11 research outputs found
The additive effects of atorvastatin and insulin on renal function and renal organic anion transporter 3 function in diabetic rats
- Author
- A Jais
- A Lungkaphin
- A Phatchawan
- AG Aslamkhan
- AT Reutens
- B Buranrat
- B Chogtu
- B Zhao
- DH Sweet
- Diagnosis and Classification of Diabetes Mellitus
- F Violi
- H Motohashi
- H Wang
- IK Aggeli
- J Deng
- JA Jefferson
- JL Jiang
- JV Busik
- K Jaikumkao
- K Jaikumkao
- L Baird
- L Ma
- M Cnop
- M Satoh
- MB Duran-Salgado
- MY Donath
- MY Donath
- N Kaiser
- R Ramasamy
- S Kudo
- S Promsan
- S Tian
- SC Tang
- T Ishii
- X He
- XJ Song
- Z Ungvari
- ZY Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Impaired Insulin Signaling Affects Renal Organic Anion Transporter 3 (Oat3) Function in Streptozotocin-Induced Diabetic Rats
- Author
- A Lungkaphin
- AA Bernardo
- AG Aslamkhan
- AL VanWert
- Anchalee Pongchaidecha
- Anusorn Lungkaphin
- AR Saltiel
- BB Moglia
- Chutima Srimaroeng
- CP Hodgkinson
- D Du Cheyron
- D Feliers
- DH Sweet
- DH Sweet
- G Bandyopadhyay
- G Gabriels
- Hideharu Abe
- J Kwan
- J Zdychová
- K Inui
- K Nagai
- KI Inui
- L Laviola
- L Xia
- L-Z Liu
- Lisa Chatsudthipong
- M Takano
- MJ Lee
- ML Sheu
- N Kang
- NA Wolff
- P Duan
- Phatchawan Arjinajarn
- Q Wang
- Q Zhang
- S Soodvilai
- S Soodvilai
- SA Barros
- T Sekine
- TS Chu
- Vara Fresno JA
- Varanuj Chatsudthipong
- W Shen
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
- Author
- A Bahn
- A Pavlova
- A Pavlova
- AG Aslamkhan
- BC Burckhardt
- CE Groves
- CE Lopez-Nieto
- CE Lopez-Nieto
- D Grundemann
- DA Bow
- DC Brater
- DH Sweet
- DH Sweet
- DH Sweet
- DH Sweet
- DH Sweet
- ES Ho
- G Kaler
- G Simonson
- G Xu
- G You
- G You
- GH Kim
- Gregory Kaler
- GW Schnabolk
- GW Schnabolk
- H Kusuhara
- H Miyazaki
- JA Cerrutti
- JC Monte
- JV Moller
- K Bleasby
- K Tanaka
- Kevin T Bush
- KP Brady
- M Hong
- M Ljubojevic
- MJ Dresser
- N Nakajima
- NA Wolff
- RAMH Van Aubel
- RK Zalups
- SA Eraly
- SA Eraly
- SA Eraly
- SA Eraly
- SA Eraly
- SA Eraly
- Sanjay K Nigam
- SC Buist
- SCN Buist
- SH Cha
- SH Wright
- T Fujita
- T Sekine
- T Sekine
- T Sekine
- V Bhatnagar
- Vibha Bhatnagar
- Y Nagata
- Y Nozaki
- Y Shitara
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio)
- Author
- A Bahn
- A Enomoto
- A Froschauer
- A Louis
- AG Aslamkhan
- AM Lamhonwah
- AN Rizwan
- AT Nies
- AT Nies
- B Hagenbuch
- B Kwok
- C Berthelot
- C Volk
- C Zhu
- CD Cropp
- G Ciarimboli
- GD Simonson
- H Koepsell
- H Koepsell
- H Koepsell
- H Koepsell
- H Motohashi
- H Shen
- H Tsuchida
- I Tamai
- I Tamai
- Ivan Mihaljevic
- J Nirmal
- JW Jonker
- K Howe
- KL Lee
- KY Jung
- L Pochini
- M Anisimova
- M Matthews
- M Nakakariya
- M Okabe
- M Popovic
- M Popovic
- M Popovic
