10 research outputs found
Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells
Relapsed cervicomediastinal lymph node carcinoma with an unknown primary site treated with TS-1 alone: a case report
Adrenocortical oncocytoma: Case report with immunocytochemical and ultrastructural study
Surgery After Downstaging of Unresectable Hepatic Tumors With Intra-Arterial Chemotherapy
Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects
International audienceParacetamol and NSAIDs, in particular acetylsalicylic acid (aspirin) and ibuprofen, are among the most used and environmentally released pharmaceutical drugs. The differences in international trends in the sale and consumption of mild analgesics reflect differences in marketing, governmental policies, habits, accessibility, disease patterns and the age distribution of each population. Biomonitoring indicates ubiquitous and high human exposure to paracetamol and to salicylic acid, which is the main metabolite of acetylsalicylic acid. Furthermore, evidence suggests that analgesics can have endocrine disruptive properties capable of altering animal and human reproductive function from fetal life to adulthood in both sexes. Medical and public awareness about these health concerns should be increased, particularly among pregnant women