Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: An analysis of nationwide data

Introduction: After antiretroviral therapy (ART) became available, there was a decline in the number of deaths in persons infected with HIV. Thereafter, there was a decrease in the proportion of deaths attributed to opportunistic infections and an increase in the proportion of deaths attributed to chronic comorbidities. Herein we extend previous observations from a nationwide survey on temporal trends in causes of death in HIV-infected patients in Brazil. Methods: We describe temporal trends in causes of death among adults who had HIV/AIDS listed in the death certificate to those who did not. All death certificates issued in Brazil from 1999 to 2011 and listed in the national mortality database were included. Generalized linear mixed-effects logistic models were used to study temporal trends in proportions. Results: In the HIV-infected population, there was an annual adjusted average increase of 6.0%, 12.0%, 4.0% and 4.1% for cancer, external causes, cardiovascular diseases (CVD) and diabetes mellitus (DM), respectively, compared to 3.0%, 4.0%, 1.0% and 3.9%, in the non-HIV group. For tuberculosis (TB), there was an adjusted average increase of 0.3%/year and a decrease of 3.0%/year in the HIV and the non-HIV groups, respectively. Compared to 1999, the odds ratio (OR) for cancer, external causes, CVD, DM, or TB in the HIV group were, respectively, 2.31, 4.17, 1.76, 2.27 and 1.02, while for the non-HIV group, the corresponding OR were 1.31, 1.63, 1.14, 1.62 and 0.67. Interactions between year as a continuous or categorical variable and HIV were significant (p <0.001) for all conditions, except for DM when year was considered as a continuous variable (p = 0.76). Conclusions: Non HIV-related co-morbidities continue to increase more rapidly as causes of death among HIV-infected individuals than in those without HIV infection, highlighting the need for targeting prevention measures and surveillance for chronic diseases among those patients. © 2014 Paula et al

Constraints from muon g-2 and LFV processes in the Higgs Triplet Model

Constraints from the muon anomalous magnetic dipole moment and lepton flavor violating processes are translated into lower bounds on v_Delta*m_H++ in the Higgs Triplet Model by considering correlations through the neutrino mass matrix. The discrepancy of the sign of the contribution to the muon anomalous magnetic dipole moment between the measurement and the prediction in the model is clarified. It is shown that mu to e gamma, tau decays (especially, tau to mu e e), and the muonium conversion can give a more stringent bound on v_Delta*m_H++ than the bound from mu to eee which is expected naively to give the most stringent one.Comment: 18 pages, 16 figure

Decoupling property of the supersymmetric Higgs sector with four doublets

In supersymmetric standard models with multi Higgs doublet fields, selfcoupling constants in the Higgs potential come only from the D-terms at the tree level. We investigate the decoupling property of additional two heavier Higgs doublet fields in the supersymmetric standard model with four Higgs doublets. In particular, we study how they can modify the predictions on the quantities well predicted in the minimal supersymmetric standard model (MSSM), when the extra doublet fields are rather heavy to be measured at collider experiments. The B-term mixing between these extra heavy Higgs bosons and the relatively light MSSM-like Higgs bosons can significantly change the predictions in the MSSM such as on the masses of MSSM-like Higgs bosons as well as the mixing angle for the two light CP-even scalar states. We first give formulae for deviations in the observables of the MSSM in the decoupling region for the extra two doublet fields. We then examine possible deviations in the Higgs sector numerically, and discuss their phenomenological implications.Comment: 26 pages, 24 figures, text sligtly modified,version to appear in Journal of High Energy Physic

Lepton Number Violation from Colored States at the LHC

The possibility to search for lepton number violating signals at the Large Hadron Collider (LHC) in the colored seesaw scenario is investigated. In this context the fields that generate neutrino masses at the one-loop level are scalar and Majorana fermionic color-octets of SU(3). Due to the QCD strong interaction these states may be produced at the LHC with a favorable rate. We study the production mechanisms and decays relevant to search for lepton number violation signals in the channels with same-sign dileptons. In the simplest case when the two fermionic color-octets are degenerate in mass, one could use their decays to distinguish between the neutrino spectra. We find that for fermionic octets with mass up to about 1 TeV the number of same-sign dilepton events is larger than the standard model background indicating a promising signal for new physics.Comment: minor corrections, added reference

The Hubble Constant

I review the current state of determinations of the Hubble constant, which gives the length scale of the Universe by relating the expansion velocity of objects to their distance. There are two broad categories of measurements. The first uses individual astrophysical objects which have some property that allows their intrinsic luminosity or size to be determined, or allows the determination of their distance by geometric means. The second category comprises the use of all-sky cosmic microwave background, or correlations between large samples of galaxies, to determine information about the geometry of the Universe and hence the Hubble constant, typically in a combination with other cosmological parameters. Many, but not all, object-based measurements give $H_0$ values of around 72-74km/s/Mpc , with typical errors of 2-3km/s/Mpc. This is in mild discrepancy with CMB-based measurements, in particular those from the Planck satellite, which give values of 67-68km/s/Mpc and typical errors of 1-2km/s/Mpc. The size of the remaining systematics indicate that accuracy rather than precision is the remaining problem in a good determination of the Hubble constant. Whether a discrepancy exists, and whether new physics is needed to resolve it, depends on details of the systematics of the object-based methods, and also on the assumptions about other cosmological parameters and which datasets are combined in the case of the all-sky methods.Comment: Extensively revised and updated since the 2007 version: accepted by Living Reviews in Relativity as a major (2014) update of LRR 10, 4, 200

Non-Standard Neutrino Interactions at One Loop

Neutrino oscillation experiments are known to be sensitive to Non-Standard Interactions (NSIs). We extend the NSI formalism to include one-loop effects. We discuss universal effects induced by corrections to the tree level W exchange, as well as non-universal effects that can arise from scalar charged current interactions. We show how the parameters that can be extracted from the experiments are obtained from various loop amplitudes, which include vertex corrections, wave function renormalizations, mass corrections as well as box diagrams. As an illustrative example, we discuss NSIs at one loop in the Minimal Supersymmetric Standard Model (MSSM) with generic lepton flavor violating sources in the soft sector. We argue that the size of one-loop NSIs can be large enough to be probed in future neutrino oscillation experiments.Comment: 27 pages, 4 figure

Constraints on exotic lepton doublets with minimal coupling to the standard model

We investigate the consequences of introducing a set of exotic doublet leptons which couple to the standard model leptons in a minimal way. Through these additional gauge invariant and renormalizable coupling terms, new sources of tree-level flavor changing currents are induced via mixing. In this work, we derive constraints on the parameters that govern the couplings to the exotic doublets by invoking the current low-energy experimental data on processes such as leptonic Z decays, $\ell \rightarrow 3 \ell'$, $\ell \rightarrow \ell' \gamma$, and $\mu$-$e$ conversion in atomic nuclei. Moreover, we have analyzed the role these doublets play on the lepton anomalous magnetic moments, and found that their contribution is negligible.Comment: 18 pages, 1 figure, 2 tables (REVTeX4.1); v2: added discussions in Sec.II, III & IX and new ref. To appear in JHEP. arXiv admin note: text overlap with arXiv:1011.473