4 research outputs found
Hormonal regulation of circuit function: sex, systems and depression
- Author
- A Baskaran
- A Deslandes
- A Fernandez-Guasti
- A Glass
- A Miller
- A Schroeder
- A Tripp
- AA Fingelkurts
- AA Walf
- AF Leuchter
- AF Leuchter
- AK Engel
- AMI Barth
- AS Korb
- B Czeh
- B Feige
- B Saletu
- B Saletu
- B Saletu
- B Silverstein
- B Silverstein
- C Nystrom
- CA Frye
- CB Manna
- CP Brotzner
- CP Brotzner
- D Becker
- D Maciag
- D Pizzagalli
- D Spronk
- DA Pizzagalli
- DJ Dijk
- DR Rubinow
- DR Rubinow
- E Estrada-Camarena
- E Jesulola
- E Sibille
- EC Hinton
- G Akdeniz
- G Buzsaki
- G Buzsaki
- G MacKenzie
- G Rajkowska
- G Yilmaz
- GC Blackhart
- GD Jacobs
- GE Bruder
- GE Bruder
- GE Bruder
- GE Bruder
- GE Bruder
- GE Gillies
- GJ Wagner
- H Alhaj
- H Lier van
- HB Howell
- I Ferando
- I Rio-Portilla Del
- I Rudolph
- IA Cook
- IA Cook
- IH Gotlib
- IL Ward
- J Angst
- J Coope
- J Cunningham
- J Gross
- J Juarez
- J Juarez
- J Maguire
- J Palope
- JA Coan
- JB Henriques
- JB Henriques
- JB Nitschke
- JD Herrington
- JG Beaumont
- JJB Allen
- JL Gordon
- JL Stewart
- JL Stewart
- JM Broadway
- JM Spielberg
- JR Hughes
- K Cheslack-Postava
- K Domschke
- K Hugdahl
- K Monakhov
- KL Edinger
- KL Edinger
- L Martinez-Mota
- L Yang
- LC Lin
- LD McCauley
- LH Li
- LM Kentgen
- M Arns
- M Bares
- M Corsi-Cabrera
- M Corsi-Cabrera
- M Corsi-Cabrera
- M Corsi-Cabrera
- M Matousek
- M Matsuura
- M Olioff
- M Solis-Oritz
- MB Knable
- ME Addis
- MH Bjork
- MJ Meaney
- MK Arikan
- ML Morgan
- MP Heuvel Van den
- MS Man
- MT McKenna
- N Chauveau
- N Jaworska
- N Papp
- OD Creutzfeldt
- OL Smart
- OM Bazanova
- P Flor-Henry
- P Flor-Henry
- P Fries
- P Sauseng
- P Soderstan
- P Uhlhaas
- P Willner
- PR Albert
- R Krug
- R Nusslock
- R Thibodeau
- RA Rosellini
- RJ Davidson
- RJ Davidson
- RL Hawke
- RL Sumner
- RW Keunen
- S Debener
- S Moratti
- S Nolen-Hoeksema
- S Tement
- SA Reid
- SC Reed
- SI Goncalves
- SN Seidman
- SN Seidman
- T Fuchs
- T Molina-Jimenez
- TJ Shors
- U Schweiger
- VA Feshchenko
- W Heller
- W Heller
- W Hu
- W Wharton
- W Zhang
- WJ Neumann
- WK Marsh
- Y Li
- YC Wu
- Z Perova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Parasitic Infections of the Genito-urinary Tract
- Author
- A Abdullah
- A Alexieff
- A Andeh
- A Araventinos
- A Castellani
- A Castellani