- M Sato
- M Tachikawa
- Marta Popovic
- NA Wolff
- NG Markova
- P Simon
- PJ Höglund
- PM Smith
- PY Muller
- RC Edgar
- Roko Zaja
- S Guindon
- SA Eraly
- SA Eraly
- SA Eraly
- SE Gilchrist
- SK Nigam
- SS More
- T Okura
- T Zhang
- TJ Urban
- TL Bailey
- TN Winter
- Tvrtko Smital
- V Chatsudthipong
- W Sun
- W Wu
- Y Furuichi
- Y Meier
- Y Shu
- Y Urikami
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Physiology, structure, and regulation of the cloned organic anion transporters
- Author
- Abramson J
- Abramson J
- Ait Slimane T
- Anzai N
- Anzai N
- Anzai N
- Anzai N
- Apiwattanakul N
- Asif AR
- Aslamkhan AG
- Aslamkhan AG
- Astorga BO
- Babu E
- Babu E
- Bahn A
- Bahn A
- Bahn A
- Bakhiya A
- Bakhiya N
- Berger V
- Berkhin EB
- Bhatnagar V
- Bleasby K
- Bow DA
- Brady KP
- Buist SC
- Burckhardt BC
- Burckhardt G
- Burckhardt G
- C. Srimaroeng
- Capasso G
- Cerrutti JA
- Cerrutti JA
- Cerrutti JA
- Cha SH
- Cha SH
- Chakravarti A
- Cheong HI
- Choudhuri S
- Cihlar T
- Cross RJ
- Cui Y
- Dantzler WH
- Dantzler WH
- Dresser MJ
- Ekaratanawong S
- Enomoto A
- Enomoto A
- Enomoto A
- Enomoto A
- Eraly SA
- Eraly SA
- Erdman AR
- Feng B
- Feng B
- Fielding CJ
- Fritzsch G
- Fujita T
- Gekle M
- George RL
- Graessler J
- Groves CE
- Hagenbuch B
- Hagenbuch B
- Hagenbuch B
- Hagos Y
- Hagos Y
- Hasannejad H
- Hasegawa M
- Hashimoto T
- Hediger MA
- Hilgendorf C
- Hirai T
- Hirai T
- Hong M
- Hong M
- Hong M
- Hosoyamada M
- Hosoyamada M
- Huang YF
- Ichida K
- Ichida K
- Iida A
- Islinger F
- J. B. Pritchard
- J. L. Perry
- Jacobsson JA
- Jariyawat S
- Jenny M
- Kaler G
- Kaler G
- Khamdang S
- Kikuchi R
- Kikuchi R
- Kikuchi R
- Kimura H
- Klaassen CD
- Kobayashi Y
- Kobayashi Y
- Kobayashi Y
- Kobayashi Y
- Koepsell H
- Komoda F
- Kusuhara H
- Kuze K
- Kwak JO
- Kwak JO
- Kwak JO
- Lee SJ
- Lee W
- Ljubojevic M
- Ljubojevic M
- Lopez-Nieto CE
- Lu R
- Maesaka JK
- Marshall EKJ
- Marshall EKJ
- Marshall EKJ
- Marzolini C
- Miller D
- Miller DS
- Miyazaki H
- Monte JC
- Mori K
- Morita N
- Nishizato Y
- Ogasawara K
- Ogasawara K
- Ohtsuki S
- Ohtsuki S
- Pavlova A
- Perry JL
- Perry JL
- Petrick JS
- Popowski K
- Popp C
- Price KL
- Pritchard JB
- Pritchard JB
- Pritchard JB
- Pritchard JB
- Pritchard JB
- Race JE
- Reid G
- Rizwan AN
- Rizwan AN
- Robertson EE
- Rowntree LG
- Sabolic I
- Saji T
- Sauvant C
- Sauvant C
- Sauvant C
- Schinkel AH
- Schmitt C
- Schnabolk GW
- Sekine T
- Sekine T
- Shimada H
- Shitara Y
- Shitara Y
- Shuprisha A
- Simons K
- Simonson GD
- Smith HW
- Soodvilai S
- Sugiyama D
- Sun W
- Sweet DH
- Sweet DH
- Sweet DH
- Sweet DH
- Sweet DH
- Sykes D
- Tahara H
- Takeda M
- Takeda M
- Takeda M
- Takeda M
- Tanaka K
- Tanaka Y
- Taniguchi A
- Thompson D
- Ugele B
- Ullrich KJ
