4 research outputs found
Side effects of proton beam therapy of choroidal melanoma in dependence of the dose to the optic disc and the irradiated length of the optic nerve
No full textThe Political Ecology of Resource-based Inter-ethnic Violence: The Case of the Jarso and the Girhi in Eastern Ethiopia
No full text
The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study
No full textNatural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), -glucosidase (-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of -glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 3.70 +/- 0.92-79.66 +/- 20.81nM against hCA I, 2.98 +/- 0.33-84.88 +/- 40.32nM against hCA II, 4.93 +/- 2.01-593.60 +/- 134.74nM against -Gly, 0.52 +/- 0.18-46.80 +/- 17.15nM against AChE, and 1.25 +/- 0.22-32.08 +/- 2.68 against BChE