- A Castellani
- A Castellani
- A Cioffi
- A Cornell
- A Custem-Franco
- A Donné
- A Donosainfante
- A Elliot
- A Gambier
- A Grassi
- A Grimaldi
- A Hagen
- A Ibrahim
- A Libbôa
- A Lichtenstein
- A Lightstone
- A Longo
- A Loos
- A Massimino
- A Mattei
- A Nogueira
- A Panayotatou
- A Panayotatou
- A Panayotatou
- A Pasma
- A Pena
- A Pijper
- A Pulido-Martin
- A Rauber
- A Riley
- A Schmidt
- A Trabucco
- A Travella
- A Westphal
- A. E. Woodhead
- A. E. Woodhead
- A. E. Woodhead
- A. R. Ferguson
- AA Diaz Colodrero
- AA Grimaldi
- AA Pacheco
- AB Sarewitz
- AC Chandler
- AC Chandler
- AC Chandler
- AC Curtis
- AC Drummond
- AC Lovett-Campbell
- AC Pipkin
- AD Armbrust
- AD Cisneros
- AE Giirsel
- AE Mcculloch
- AE Palmer
- AE Sitzen
- AE Woodhead
- AF Oritz
- AG Atwell
- AG Martynyuk
- AH Burr
- AH Schroeder
- AJ Bearup
- AJ Chalmers
- AJ Chalmers
- AJ Haddow
- AJ Hinkelmann
- AL Chute
- Alves
- AM Atakan
- AM Elwr
- AR Ferguson
- AR Santaella
- AR Stevens
- AS Mohammed
- AS Warthin
- AV Machado
- B Klinger
- B Lewis
- B Meillon
- B. J. Boucin
- BF Pecherskii
- BG Triay
- BH Kean
- BH Kean
- Biccheler
- Biccheler
- C Baumeister
- C Dobell
- C Farmakidis
- C Krakower
- C Marks
- C Romiti
- C Wegelin
- C Younger
- C. H. Venkateswaren
- Cassoute
- CC Hewitt
- CE Hercus
- CE Towne
- CF Craig
- CF Cropper
- CF Engelhard
- CH Barlow
- CH Barlow
- CH Kellaway
- CH Mattei
- CL Deming
- CL Straith
- CM Africa
- CM Greenslade
- Compstok
- Coneglio
- CR Lopez-Neyra
- CV Zerbini
- CW Anderson
- D Antonio Jr.
- D Givrer
- D Jeremié
- D Jeremié
- D Kirsch
- D Soubignon
- D Turner
- D Turner
- D Valle
- D Zanalda
- Dahl
- DB Rosenthal
- DD Albers
- DE Murray
- Desage
- DH Wenrich
- DH Wenrich
- DK Edwards
- DS Ridley
- Dzhavan
- Dztiandznag-Azou
- D’Haennens
- E Baelz
- E Billings
- E Bonnecarrere
- E Castano
- E Colombo
- E Dias
- E Grance
- E Knight
- E Leduc
- E Massal
- E Navahette
- E Nocard
- E Ortiz-Rivas
- E Piraaii
- E Ruggieri
- E Savitsch
- E Truc
- E. A. King
- EA Mills
- EA Rivas
- EB Rogers
- EC Mekie
- ED Casco
- ED Greig
- EF King
- EG Carillo
- EH Cluver
- EJ Shreson
- EK Markell
- EL Cornell
- EL Vila
- EL Vila
- Elsdon-Dew
- EM Fisher
- EP Mumford
- ER Brygoo
- ER Eastman-Nagle
- ER Reay
- ER Riay
- ER Riay
- ES Oliviera
- ES Patton
- ES Pomeroy
- ES Sayegh
- ES Sayegh
- ET Willans
- EW Beach