- Ullrich KJ
- Uwai Y
- Wakida N
- Weiner IM
- Weiner IM
- Whitley AC
- Wolff NA
- Wolff NA
- Wolff NA
- Wright SH
- Xu G
- Xu W
- Yang XP
- You G
- You G
- Youngblood GL
- Zalups RK
- Zalups RK
- Zalups RK
- Zhang XH
- Zhou F
- Zhou F
- Zhou F
- Zhou F
- Zhou F
- Zhou F
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease
- Author
- A Enomoto
- A Maeda
- A Monica Torres
- A Mulgaonkar
- AA Pozdzik
- AC Whitley
- AG Aslamkhan
- AL VanWert
- AM Torres
- AN Rizwan
- B Astorga
- C Fork
- C Kyrklund
- C Lebeau
- C Sauvant
- CC Wong
- CC Wong
- CH Yang
- D Lazzaro
- D Miura
- D Uetake
- DH Sweet
- DH Sweet
- DH Sweet
- Douglas H. Sweet
- E Babu
- F Zhou
- FD Debelle
- G Corrigan
- G Giusto Di
- GW Schnabolk
- H Saito
- H Sun
- H Tokuyama
- H Tsuchida
- H Yuan
- HJ Shin
- J Fleschhut
- J Honari
- J Naud
- J Zhang
- JE Shima
- JM Maher
- K Hocherl
- K Klein
- K Ogasawara
- K Ogasawara
- K Popowski
- K Wojcikowski
- KG Dickman
- KM Giacomini
- L He
- L Ji
- L Jin
- L Wang
- Li Wang
- M Kunin
- M Larsen
- M Ljubojevic
- M Miyajima
- M Nakamura
- M Rodiger
- M Sato
- MF Wempe
- MJ Cutler
- MK Choi
- N Bakhiya
- N Sato
- N Shobeiri
- O Kwon
- O Kwon
- P Duan
- PG Welling
- R Elsby
- R Kikuchi
- R Kikuchi
- R Nakagomi-Hagihara
- R Schneider
- R Schneider
- RS Bourke
- S Chiba
- S Li
- S Shibutani
- S Uchino
- SA Barros
- SA Eraly
- SI Myers
- SY Ahn
- T Cihlar
- T Li
- T Makino
- T Matsuzaki
- T Saji
- TM Rababah
- U Jaehde
- V Bhatnagar
- W Russell
- W Wegner
- WR Wikoff
- X Xue
- Y Lai
- Y Lou
- Y Sakurai
- Y Uwai
- Y Uwai
- Y Uwai
- Y Zeng
- Y Zhu
- YF Han
- Publication venue
- 'American Association of Pharmaceutical Scientists (AAPS)'
- Publication date
- Field of study
The neurobiology of zinc in health and disease
- Author
- A Baron
- A Baron
- A Birinyi
- A Muller
- A Riba-Bosch
- A Ruiz
- A Takeda
- AB Bloomenthal
- AF Quest
- AG Aslamkhan
- AG Estevez
- AG Reaume
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AL Friedlich
- AM Hosie
- AM Rosati
- AR Brooks-Kayal
- AR Kay
- AR White
- B Garrett
- B Holst
- B Laube
- B Regland
- BK Siesjo
- BL Vallee
- C Casanovas-Aguilar
- C Casanovas-Aguilar
- C Casanovas-Aguilar
- C Jacob
- C Opazo
- C Patton
- C Szabo
- CA McLean
- CA Rottkamp
- CB Sindreu
- CE Brown
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Frederickson
- CJ Maynard
- CL Masters
- CL Mitchell
- CL Mitchell
- CM Low
- CS Atwood
- CS Atwood
- CS Atwood
- CS Atwood
- CT Sheline
- CT Sheline
- CT Sheline
- CW Ritchie
- D Atar
- D Jiang
- D Lobner
- D Martin
- D Segal
- DA Coulter
- DC Whitcomb
- DD Lin
- DW Choi
- DW Choi
- DW Choi
- E Aizenman
- E Bossy-Wetzel
- E Head
- E Palma
- E Varea
- EE Kelland
- EH Buhl
- EK Richfield
- EY Kim
- FM Haug
- FM Haug
- FS Esch
- FW Sunderman Jr.
