7 research outputs found
Predicting Peptide Binding Affinities to MHC Molecules Using a Modified Semi-Empirical Scoring Function
- Author
- A Solache
- A van Elsas
- AI Webb
- AJ Bordner
- AJ Bordner
- AJ Schiewe
- B Honig
- B Serafini
- B-H Mevik
- BE Willcox
- C Lundegaard
- C Lundegaard
- C Texier
- CC Wilson
- CK Hattotuwagama
- D Rognan
- D Sitkoff
- DA Hafler
- DA Hafler
- DR Madden
- Eugene A. Permyakov
- FC Westall
- G Zeng
- GB Stewart-Jones
- GF Gao
- GG Krivov
- H McSparron
- HLE Lang
- HM Berman
- I Dimitrov
- I Hoof
- IW Davis
- J Hennecke
- J Hennecke
- J Sidney
- JL Chen
- JM Word
- Jonathan W. Arthur
- KJ Smith
- KW Wucherpfennig
- M Bouvier
- M Eldridge
- M Hahn
- M Nielsen
- M Nielsen
- M Sami
- MC Levin
- MJ Blythe
- N Kumar
- OY Borbulevych
- OY Borbulevych
- P Wang
- PHN Celie
- S Aldulaijan
- S Gras
- S Lata
- SM Dunn
- SO Dionne
- W Rocchia
- Webber W. P. Liao
- WW Liao
- Y Altuvia
- Z Li
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The Major Histocompatibility Complex (MHC) plays an important role in the human immune system. The MHC is involved in the antigen presentation system assisting T cells to identify foreign or pathogenic proteins. However, an MHC molecule binding a self-peptide may incorrectly trigger an immune response and cause an autoimmune disease, such as multiple sclerosis. Understanding the molecular mechanism of this process will greatly assist in determining the aetiology of various diseases and in the design of effective drugs. In the present study, we have used the Fresno semi-empirical scoring function and modify the approach to the prediction of peptide-MHC binding by using open-source and public domain software. We apply the method to HLA class II alleles DR15, DR1, and DR4, and the HLA class I allele HLA A2. Our analysis shows that using a large set of binding data and multiple crystal structures improves the predictive capability of the method. The performance of the method is also shown to be correlated to the structural similarity of the crystal structures used. We have exposed some of the obstacles faced by structure-based prediction methods and proposed possible solutions to those obstacles. It is envisaged that these obstacles need to be addressed before the performance of structure-based methods can be on par with the sequence-based methods
Validation-verification of a highly effective, practical human testicular tissue in vitro culture-cryopreservation procedure aimed to optimize pre-freeze and post-thaw motility
- Author
- A Kamal
- A. Spitz
- AJ Wyrobek
- C. Rothman
- D Dozortsev
- D Levran
- E Beebe
- E Crabbé
- E Crabbé
- F-J Huang
- G Palermo
- G Verheyen
- G Verheyen
- GS Prins
- H Habermann
- H Sallam
- I Craft
- I Tasdemir
- IK Glasgow
- J Liu
- JA Allan
- JK Critser