- EW Masterman
- EW Stunkard
- F Balsamelli
- F Bilger
- F Conant
- F Cozza
- F Dily
- F Dily
- F Graziani
- F Hawking
- F Küchenmeister
- F Lanoeley
- F Lanoeley
- F Lanoeley
- F Loesch
- F Marchand
- F Meersseman
- F Narabayashi
- F Ouzilleau
- F Ronnike
- F Santacruz
- F Smith
- F Yatsenko
- F Yatsenko
- F Zini
- F Zumpt
- F Zumpt
- F. B. Hartley
- F. T. Crossling
- FD Thomas
- FG Cawston
- FG Cawston
- FH Redewill
- FL Nino
- FO Dobritz
- FW Davis
- G Ambomim
- G Armitage
- G Aronica
- G Blanc
- G Bucco
- G Chevalier
- G Cocco
- G Craig
- G Derrico
- G Desusclade
- G Dock
- G Fiorito
- G Francini
- G Franohini
- G Franohini
- G Franohini
- G Franohini
- G Franohini
- G Iacapraro
- G Maclean
- G Millul
- G Olivieri
- G Penso
- G Penso
- G Perl
- G Placitelli
- G Ravasini
- G Rintelen
- G Rossi
- G Sesia
- G Spanu
- G Zedda
- G. B. Bartlett
- GC Allison
- GC Rocca
- GC Thooris
- Gowea
- GW Moor-House
- H Bauer
- H Berner
- H Galliard
- H Galliard
- H Grove
- H Held
- H Jungrans
- H Legrand
- H Leonhardt
- H Odland
- H Sharaf
- H. W. Brown
- HA Baylis
- HA Neves
- Halawani
- Halawani
- HB Herman
- HC Hesseltine
- HE Bowman
- HF Arredondo
- HF Carter
- HF Meyers
- HI Lurie
- HI Lurie
- HJ Keutel
- HJ Keutel
- HK Beye
- HK Beye
- HL Kretschmer
- HL Liu
- HM Weyrauch
- HO Mönnig
- Houzel
- HR Dew
- HR Sauer
- HW Plaggemeyer
- HW Shik
- I Bennie
- I Bennie
- I Carneri
- I Maisels
- I Maisels
- I. S. Hilmy
- IL Imazappratie
- IR Berger
- J Aleixo
- J Aulong
- J Azzena
- J Bartlakowski
- J Ciurea
- J Clastrier
- J Dawson
- J Ducving
- J Frunikin
- J Gutart
- J Howship
- J Israel
- J Jua
- J Khouri
- J Khouri
- J Khouri
- J Kozlowski
- J Krejci
- J Mackenzie
- J Mackenzie
- J Puig-Syreda
- J Rementeria
- J Rivoir
- J Schwetz
- J Serfling
- J Tanaka
- J Tenenbaum
- J Vergez
- J Walkiers
- J. E. R. Mcdonagh
- J. T. Lewis
- JA Davies
- JA Huarte
- JA Kieser
- JA Ross
- JA Ross
- JB Bernstine
- JB Muir
- JC Ferrer
- JD Baistrocchi
- JD Caeiro
- JE Glen Jr.
- JF Kessel
- JF Kessel
- JF Murray
- JG Feinberg
- JG Rohn
- JH Grindley
- JH Marks
- JH Salisbury
- JJ Diaz
- JJ Pereda
- JL Pawan
- JM Allende
- JM Beattie
- JM Madinaveitra
- JM Madinaveitra
- JM Watson
- JM Watson
- JM Watson
- JM Watson
- JM Watson
- JN Lucena
- JR Goyena
- JR Rossell
- JS Gilliam
- JW Bisher
- JW Draper
- JW Macfie
- JW Peabody Jr.