- G Charton
- G Danscher
- G Multhaup
- G Multhaup
- G Rosenberg
- G Swaminath
- G Wei
- GA Howell
- GA Kerchner
- GA Rameau
- GA Rameau
- GA Tejwani
- GG Glenner
- GL Westbrook
- GT Gustafson
- GW Albers
- H Haase
- H Kajita
- H Lin
- H Maske
- HC Ha
- HH Sandstead
- HZ Yin
- HZ Yin
- J Altman
- J Benters
- J Dong
- J Garcia-Colunga
- J Kapur
- J Mukai
- J Perez-Clausell
- JA Park
- JA Roe
- JA Schetz
- JA Schetz
- JC Easaw
- JC Sorensen
- JD Morton
- JH Weiss
- JH Weiss
- JH Weiss
- JH Weiss
- JM Berg
- JM Lee
- JS Yi
- JV Murphy
- JY Koh
- JY Koh
- JY Lee
- JY Lee
- JY Lee
- JY Lee
- K Hensley
- K Kretschmannova
- K Lock
- K Puttaparthi
- K Vogt
- KA Hossmann
- KJ Barnham
- KM Noh
- L Aniksztejn
- L Slomianka
- L Zirpel
- LH Kristiansen
- LL Coughenour
- LM Canzoniero
- M Hershfinkel
- M Itoh
- M Kawahara
- M Spiridon
- M Uki
- M Yokoyama
- MA Connor
- MA Lovell
- MA Smith
- MB Sorensen
- MD Shumate
- ME Quinta-Ferreira
- MI Dominguez
- MI Dominguez
- MM Siddiq
- MP Cuajungco
- MR Bennett
- MS Horning
- N Tonder
- O Thorlacius-Ussing
- P Dobsak
- P Fatt
- P Legendre
- P Manzerra
- P Marin
- P Molnar
- P Molnar
- P Paoletti
- PA Davies
- PA Sillevis Smitt
- PA Sillevis Smitt
- PC Hubbard
- PW Land
- Q Wu
- R Dyck
- RA Cherny
- RA Colvin
- RA Colvin
- RA Colvin
- RB Thompson
- RB Thompson
- RB Thompson
- RD Palmiter
- RD Palmiter
- RD Terry
- RJ Singh
- RJ Vandenberg
- RS Sloviter
- S Casagrande
- S Nagano
- S Peters
- S Turnbull
- S Ueno
- SA Bayer
- SA Bellingham
- SC Chattipakorn
- SE Tsirka
- SI Liochev
- SL Sensi
- SL Sensi
- SL Sensi
- SL Sensi
- SL Sensi
- SM Arab
- SR Seo
- SR Vincent
- ST Liu
- SW Suh
- SW Suh
- SY Assaf
- T Budde
- T Rehren
- TA Patterson
- TG Smart
- TG Smart
- TY Kim
- U Traversa
- VM Kolenko
- W Maret
- W Maret
- W Maret
- W Maret
- W Maret
- W Maret
- WN Green
- X Huang
- X Huang
- X Huang
- X Xie
- X Xie
- X Xie
- XM Xie
- Y Ben Ari
- Y Jia
- Y Li
- Y Li
- Y Shen
- Y Uchida
- Y Yang
- YH Gong
- YH Kim
- YH Kim
- YH Kim
- YM Lu
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mechanisms involved in the transport of mercuric ions in target tissues
- Author
- A Bahn
- A Naganuma
- A Yasutake
- AA Jernelov
- AG Aslamkhan
- AK Kristensen
- AL Betz
- AS Koh
- B Rowens
- BC Burckhardt
- BJ Fuhr
- C Garcia-Ruiz
- C Rahner
- CA Wagner
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CC Bridges
- CD Klaassen
- Christy C. Bridges
- CS Oliveira
- CS Oliveira
- CS Prickett
- D Breljak
- D Keppler
- D Rost
- DA Aremu
- DC Holzman