- LH Dalzell
- M Mahedevan
- M. C. Schiewe
- MC Schiewe
- ME Thompson-Cree
- MR Virro
- N Slepko
- NM Oliveira de
- P Devroey
- P Devroey
- P. E. Werthman
- PN Schlegel
- R Schoysman
- R. E. Anderson
- S Emiliani
- S Emiliani
- S. I. Zeitlin
- SJ Silber
- SJ Silber
- T Angelopoulos
- V Mangoli
- V Vernaeve
- VW Aoki
- W Kupker
- WR Edirisinghe
- Y Hu
- Y-S Park
- ZP Nagy
- ZP Nagy
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Modified carbon-containing electrodes in stripping voltammetry of metals. Part II. Composite and microelectrodes
- Author
- A Chatterjee
- A Domenech-Carbo
- A Doménech-Carbό
- A Doménech-Carbό
- A Goodwin
- A Manivannan
- A Manivannan
- A Mylonakis
- A Walcarius
- A Zeng
- A Zeng
- AA Bumber
- AI Kamenev
- AI Kamenev
- AI Kаmеnеv
- AI Kаmеnеv
- AI Каmеnеv
- AJ Saterlay
- AL Colley
- AM Bond
- AM Zimer
- AN Doronin
- AS Baranski
- BJ Feldman
- C Babyak
- C Faller
- C Faller
- C Gouveia-Caridade
- C Parat
- C Prado
- CE Banks
- CE Banks
- CE Banks
- CE Banks
- CG Neuhold
- CG Zoski
- CH Goeting
- CM Welch
- CMA Brett
- CMVB Almeida
- D Demetriades
- D Desmond
- D Dragoe
- D Hernandez-Santos
- D O’Hare
- DA Fiedler
- DDL Chung
- DE Tallman
- E Desimoni
- E Katz
- EA Hutton
- EA McGaw
- EA Viltchinskaia
- EA Viltchinskaia
- EA Zakharova
- EA Zakharova
- EA Zakharovа
- EE Теkutskаia
- EE Теkutskаia
- F Albertus
- F Scholz
- F Scholz
- F Wantz
- FM Matysik
- G Gun
- G Liu
- G Sanna
- G Zhao
- GG Wildgoose
- GG Мuntianu
- GG Мuntianu
- GG Мuntianu
- GG Мuntianu
- GG Мuntianu
- GK Budnikov
- GN Popkovа
- GS Reeder
- H Emons
- H Kahlert
- H Zejli
- I Ciglenečki
- I Palchetti
- I Palchetti
- IP Viter
- IR Bаtаlоvа
- J Kruusma
- J Kruusma
- J Kruusma
- J Labuda
- J Labudа
- J Liu
- J Schiewe
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J Wang
- J-J Sun
- JM Zen
- JP Hart
- JY Choi
- K Seo
- K Štulik
- KC Honeychurch
- KC Honeychurch
- KC Honeychurch
- KC Honeychurch
- KC Honeychurch
- Kh Brainina
- Kh Brainina
- Kh Brainina
- Khiena Z. Brainina
- KhZ Brainina
- KHZ Brainina
- KhZ Brainina
- KhZ Brainina
- KhZ Brainina
- KhZ Brainina
- KZ Brainina
- L Lin
- L Mooring
- L Rabinovich
- LA Khustenkо
- LA Khustenkо
- LD Svintsovа
- LE Steninа
- LI Scvortsova
- LK Shpigun
- LK Shpigun
- LS Nadezhinа
- LS Nadezhinа
- M Huang
- M Jasinski
- M Kopanica
- M Korolczuk
- M Opallo
- M Wojciechowski
- MA Baldo
- MA Baldo
- MA Ghanem
- MC Weston
- Mikhail V. Fyodorov
- MM Cordero-Rando
- MR Khan
- MR Majidi
- MV Tsymbal
- N Dijk
- N Spano
- N Stojko
- NA Kоlpаkоvа
- NA Kоlpаkоvа
- NA Malakhova
- NA Malakhova
- NA Malakhova
- NA Malakhova
- Natalya A. Malakhova
- Natalya Yu. Stozhko
- NV Тоbоlkinа
- NV Тоbоlkinа
- NYu Stojko
- NYu Stojko
- NYu Stojko
- NYu Stojko
- NYu Stojko
- NYu Stojko
- NYu Stojko
- NYU Stozhko
- NYu Stozhko