- JW Visiter
- K Matsuda
- K Uhlir
- K. O. Manohar
- KD Fairley
- KD Fairley
- KD Fairley
- KI Gurkon
- KJ Karnaky
- KN Ojha
- KS Shah
- Külz
- L Alcay
- L Alcay
- L Compagnon
- L Déjou
- L Déjou
- L Morenas
- L Nevill
- L Oller
- L Paterni
- L Potenza
- L Rebaudi
- L Sabadini
- L Sabadini
- L Veau
- L Visnjouski
- L. J. Davis
- L. P. Gabrod
- LA Jankovski
- LA Sanjurjo
- LA Surraco
- LB Goldschmidt
- LC Venturi
- LD Arrúes
- LD Arrúes
- LE Barnett
- LE López
- LE Mccrea
- LF Freed
- LG Feo
- LG Feo
- LG Stühler
- LR Alves
- LR Molina
- LR Molina
- LR Penner
- LW Riba
- LW Riba
- LW Riba
- Léger
- M Bottou
- M Buctmann
- M Capinceff
- M Casile
- M Castle
- M Eiken
- M Erfan
- M Fernandez
- M Gelfand
- M Gelfand
- M Gelfand
- M Gelfand
- M Gelfand
- M Gerbasi
- M Girolami
- M Hartmann-Keppel
- M Imbert
- M Imbert
- M Khalil
- M Koller
- M Leclerq
- M Llanos
- M Moore
- M Parent
- M Pesqueira
- M Petzetakis
- M Petzetakis
- M Petzetakis
- M Petzetakis
- M Rodecurt
- M Rodecurt
- M Saujeon
- M Schubert
- M Segurola
- M Sorrentino
- M Straub
- M Touzl
- M. A. Haseeb
- M. H. Sinz
- M. J. Wiittingdon
- MA Afifi
- MA Popoy
- Magueur
- Martinez-Fortuna
- Mcdonald
- MF Sokour
- MG Moentegart
- MH Shakir
- Miyigawa
- MJ Geyman
- MJ Hogue
- MJ Wiittingdon
- MJ Wiittingdon
- MK Moulder
- MM Grose
- MM Liakhovitsky
- MN Chatterjee
- MN De
- MO Nolan
- Montalvo
- Moore
- MR Castex
- MR Castex
- MR George
- MS Ferguson
- MS Hovenaniak
- MV Ramanamurti
- N Dujngal
- N Dujngal
- N Fiessinger
- N Leon
- N Makar
- N Makar
- N Makar
- N Mascall
- N Vladislavlev
- NC Begg
- NC Davis
- NC Day
- NF Conant
- NH Fairley
- NH Fairley
- NH Fairley
- NH Fairley
- NH Fairley
- NH Fairley
- Nilnez
- NJ Heckel
- NK Kimbell
- NK Kimbell
- NM Cowan
- NS Ivanova
- NV Bedarida
- O Bollinger
- O Chereffeddin
- O Cignozzt
- O Grimm
- O Margarucciii
- O Margarucciii
- O Uffreduzzi
- O Wucherer
- OC Snyder
- OD Standen
- OS Lowsley
- P Alvaro
- P Barbellion
- P Brunelli
- P Bruni
- P Caubet
- P Damgaard-Morch
- P Gourvitch
- P Grracd
- P Grracd
- P Hennebert
- P Holm
- P Holm
- P Jordan
- P Jordan
- P Kostie
- P Kostik
- P Kouri
- P Largrero Ybarz
- P Melvin
- P Nazzaro
- P Ravaut
- P Stuertz
- P Stuertz
- P Vichrev
- PA Morales
- PG Smith
- PH Hartz
- PH Nitsche
- PH Nitsche
- PL Ceresto
- PL Drouet
- PL Mirizzi
- PL Mirizzi
- PM Fernandez
- PM Rodó
- PN Ray
- PN Ray
- PS Mtganwa
- PW Aschner
- R Bachrach
- R Bernardi
- R Bernardi
- R Blanchard
- R Chevrel
- R Cooherque
- R Couvelaire
- R Crosnier
- R Ercole
- R Ercole
- R Girotto
- R Hegner
- R Hoeppli
- R Leuckart
- R Leuckart
- R Onorata
- R Piedrahita
- R Pons
- R Santos
- R Santos
- R Siebenthal
- R Spurr
- R Viviani
- R Whitehall
- R. R. Willcok
- R. S. Saviege
- RA Rubí
- RA Rubí
- RB Greenblatt
- RB Mclean
- RB Roth
- RC Becg
- RC Becg
- RC Becg
- RC Becg
- RC Begg
- RC Begg
- RC Begg
- RC Ferrari
- RD Canard
- RD Diaz
- RE Duzen
- RE Kuntz
- RE Strain
- RE Trussel