- DH Roos
- DJ Thomas
- DJ Thomas
- DK Kim
- DM Ward
- E Mussini
- EC Foulkes
- EC Foulkes
- EM Leslie
- EM Mokrzan
- ER Samuels
- F Canonne-Hergaux
- F Islinger
- F Planas-Bohne
- F Thiebaut
- FM Rubino
- G Wu
- G Wu
- G Wu
- GB Segel
- GD Simonson
- GG Berg
- GL Diamond
- H Cember
- H Gibb
- H Iioka
- H Matsumoto
- H Motohashi
- HH Harris
- HL Friedman
- HM Prime-Chapman
- HV Aposhian
- HV Aposhian
- I Heggland
- I Hoyle
- I Tamai
- J Chillaron
- J de Ceaurriz
- J de Ceaurriz
- J Konig
- J Ohlander
- J Seccatore
- J Warkany
- JC Fernandez-Checa
- JC Fernandez-Checa
- JF Afonso
- JG Joshi
- JJ Leaner
- JL Ambrose
- JL Lin
- JL Sloan
- JM Laporte
- JM Maher
- JP Soni
- K Ask
- K Hirayama
- K Hirayama
- K Hirayama
- K Nakazawa
- KD Lundgren
- KM Jaffe
- KM Mulder
- L Amin-Zaki
- L Friberg
- L Friberg
- L Landner
- L Magos
- L Magos
- L Magos
- L Magos
- LE Kerper
- LJ Hahn
- LT Zimmermann
- LT Zimmermann
- M Aschner
- M Aschner
- M Aschner
- M Aschner
- M Aschner
- M Berlin
- M Berlin
- M Buchler
- M Carmignani
- M Estudante
- M Harada
- M Harada
- M Henjakovic
- M Hosoyamada
- M Inouye
- M Inouye
- M Inouye
- M Maliepaard
- M Palacin
- M Palacin
- M Rallo
- M Rodiger
- M Vazquez
- M Vazquez
- M Vazquez
- MH Dave
- MJ Murphy
- ML Vlaming
- MS Kilberg
- MS Madejczyk
- MV St-Pierre
- N Anzai
- N Ballatori
- N Ballatori
- N Ballatori
- N Ballatori
- N Ballatori
- N Ballatori
- N Ballatori
- N Ballatori
- N Sugawara
- ND Pfeifer
- NG Ilback
- P Di Simplicio
- P Hultman
- P Hultman
- P Hultman
- P Hultman
- P Marbet
- PG Simpson
- PM Rodier
- PW Davidson
- R Kojima
- R Taugner
- R Taugner
- RB Simpson
- RE Bluhm
- RJ Boado
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- RK Zalups
- Rudolfs K. Zalups
- S Andres
- S Fraga
- S Itagaki
- S Lau
- S Liang
- S Nagamori
- S Omata
- SH Cha
- SI McNeil
- T Endo
- T Gonska
- T Jansson
- T Nakanishi
- T Norseth
- T Norseth
- T Norseth
- T Refsvik
- T Refsvik
- T Refsvik
- T Sekine
- T Sekine
- T Shoji
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka-Kagawa
- T Urano
- T Yokooji
- TA Simmons-Willis
- TM Leazer
- TP Akerboom
- TP Schaub
- TP Schaub
- TW Clarkson
- TW Clarkson
- TW Clarkson
- V Ganapathy
- VT Cannon
- VT Cannon
- W Wang
- WF Ashe
- WH Oldendorf
- WHO
- WJ Dutczak
- WJ Dutczak
- WJ Dutczak
- WL Hughes
- WO Berndt
- X Ming
- Y Kajiwara
- Y Kajiwara
- Y Kajiwara
- Y Kudo
- Y Wakita
- Z Gregus
- Z Yin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Renal Drug Transporters and Drug Interactions.