- O Bagel
- O Renedo
- O Renedo
- OE Tall
- OG Filichkinа
- OG Filichkinа
- OMS Filipe
- P Akhtar
- P Sonthalia
- P Ugo
- PN Bartlett
- Q Yin
- R Feeney
- R Pauliukaite
- R Ye
- R Ye
- RI Stefan
- RM Barbosa
- RN Маtakovа
- RT Kachoosangi
- RU Vakhobova
- RYu Bek
- RYu Bek
- S Carregalo
- S Daniele
- S Ramirez-Garcia
- S Zhang
- SB Khoo
- SB Khoo
- SC Petrovic
- SEI Roustom
- SM Silva
- SM Silva
- T Grygar
- T Navrátil
- TG Tsupko
- TZ Liu
- V Saez
- VA Таrаsоvа
- VN Kirushov
- VN Kirushov
- VN Кirushov
- VN Кirushov
- VN Маystrenkо
- W Yantasee
- W Yantasee
- Y Einaga
- Y Jin
- Y Maeda
- Y Shin
- Y Song
- Y Song
- YC Tsai
- YI Tur’yan
- YuB Klеtеnik
- Z Hu
- Z Ji
- Z Liu
- Z Lukaszewski
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Relating Biochemical Responses to “Higher Order” Effects
- Author
- AB Okey
- AJ Edwards
- BL Bayne
- BP Dunn
- CN Statham
- J Widdows
- J Widdows
- J Widdows
- JE Stein
- JE Stein
- JE Stein
- JJ Stegeman
- JJ Stegeman
- JJ Stegeman
- JJ Stegeman
- JS Gray
- KM Kleinow
- KR Munkittrick
- L Förlin
- L Förlin
- L Förlin
- ME McMaster
- MH Schiewe
- MJ Graham
- MJ Melancon
- MJ Vodicnik
- MR Waterman
- RB Spies
- RB Spies
- RM Warwick
- T Hansson
- TK Collier
- U Varanasi
- U Varanasi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Nonlinear Impedances (Higher Harmonics)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Quality Management Issues in the Assisted Reproduction Laboratory
- Author
- Abramczuk JW
- Ackerman SB
- Aggarwal BB
- Al-Shawaf T
- Alexandre HL
- Ali J
- Ali J
- Alliston CW
- Alliston CW
- Almeida PA
- Andersen SR
- Anderson AR
- Arny M
- Avery B
- Awda BJ
- Awonuga A
- Balaban B
- Ball GD
- Barlow P
- Barnett DK
- Barrett CB
- Batt PA
- Battaglia DE
- Bavister B
- Bavister BD
- Bavister BD
- Bavister BD
- Bean CJ
- Bedford JM
- Bedford JM
- Bernard RS
- Bertheussen K
- Bertheussen KH
- Beseth L
- Bielanski A
- Bielanski A
- Bielanski A
- Bielfeld P
- Blackshaw AW
- Blandau R
- Blandau RJ
- Bols PEJ
- Bols PEJ
- Bondioli KR
- BonDurant RH
- Boone WR
- Boone WR
- Boone WR
- Boone WR
- Boone WR
- Boone WR
- Boone WR
- Borque C
- Bradley MO
- Brazil CK
- Brinster RL
- Brinster RL
- Brison DR
- Broussard JR
- Bungartz L
- Burfening PJ
- Burke LM
- Burkman LJ
- Byatt-Smith JG
- Byers SL
- Canesco RS
- Carney EW
- Caro CM
- Cartmill D
- Catt JW
- Chang MC
- Clarke RN
- Clements S
- Cohen J
- Cohen J
- Cohen J
- Cohen J
- Cohen J
- Comhaire F
- Condon-Mahony M
- Cooke S
- Cooper TG
- Coroleu B
- Cragle RG
- Critchlow JD
- Cummins JM
- Cunningham KJ
- Cutting RC
- Dale B
- Dandekar PV
- Daniel JC
- Davidson A
- Davidson A
- de Castro e Paula LA
- De Placido G
- De Rosa M
- De Rosa M
- Dinnie H
- Driancourt MA
- Duarte de Oliveira AT
- Dubin NH
- Dudkiewicz A
- Dumesic DA
- Dumoulin JCM
