenter trial

Hypertensive patients with hyperlipidemia are at high risk to develop coronary heart disease (CHD). Chemotherapeutic correction of hyperlipidemia seems most reliable modality to prevent CHD. Hypolipidemic effect and tolerance of leskol (fluvastatin) in dietotherapy-resistant hypercholesterolemia were studied in 74 patients with essential hypertension treated with hypotensive drugs. The patients were included in a multicenter trial. A 12-week course reduced total cholesterol level under 6.2 mmol/l in 59% of the patients, under 5.2 mmol/l in 29% of them. LDLP cholesterol lowered to 3.5% in 34% of the patients. Mean apo B diminished by 23%. There was a 27% decrease in the proportion of atherogenic fraction apo B to antiatherogenic fraction of transport proteins apo A-I. Leskol is well tolerated and effective against hypercholesterolemia, it is safe in relation to side effects and blood biochemistry

HYPOLIPIDEMIC EFFECT AND LESKOL TOLERANCE IN HYPERTENSIVE PATIENTS WITH HYPERCHOLESTEROLEMIA - RESULTS OF MULTICENTER TRIAL

Hypertensive patients with hyperlipidemia are at high risk to develop coronary heart disease (CHD). Chemotherapeutic correction of hyperlipidemia seems most reliable modality to prevent CHD. Hypolipidemic effect and tolerance of leskol (fluvastatin) in dietotherapy-resistant hypercholesterolemia were studied in 74 patients with essential hypertension treated with hypotensive drugs. The patients were included in a multicenter trial. A 12-week course reduced total cholesterol level under 6.2 mmol/l in 59% of the patients, under 5.2 mmol/l in 29% of them. LDLP cholesterol lowered to 3.5% in 34% of the patients. Mean apo B diminished by 23%. There was a 27% decrease in the proportion of atherogenic fraction apo B to antiatherogenic fraction to transport proteins apo A-I. Leskol is well tolerated and effective against hypercholesterolemia, it is safe in relation to side effects and blood biochemistry

HYPOLIPIDEMIC EFFECT AND LESKOL TOLERANCE IN HYPERTENSIVE PATIENTS WITH HYPERCHOLESTEROLEMIA - RESULTS OF MULTICENTER TRIAL

Hypertensive patients with hyperlipidemia are at high risk to develop coronary heart disease (CHD). Chemotherapeutic correction of hyperlipidemia seems most reliable modality to prevent CHD. Hypolipidemic effect and tolerance of leskol (fluvastatin) in dietotherapy-resistant hypercholesterolemia were studied in 74 patients with essential hypertension treated with hypotensive drugs. The patients were included in a multicenter trial. A 12-week course reduced total cholesterol level under 6.2 mmol/l in 59% of the patients, under 5.2 mmol/l in 29% of them. LDLP cholesterol lowered to 3.5% in 34% of the patients. Mean apo B diminished by 23%. There was a 27% decrease in the proportion of atherogenic fraction apo B to antiatherogenic fraction to transport proteins apo A-I. Leskol is well tolerated and effective against hypercholesterolemia, it is safe in relation to side effects and blood biochemistry

Hypolipidemic effect and leskol tolerance in hypertensive patients with hypercholesterolemia: Results of multicenter trial

Hypertensive patients with hyperlipidemia are at high risk to develop coronary heart disease (CHD). Chemotherapeutic correction of hyperlipidemia seems most reliable modality to prevent CHD. Hypolipidemic effect and tolerance of leskol (fluvastatin) in dietotherapy-resistant hypercholesterolemia were studied in 74 patients with essential hypertension treated with hypotensive drugs. The patients were included in a multicenter trial. A 12-week course reduced total cholesterol level under 6.2 mmol/l in 59% of the patients, under 5.2 mmol/l in 29% of them. LDLP cholesterol lowered to 3.5% in 34% of the patients. Mean apo B diminished by 23%. There was a 27% decrease in the proportion of atherogenic fraction apo B to antiatherogenic fraction of transport proteins apo A-I. Leskol is well tolerated and effective against hypercholesterolemia, it is safe in relation to side effects and blood biochemistry

Клинические рекомендации по семейной гиперхолестеринемии

These guidelines represent all current aspects of etiology diagnosis, and treatment of the clinical and statistical group of familial hypercholesterolemia in both adults and children in accordance with the requirements of the Ministry of Health of Russia.Данные клинические рекомендации представляют все современные аспекты этиологии, диагностики, лечения семейной гиперхолестеринемии как у взрослых, так и у детей. Рекомендации подготовлены для размещения в соответствующем рубрикаторе клинических рекомендаций Минздрава России в сети Интернет по адресу http://cr.rosmincylrav.ml