8 research outputs found
Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice
<div><p>Congenital cytomegalovirus (CMV) infection is the most common non-hereditary cause of sensorineural hearing loss (SNHL) yet the mechanisms of hearing loss remain obscure. Natural Killer (NK) cells play a critical role in regulating murine CMV infection via NK cell recognition of the Ly49H cell surface receptor of the viral-encoded m157 ligand expressed at the infected cell surface. This Ly49H NK receptor/m157 ligand interaction has been found to mediate host resistance to CMV in the spleen, and lung, but is much less effective in the liver, so it is not known if this interaction is important in the context of SNHL. Using a murine model for CMV-induced labyrinthitis, we have demonstrated that the Ly49H/m157 interaction mediates host resistance in the temporal bone. BALB/c mice, which lack functional Ly49H, inoculated with mCMV at post-natal day 3 developed profound hearing loss and significant outer hair cell loss by 28 days of life. In contrast, C57BL/6 mice, competent for the Ly49H/m157 interaction, had minimal hearing loss and attenuated outer hair cell loss with the same mCMV dose. Administration of Ly49H blocking antibody or inoculation with a mCMV viral strain deleted for the m157 gene rendered the previously resistant C57BL/6 mouse strain susceptible to hearing loss to a similar extent as the BALB/c mouse strain indicating a direct role of the Ly49H/m157 interaction in mCMV-dependent hearing loss. Additionally, NK cell recruitment to sites of infection was evident in the temporal bone of inoculated susceptible mouse strains. These results demonstrate participation of NK cells in protection from CMV-induced labyrinthitis and SNHL in mice.</p></div
Lorentz violation and Crab synchrotron emission: a new constraint far beyond the Planck scale
Special relativity asserts that physical phenomena appear the same for all
inertially moving observers. This symmetry, called Lorentz symmetry, relates
long wavelengths to short ones: if the symmetry is exact it implies that
spacetime must look the same at all length scales. Several approaches to
quantum gravity, however, suggest that there may be a Lorentz violating
microscopic structure of spacetime, for example discreteness,
non-commutativity, or extra dimensions. Here we determine a very strong
constraint on a type of Lorentz violation that produces a maximum electron
speed less than the speed of light. We use the observation of 100 MeV
synchrotron radiation from the Crab nebula to improve the previous limits by a
factor of 40 million, ruling out this type of Lorentz violation, and thereby
providing an important constraint on theories of quantum gravity.Comment: 12 pages. Presentation shortened and revised for letter to Nature.
New title "A strong astrophysical constraint on the violation of special
relativity by quantum gravity". Maximum observed synchrotron frequency
lowered, resulting in weakening the constraint from E_QG>4.5*10^27 GeV to
E_QG>10^26 GeV. The role of the effective field theory assumptions underlying
the analysis is highlighte