Preparation and antimicrobial activity of gelatin microparticles containing propolis against oral pathogens

Gelatin microparticles containing propolis ethanolic extractive solution were prepared by spray-drying technique. Particle,, with regular morphology, mean diameter ranging of 2.27 mu m to 2.48 mu m, and good entrapment efficiency for propolis were obtained. The in vitro antimicrobial activity of microparticles was evaluated against microorganisms of oral importance (Enterococcus faecalis, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus mitis, Streptococcus mutans, Streptococcus sobrinus, Candida albicans, and Lactobacillus casei). The utilized techniques were diffusion in agar and determination of minimum inhibitory concentration. The choice of the method to evaluate the antimicrobial activity of microparticles showed be very important. The microparticles displayed activity against all tested strains of similar way to the propolis, showing greater activity against the strains of E. salivarius, S. sanguinis, S. mitis, and C albicans

Polysaccharide Containing Gels for Pharmaceutical Applications

WOS: 000456875000007Bio-derived polymers are falling into the needs of pharmaceutical formulations for topical applications due to their gelling ability. Generally, in topical delivery, as an alternative way for local and systemic application of active substances, formulations in gelling form are preferred as they have multiple advantages, e.g., minimize systemic side effects, avoid gastrointestinal irritation, prevent the metabolism of the active substance in liver, etc. The present chapter reviews bio-based polymers with special reference to polysaccharides-based hydrogels with respect to their pharmaceutical applications