- RE Trussel
- RG Archibald
- RH Engert
- RH Hepburn
- RJ Ortlepp
- RK Finley
- RK Krikent
- RL Schrader
- RL Wezel
- RL Wezel
- RL Young
- RL Young
- RM Dimmette
- RM Dimmette
- RM Honey
- RM Stabler
- RM Yeo
- RO Ward
- RS Hawes
- RV Lopez
- RV Zalazar
- S Alzahawi
- S Annecke
- S Annecke
- S Burkert
- S Cerqua
- S Davidovic
- S Ferrandu
- S Gorman
- S Hirst
- S Ishikawa
- S Kamalou
- S Kitamura
- S Markowski
- S Spadaro
- S. A. Seligman
- SG Cowper
- SK Dastidar
- SL Brim
- SR Bushby
- SS Rao
- Surraco
- SV Humphries
- T Bilharz
- T Gerritsen
- TB Menon
- TC Allbutt
- TG Mcdougall
- Trumbull
- TS Cobbold
- U Cesarono
- U Granelli
- U Stefano
- US Howarth
- V Compan
- V Compan
- V Giuduceandrea
- V Giuduceandrea
- V Nicaise
- V Vermooten
- Vucong-Hoe
- VZ Cope
- W Alves
- W Alves
- W Baurys
- W Lewin
- W Robitschek
- W Roth
- W Tomoff
- WA Barrett
- WD Anthony
- WD Winter Jr.
- WE Coutts
- WE Coutts
- WE Coutts
- WE Dickson
- WE Erich
- WG Hayward
- WG Liston
- WG Liston
- WH Harvey
- WH Powell
- WJ Latham
- WJ Stauwitz
- WL Barton
- WL Barton
- WL Forsyth
- WM Coppridge
- WP Dakin
- WT Cummins
- WV Macfarlane
- WV Macfarlane
- WW Cort
- YM Elgort
- ZD Hahine
- ZT Bercovitz
- ZT Martin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1959
- Field of study
Long-term (180-Day) outcomes in critically Ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
- Author
- Abbass H
- Abdeladim L
- Abdelhady H
- Abdelkharim H
- Abdelrazik M
- Abdi Z
- Abdukahil SA
- Abel L
- Abraham J
- Abrahamson G
- Abusamra Y
- Aceto R
- Adams P
- Adebambo O
- Adhikari N
- Affleck J
- Agha G
- Aghemo A
- Agno R
- Aguilar-Dano A
- Ahmad N
- Ain Q
- Ainscough K
- Ainsworth J
- Aitken L
- Akamp C
- Al Enezi F
- Al-Bassam W
- Al-Beidh F
- Albert M
- Albrett J
- Alderink B
- Alderman M
- Alegria A
- Alexander B
- Alexander P
- Alfonso J
- Ali F
- Ali M
- Ali M
- Allam H
- Allen B
- Allen L
- Allibone S
- AlQahtani S
- Alswaidan L
- Altaf W
- Altomy M
- Al Amri A
- Al Qasim E
- Amatya S
- Ambrosino R
- Anders J
- Anderson T
- Andreae M
- Andric Z
- Aneman A
- Angus DC
- Anjum A
- Ankert J
- Annane D
- Anne-Laure F
- Anstey M
- Antcliffe D
- Anthony A
- Antoine M
- Antoine P
- Anumakonda V
- Aparicio C
- Arabi YM
- Arachchige M
- Aravindan L
- Arbane G
- Archer S
- Aref N
- Arias A-M
- Arias S
- Arishi H
- Arnold D
- Arnold J
- Aryal D
- Asghar A
- Asif N
- Aspinwall A
- Attanayaka U
- Attokaran A
- Attwood B
- Au C
- Austin K
- Austin P
- Avard B
- Awan S
- Azaiz A
- Azergui N
- Azzaui H
- Babel J
- Babu S
- Bacon G
- Badalamenti S
- Badie J
- Bagavathy K
- Bagot C
- Bagshaw S
- Baig N
- Baikady R
- Baillie K
- Bain W
- Baker E
- Baker S
- Bakthavatsalam D
- Balaie M
- Bamford A
- Bamford P
- Banach D
- Bannard-Smith J
- Barbash I
- Barbazza L
- Barber R
- Barbier F
- Barge D
- Bari S
- Bariola R
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- Baron R
- Barreau A