- Edwards LJ
- Edwards RG
- Eibs H-G
- Elhassan YM
- Elliott DS
- Emmens CW
- Eng LA
- Esterhuizen AD
- Fischer B
- Fischer B
- FitzGerald L
- Fleetham JA
- Fleming TP
- Flick DL
- Foote RH
- Fowler IM
- Francis MM
- Franken DR
- Frankfurter D
- Froman DP
- Fry RC
- Fujita T
- Fujiwara M
- Fukuda A
- Gabler FR
- Gaddum-Rosse P
- Gardner DK
- Gardner DK
- Gardner DK
- Gardner DK
- Gardner DK
- Gardner DK
- Gardner DK
- Geisthövel F
- George MA
- Gerrity M
- Ghazzawi IM
- Gianaroli L
- Gianfortoni JG
- Gibbons JR
- Gigli I
- Gil MA
- Gilligan AV
- Ginsburg KA
- Goldenberg RL
- Gonen Y
- Gong Y
- Goovaerts IGF
- Gorrill MJ
- Goudas VT
- Gould M
- Gouveia N
- Graves JE
- Graves WM
- Greenlee AR
- Grunert GM
- Hadek R
- Haines CJ
- Hall BV
- Hall J
- Han H-D
- Harlow GM
- Harrison KL
- Harvey AJ
- Heape W
- Hearns-Stokes RM
- Hegele-Hartung C
- Herlong JL
- Herr CM
- Herr CM
- Hershlag A
- Hershlag A
- Higdon HL
- Higdon HL
- Hill D
- Hill DL
- Hirao Y
- Hirao Y
- Hockberger PE
- Holyoak GR
- Holyoak GR
- Houghton FD
- Hughes MA
- HyClone Laboratories
- HyClone Laboratories
- HyClone Laboratories
- Hyllner SJ
- Iemmolo M
- Imade GE
- Iwamatsu T
- Jackson KV
- Jackson KV
- Jequier AM
- Jinno M
- John DP
- Johnson DE
- Johnson JE
- Johnson JE
- Johnson JE
- Johnson JE
- Johnson JE
- Johnson JE
- Johnson JE
- Johnson JE
- Jones HW
- Kao YK
- Karagenc L
- Karande V
- Karande VC
- Kasai M
- Kea B
- Keck C
- Khabani A
- King GB
- Kishi J
- Kito S
- Knasiak-Paluch D
- Knezevich KM
- Kruger TF
- Kruger TF
- Kruip TAM
- Kutteh WH
- Lambert RD
- Lane M
- Lane M
- Lane M
- Lane M
- Langley MT
- Lardy HA
- Larson JM
- Lavy G
- Lawrence C
- Ledbeter DH
- Lee BE
- Leeton J
- Legro RS
- Leibo SP
- Lenz RW
- Leung PCS
- Li H
- Li J
- Li M
- Lichtenfels AJFC
- Lim JM
- Limone LE
- Lin CA
- Lindner GM
- Liu Z
- Lopata A
- Lopata A
- Lopes AS
- Loutradis D
- Lu SS
- Maffeo S
- Maffeo S
- Magli MC
- Mahadevan MM
- Mahmoud AM
- Maisonet M
- Malyala P
- Mansour R
- Martin AH
- Mastroianni L
- Mather J
- Matilsky MB
- Mayer JF
- Mayer JF
- Mayer JF
- Mazzola PG
- McDonald JA
- McDowell JS
- McIlveen M
- McKiernan SH
- McLellan ST
- McLimans WF
- Mehta RH
- Meriano J
- Merton JS
- Mettler L
- Miller JW
- Miller KF
- Miyamoto H
- Mohallem SV
- Moinipanah R
- Moor RM
- Moretti E
- Mortimer D
- Mubarak AAS
- Muechler EK
- Murray AS
- Nagao Y
- Nagata Y
- Naglee DL
- Nagy A
- Nakayama T
- Naz RK
- Nehchiri F
- Niwa K
- Noda Y
- O'Fallon JV
- O'Neill C
- O'Neill C
- Ogawa T
- Ogawa T
- Okano A
- Olar TT
- Olds D
- Orhon E
- Otsuki J
- Otsuki J
- Ottosen LDM
- Ozawa M
- Pacey AA
- Paluch D
- Papageorgiou TC
- Paria BC
- Parinaud J
- Parkening TA
- Parkening TA
- Parkening TA
- Parmegiani L
- Pavlok A
- Pennycuik PR
- Pereira LAA
- Phillips KP
- Pickering SJ
- Plante L
- Po HN
