10 research outputs found
Activin A Promotes Hematopoietic Fated Mesoderm Development Through Upregulation of Brachyury in Human Embryonic Stem Cells
POU-V factors antagonize maternal VegT activity and ÎČ-Catenin signaling in Xenopus embryos
VegT and ÎČ-Catenin are key players in the hierarchy of factors that are required for induction and patterning of mesendoderm in Xenopus embryogenesis. By descending the genetic cascades, cells lose their pluripotent status and are determined to differentiate into distinct tissues. Mammalian Oct-3/4, a POU factor of subclass V (POU-V), is required for the maintenance of pluripotency of embryonic stem cells. However, its molecular function within the early embryo is yet poorly understood. We here show that the two maternal Xenopus POU-V factors, Oct-60 and Oct-25, inhibit transcription of genes activated by VegT and ÎČ-Catenin. Maternal POU-V factors and maternal VegT show an opposite distribution along the animal/vegetal axis. Oct-25, VegT and Tcf3 interact with each other and form repression complexes on promoters of VegT and ÎČ-Catenin target genes. We suggest that POU-V factors antagonize primary inducers to allow germ layer specification in a temporally and spatially coordinated manner
Utx Is Required for Proper Induction of Ectoderm and Mesoderm during Differentiation of Embryonic Stem Cells
Phosphate uptake kinetics and tissue-specific transporter expression profiles in poplar (PopulusâĂâcanescens) at different phosphorus availabilities
Measurement of the spin structure of the deuteron in the DIS region
Ageev ES, Alexakhin VY, Alexandrov Y, et al. Measurement of the spin structure of the deuteron in the DIS region. Phys.Lett. B. 2005;612(3-4):154-164.We present a new measurement of the longitudinal spin asymmetry Ad and the spin-dependent structure function g(1)(d) of the deuteron in the range 1 < Q(2) < 100 GeV2 and 0.004 < x < 0.7. The data were obtained by the COMPASS experiment at CERN using a 160 GeV polarised muon beam and a large polarised (LiD)-Li-6 target. The results are in agreement with those from previous experiments and improve considerably the statistical accuracy in the region 0.004 < x < 0.03. (c) 2005 Elsevier B.V. All rights reserved