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- Bartley S
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- Bassford C
- Bastola S
- Bastos JMPS
- Bates M
- Bates S
- Batista TMO
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- Bayne M
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- Beane A
- Beard G
- Beasley R
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- Bhandal K
- Bhattarai B
- Bhimani Z
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- Binnie A
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- Bland Y
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- Borislavova B
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- Bossard I
- Boulanger M-C
- Boumahni D
- Bouman A
- Bounab R
- Bourgoin C
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- Bouvier E
- Bouw-Ruiter M
- Boué Y
- Bowen D
- Bowen J
- Bowler H
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- Brajković A
- Brakké K
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- Brightling C
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- Brohi F
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- Burns D
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- Stavor D
- Stedman R
- Steffen M
- Stephanie G
- Sterba M
- Stevenson L
- Stewart R
- Stone S
- Stratton E
- Stronach LM
- Studer A
- Suber T
- Sukuraman A
- Summerfield A
- Summers C
- Sundaram R
- Sundaran D
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- Szőke V
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- Tallott M
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- Tate M
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- Templeton M
- Terrill L
- Thomas A
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- Thomas V
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- Thrush J
- Thurairatnam S
- Tierney C
- Tinmouth A
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- Tomlinson H
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- Tong S
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- Tsakiridou K
- Tsang J
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- Turner-Bone I
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- TV B
- Udayanga I
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- Umrani Z
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- Van Nieuwkoop K
- Van Oosten N
- Van Zanten A
- Van Zuylen T
- Vanjak C
- Vanmali P
- Van Beurden M
- Van Kimmenade R
- Van Opdorp M
- Van Vonderen M
- Van’t Hoff W
- Vargas Jr. J
- Varghese S
- Vautier S
- Vazquez-Grande G
- Veenith T
- Venkatesh B
- Verheij H
- Verlander M
- Vermassen J
- Vermeiren D
- Verrier N
- Vertue M
- Verula J
- Victor S
- Viehman A
- Vieillard-Baron A
- Vignesh C
- Vincent R
- Virdee S
- Visser Y
- Vita T
- Vodovar D
- Voicu S
- Voigt I
- Voiriot G
- Voza A
- Vrolijk L
- Vuylsteke A
- Wahl N
- Waite A
- Walden A
- Walker G
- Walker R
- Walker S
- Walsh J
- Walsh L
- Walsh T
- Walsham J
- Wang S