- Author
- A Allen
- A Amphoux
- A Aslamkhan
- A Azzariti
- A Brandoni
- A Collett
- A Courtois
- A Crowe
- A Dahan
- A Dahan
- A Dahan
- A Dahlin
- A D’Emanuele
- A Enomoto
- A Enomoto
- A Futatsugi
- A Gaowa
- A Geick
- A Gupta
- A Hamada
- A Horie
- A Kamizono
- A Kawase
- A Koenen
- A Komatsuda
- A Kunze
- A Lazar
- A Lespine
- A Maeda
- A Maeda
- A McCormick
- A Milane
- A Mulgaonkar
- A Nakayama
- A Nies
- A Oka
- A Ose
- A Owen
- A Pawarode
- A Poirier
- A Rizwan
- A Servais
- A Soldner
- A Somogyi
- A Somogyi
- A Somogyi
- A Somogyi
- A Vildhede
- A Yamada
- A Yamada
- A Yonezawa
- A Yonezawa
- AA El-Sheikh
- AA Ela El
- AA Somogyi
- AA Somogyi
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AB Shapiro
- AE Busch
- AE Herwaarden van
- AE Kim
- AG Hotchkiss
- AH Schinkel
- AH Schinkel
- AH Schinkel
- AJ Dudley
- AJ Dudley
- AJ Scheen
- AL Dzierlenga
- AL VanWert
- AL VanWert
- AL Walker
- AM Al-Mohizea
- AM Bergman
- AM Hecken van
- AN Shaik
- Anton Ivanyuk
- AR Asif
- AS Mulato
- AS Ray
- AS Windass
- AS Windass
- AT Nies
- AT Wolman
- B Astorga
- B Feng
- B Feng
- B Fleisher
- B Greiner
- B Grover
- B Grover
- B Haenisch
- B Poller
- B Wenge
- BAC Acker van
- BC Burckhardt
- BC Ferslew
- BG Hardy
- BG Hardy
- BH Long
- BJ Gurley
- BL Lum
- BL Mason
- BM Schmitt
- BP Kearney
- BR Green
- C Chen
- C Chen
- C Chu
- C Fahrmayr
- C Fellner
- C Grammen
- C Hilgendorf
- C Jacobs
- C Jagannath
- C Kasserra
- C Kyrklund
- C Li
- C Luna-Tortós
- C Marzolini
- C Min-Koo
- C Pauli-Magnus
- C Pauli-Magnus
- C Pauli-Magnus
- C Pontier
- C Schmitt
- C Srimaroeng
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- Y Uwai
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- Y Uwai
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- Y Uwai
- Y Uwai
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- Y-F Cheng
- Y-H Han
- Y-H Zhang
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- YA Chen
- YH Oh
- YH Peng
- YR Ma
- Z Cheng
- Z Gai
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- Z Shen
- Z Tong
- Z Yang
- Z-J Wang
- ZS Chen
- ZS Chen
- ZS Chen
- ZS Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2017
- Field of study
Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug resistance protein (MRP) 2, MRP4, OATP1A2 and breast cancer resistance protein (BCRP) on the apical side. Organic cations are secreted by organic cation transporter (OCT) 2 on the basolateral side, and multidrug and toxic compound extrusion (MATE) proteins MATE1, MATE2/2-K, P-glycoprotein, organic cation and carnitine transporter (OCTN) 1 and OCTN2 on the apical side. Significant drug-drug interactions (DDIs) may affect any of these transporters, altering the clearance and, consequently, the efficacy and/or toxicity of substrate drugs. Interactions at the level of basolateral transporters typically decrease the clearance of the victim drug, causing higher systemic exposure. Interactions at the apical level can also lower drug clearance, but may be associated with higher renal toxicity, due to intracellular accumulation. Whereas the importance of glomerular filtration in drug disposition is largely appreciated among clinicians, DDIs involving renal transporters are less well recognized. This review summarizes current knowledge on the roles, quantitative importance and clinical relevance of these transporters in drug therapy. It proposes an approach based on substrate-inhibitor associations for predicting potential tubular-based DDIs and preventing their adverse consequences. We provide a comprehensive list of known drug interactions with renally-expressed transporters. While many of these interactions have limited clinical consequences, some involving high-risk drugs (e.g. methotrexate) definitely deserve the attention of prescribers
What do drug transporters really do?