- Pocar P
- Pocar P
- Pool SH
- Pool TB
- Pope CE
- Pope CS
- Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology
- Prien SD
- Provo MB
- Putney DJ
- Quinn P
- Quinn P
- Quinn P
- Quinn P
- Quinn P
- Quinn P
- Rauth AM
- Ray BD
- Reed ML
- Revel A
- Rhodes TL
- Rhodes TL
- Richardson ME
- Richardson ME
- Rieger D
- Rinaudo PF
- Rinehart JS
- Rivera RM
- Robertson JL
- Rocha e Silva IR
- Rogers JF
- Roseboom TJ
- Rosenlund B
- Ross RN
- Rubes J
- Saeki K
- Sakkas D
- Salahuddin S
- Sallam HN
- Sallam HN
- Sapatino BV
- Sauer MV
- Schenk SL
- Schiewe MC
- Schiewe MC
- Schneider U
- Schumacher A
- Schumacher A
- Schwimer SR
- Scott CA
- Scott LF
- Scott RT
- Scott RT
- Seaman EK
- Seli E
- Seli E
- Sertich PL
- Shi DS
- Shimada M
- Shimonovitz S
- Shiran E
- Slott V
- Snyman E
- Sokoloski JE
- Spandorfer SD
- Spyropoulou I
- Squirrell JM
- Stokes PJ
- Stránská E
- Suzuki S
- Svalander PC
- Svalander PC
- Swain JE
- Takahashi M
- Tanphaichitr N
- Tervit HR
- Thompson JG
- Thompson JGE
- Thouas GA
- Trounson AO
- Trounson AO
- Ulberg LC
- Ulberg LC
- Umaoka Y
- Urman B
- Vajta G
- van de Pas MMC
- Van den Abbeel E
- Van den Bergh M
- Van der Auwera I
- Van Weering HGI
- Veeck LL
- Vishwakarma P
- Visser DS
- von Wyl S
- Wagner-Coughlin CM
- Wallace GA
- Wamil BD
- Wang W-H
- Wataha JC
- Waterstone J
- Waymouth C
- Weiss TJ
- Wells EF
- Whitten WK
- Whitten WK
- Whitten WK
- Whittingham DG
- Wiley LM
- Winston NJ
- Wisanto A
- Wood EG
- Worrilow KC
- Worrilow KC
- Wright RW
- Wright RW
- Wright RW
- Wright RW
- Yamauchi Y
- Yeung QSY
- Zabojszcz W
- Zakari AY
- Zaninovic N
- Zervins A
- Zhao Y
- Zusman I
- Álvarez C
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
The Famlily Vibrionaceae
- Author
- A Böck
- A Camilli
- A Can-Gomez
- A Coelho
- A Coelho
- A Dalsgaard
- A Dalsgaard
- A Dalsgaard
- A Dalsgaard
- A Dalsgaard
- A DePaola
- A DePaola
- A DePaola
- A DePaola
- A Fabris
- A Hjelm Mette
- A Huq
- A Hülsmann
- A Lacoste
- A Lozano-Leon
- A Luna-Gonzalez
- A Molina-Aja
- A Mukherji
- A Naka
- A Petroni
- A Roque
- A Roque
- A Roque
- A Sunaryanto
- A Thyssen
- A Ventosa
- A Vezzi
- A Zitzer
- AA Adzhieva
- AB Khaitovich
- AC Vicente
- AC Wright
- AC Wright
- AC Wright
- AE Toranzo
- AE Toranzo
- AF Andersson
- AF Auch
- AJ Driessen
- AJ Haugo
- AJ Silva
- AK Mukhopadhyay
- AL Furniss
- AM Carnahan
- AS Kreger
- AS Schmidt
- ASS Hameed
- ASS Hameed
- B Allam
- B Austin
- B Austin
- B Austin
- B Chang
- B Fouz
- B Fouz
- B Fouz
- B Gomez-Gil
- B Gomez-Gil
- B Gomez-Gil
- B Gomez-Gil
- B Gomez-Gil
- B Gomez-Gil
- B Hazes
- B Hjeltnes
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- B Hochhut
- B Kloareg
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- C Amaro
- C Amaro
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