- Ward G
- Ward K
- Ward L
- Warnapura L
- Warnock M
- Watchorn O
- Waters A
- Waterson S
- Watkins C
- Watpool I
- Watts A
- Waugh V
- Webb SA
- Weber L
- Weerasinghe T
- Weismann D
- Weiss D
- Weissman A
- Wells C
- Welters I
- Westlake S
- Wetherill B
- Wetzold R
- Whileman A
- Whitbread J
- White A
- White H
- White I
- White K
- Whitehead C
- Whitehouse T
- Wibrow B
- Wigbers J
- Wilby E
- Wilcox E
- Wilcox L
- Wild H
- Wild L
- Wilding L
- Wiles M
- Wiley D
- Wilhelmsen E
- Wilkinson D
- Willams F
- Williams A
- Williams A
- Williams A
- Williams E
- Williams G
- Williams H
- Williams K
- Williams P
- Williams P
- Williams T
- Williams V
- Williamson D
- Williamson JD
- Willis J
- Willson J
- Wilson A
- Wilson C
- Wilson M
- Winters J
- Winters L
- Wise M
- Wiseman S
- Wisniewski M
- Wittenberg W
- Wnuk C
- Woelke A
- Wong H
- Wong O
- Wood E
- Wood H
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- Woods J
- Woods L
- Worner R
- Wren J
- Wren L
- Wrey Brown C
- Wright C
- Wunderley R
- Wyatt R
- Wylie K
- Xavier K
- Yang Y
- Yarad E
- Yates D
- Yealy D
- Young C
- Young I
- Young M
- Young P
- Youngstein T
- Yu H
- Yusuff H
- Zaharia M
- Zaidi A
- Zaki A
- Zaman M
- Zapalac M
- Zarychanski R
- Zhao X
- Zinzoni V
- Zitter L
- Zouita L
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 30/11/2022
- Field of study
Importance The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. Objective To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. Design, Setting, and Participants Prespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022. Interventions Patients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401). Main Outcomes and Measures The main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83. Results Among 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies. Conclusions and Relevance Among critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months
Splicing of precursors to mRNA in higher plants: mechanism, regulation and sub-nuclear organisation of the spliceosomal machinery
- Author
- A Barta
- A Gierl
- A Kr�mer
- A Lavigueur
- A Magrelli
- A Mayeda
- A Newman
- A Newman
- A Pereira
- A Peterhans
- A Tanaka
- AF Beven
- AG Hunt
- AG Matera
- AG Matera
- AH Christensen
- AI Lamond
- AI Lamond
- AI Lamond
- AJ McCullough
- AJ McCullough
- AL Beyer
- AM MacMillan
- AM Weiner
- AM Zahler
- AM Zahler
- AR Krainer
- ASN Reddy
- B Keith
- B Ruskin
- B Schwer
- B Schwer
- B Seraphin
- B Seraphin
- B Seraphin
- BA Hanley
- BC Rymond
- BE Hoffman
- BJ Blencowe
- BJ Blencowe
- BL Robberson
- BL Ruis
- BM Orozco
- BM Turner
- BT Luck
- C Calvio
- C Csank
- C Dean
- C Maas
- C Oubridge
- C-H Lin
- CC Query
- CF Lesser
- CF Weil
- CG Simpson
- CG Simpson
- CG Simpson
- CG Simpson
- CWJ Smith
- CWJ Smith
- CWJ Smith
- D Bradley
- D Herschlag
- D Mascarenhas
- D Nesic
- D Solnick
- D Staknis
- DA Jackson
- DA Wassarmann
- DB Bregman
- DE Tsai
- DF Oritz