- Author
- A Bahn
- A Brandoni
- A Dehghan
- A Emami Riedmaier
- A Enomoto
- A Hosomi
- A Konieczna
- A Krupoves
- A Maeda
- A Maeda
- A Ose
- A Pavlova
- A Schlessinger
- A Tin
- AC Keebaugh
- AE van Herwaarden
- AG Aslamkhan
- AK Tiwari
- AL VanWert
- AL VanWert
- AM Lamhonwah
- AM Torres
- AN Rizwan
- AS Mulato
- AS Windass
- B Gao
- B Hagenbuch
- B Hagenbuch
- B Hsiang
- C Eisner
- CA Farthing
- CC Wong
- CD Cropp
- CD Klaassen
- CE Lopez-Nieto
- CE Lopez-Nieto
- CM Crill
- D Ahmadimoghaddam
- D Beyoglu
- D Campa
- D Iusuf
- D Keppler
- D Nakai
- D Voora
- DB Mount
- DE Sweeney
- DF Carr
- DH Sweet
- DH Sweet
- DM Truong
- DS Miller
- E Banoglu
- E Hosseini
- E Link
- E Lopez-Lopez
- E Sparks
- E van de Steeg
- E Zazimalova
- EC Chow
- EI Lepist
- ER Lepper
- F Duranton
- F Staud
- F Zhou
- G Burckhardt
- G Ciarimboli
- G Kaler
- G Kaler
- G Martovetsky
- G Merino
- G Minuesa
- G Xu
- GD Kruh
- GL Lorca
- GT Ho
- GW Schnabolk
- H Braunlich
- H Kimura
- H Koepsell
- H Lu
- H Matsuo
- H Saito
- H Sakurai
- H Yano
- HW Smith
- I Tamai
- I Thiele
- J Alcorn
- J Naud
- J Nezu
- J Vazquez-Mellado
- J Wang
- J Weiss
- JB Hook
- JB Pritchard
- JC Monte
- JD Schuetz
- JE Keskitalo
- JH Choi
- JM Burnell
- JR Good
- JR Riordan
- JS Lagas
- JS Lagas
- JS Lagas
- JW Jonker
- JW Jonker
- JW Jonker
- K Engstrom
- K Ichida
- K Ikemura
- K Mori
- K Noguchi
- K Sharma
- K Shiraya
- K van de Wetering
- KJ Prentice
- KK Filipski
- KM Giacomini
- KM Giacomini
- KM Morrissey
- KM Morrissey
- KP Brady
- KT Bush
- KT Kivisto
- KY Ohta
- L Gong
- L Vecsei
- L Wang
- LC Strader
- LE Shipp
- LM Nix
- M Alebouyeh
- M Aouida
- M Geisler
- M Hirano
- M Kolz
- M Mazzali
- M Niemi
- M Nishimura
- M Poguntke
- M Roth
- M Sasaki
- M Takeda
- M Takeda
- M Tsuda
- M Tsuda
- MA Nagle
- MA Nagle
- MA Seeger
- MJ Huang
- MJ Zamek-Gliszczynski
- MK DeGorter
- ML Vlaming
- ML Vlaming
- ML Vlaming
- MM Christensen
- MM Gottesman
- MM Gottesman
- MV Tzvetkov
- N Bakhiya
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- P Borst
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- RK Zalups
- RS Funk
- S Buscemi
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- S Tokuhiro
- S Waller
- SA Eraly
- SA Eraly
- SA Eraly
- SA Eraly
- SA Eraly
- SA Eraly
- Sanjay K. Nigam
- SC Lee
- SC Tang
- SD de Jonge-Peeters
- SE Gilchrist
- SG Aller
- SH Cha
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- SK Nigam
- SL Stocker
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- YF Han
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- YM Weaver
- YY Sautin
- Z Redzic
- Z Szallasi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study