- DG Wansink
- DJ Field
- DJ Leader
- DL Spector
- DR Gallie
- E Birney
- E Czarnecka
- E Grotewold
- E Izaurralde
- E Izaurralde
- E Waigmann
- EJ Sontheimer
- ES Maxwell
- F Carvalho Niebel de
- F Puvion-Dutilleul
- F Solymosy
- FV Fuller-Pace
- G Chanfreau
- G Dreyfuss
- G Lazar
- G Zhang
- GG Simpson
- GG Simpson
- GH Cardon
- GJ Goodall
- GJ Goodall
- GJ Goodall
- GJ Goodall
- GP Accotto
- H Chamberland
- H Fu
- H Fu
- H Fu
- H Kulesza
- H Li
- H Lou
- H Lou
- H Min
- H Neel
- H Sawa
- H Thiessen
- H-X Liu
- H-X Liu
- HD Madhani
- HD Madhani
- HJ Schalk
- HJ Yost
- I Raska
- I Raska
- IW Mattaj
- J Arenas
- J Callis
- J F�tterer
- J G�rlach
- J Nash
- J Nash
- J Potashkin
- J Sheen
- J Valcarel
- J Winter
- J Wuarin
- J Xue
- J-F Gui
- J-L Giranton
- JA Ferreira
- JA Wise
- JA Wu
- JC Carle-Urioste
- JC Stein
- JD Beggs
- JD Crispino
- JD Crispino
- JD Kohtz
- JE Mermoud
- JG Gall
- JG Lafontaine
- JG Lafontaine
- JG Lafontaine
- JG Umen
- JM Werneke
- JR Wyatt
- JS Sun
- JV Wu
- JWS Brown
- JWS Brown
- K Bohmann
- K Brasch
- K Hartmuth
- K Montag
- K Wiebauer
- KB Chapman
- KJ M�ller
- KK Nelson
- KK Nelson
- KP Smith
- KR Luehrsen
- KR Luehrsen
- KR Luehrsen
- KR Roesler
- KT Tycowski
- KW Osteryoung
- L Nussaume
- LE Andrade
- LE Andrade
- LE Maquat
- LF Jim�nez-Garc�a
- LM Williams
- LM Williams
- LP Eperon
- M Aebi
- M Bennet
- M Bennet
- M Carmo-Fonseca
- M Carmo-Fonseca
- M Carmo-Fonseca
- M Caromo-Fonseca
- M Frey
- M Gniadkowski
- M Hayashi
- M Malatesta
- M Niwa
- M Niwa
- M Niwa
- M Niwa
- M Ohno
- M Peletier
- M Plumpton
- M Rosbash
- M Tamaoki
- M Tian
- M Zhang
- MA Dietrich
- MA Medina
- MB Roth
- MB Roth
- MC Risue�o
- MCP Glyn
- MD Purugganan
- ME Chaboute
- MJ Moore
- MJ Varagona
- MM Konarska
- MR Frey
- MS Swanson
- MT Huang
- N Abovich
- N Hopf
- O Gozani
- O Gozani
- O White
- P Dangeard
- P Eftimiu-Heim
- P Masson
- PA Sharp
- PD Zamore
- PD Zamore
- PE Hodges
- PG Korning
- PJ Shaw
- PM Mullineaux
- PP Chee
- PW Barlow
- PW Barlow
- Q Sun
- R Conrad
- R Conrad
- R Larkin
- R Parker
- R Parker
- R Reed
- R Singh
- RA Parker
- RF Roscigno
- RJ Hershberger
- RJ Okagaki
- RL Ochs
- RM Sinibaldi
- RT O'Keefe
- S Fakan
- S Kandels-Lewis
- S Kopriva
- S Lopato
- S Michaud
- S Moreno D�az de la Espina
- S Moreno D�az de la Espina
- S Moreno D�az de la Espina
- S Sato
- S Wessler
- SC Connelly
- SE Wells
- SG Lazarowitz
- SG Lazarowitz
- SH Kim
- SJ Rundle
- SL Hall
- SM Berget
- SM Burgess
- SM Burgess
- SM Mount
- SR Norris
- T Hirose
- T Kiss
- T Lugert
- T Takahashi
- T Tantikanjana
- T Yoshimatsu
- T Zhuang
- TW Nilsen
- U Bond
- UT Meier
- V Delorme
- V Goguel
- V Kumar
- V Pautot
- V Vasil
- VL Santen van
- W Filipowicz
- W Filipowicz
- W Keller
- W-Y Tarn
- W-Y Tarn
- W-Y Tarn
- WC Boelens
- X-D Fu
- X-D Fu
- X-D Fu
- Y Xing
- Y Zhuang
- Y Zhuang
- YD Choi
- Z Kiss-L�szl�
- Z Palfi
- Z Zachar
- Z-Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study