Yes, I Am Ready Now: Differential Effects of Paced versus Unpaced Mating on Anxiety and Central Oxytocin Release in Female Rats

Sexual activity and partner intimacy results in several positive consequences in the context of stress-coping, both in males and females, such as reduced state anxiety in male rats after successful mating. However, in female rats, mating is a rewarding experience only when the estrous female is able to control sexual interactions, i.e., under paced-mating conditions. Here, we demonstrate that sex-steroid priming required for female mating is anxiolytic; subsequent sexual activity under paced mating conditions did not disrupt this anxiolytic priming effect, whereas mating under unpaced conditions increased anxiety-related behavior. In primed females, the release of the neuropeptide oxytocin (OT) within the hypothalamic paraventricular nucleus was found to be elevated and to further increase during paced, but not unpaced mating. Central administration of an OT receptor antagonist partly prevented priming/mating-induced anxiolysis indicating the involvement of brain OT in the anxiolysis triggered by priming and/or sexual activity

Long-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity

Long term time-lapse imaging reveals that individual synapses undergo significant structural remodeling not only when driven by activity, but also when network activity is absent, raising questions about how reliably individual synapses maintain connections

Postpartum psychiatric disorders

Pregnancy is a complex and vulnerable period that presents a number of challenges to women, including the development of postpartum psychiatric disorders (PPDs). These disorders can include postpartum depression and anxiety, which are relatively common, and the rare but more severe postpartum psychosis. In addition, other PPDs can include obsessive–compulsive disorder, post-traumatic stress disorder and eating disorders. The aetiology of PPDs is a complex interaction of psychological, social and biological factors, in addition to genetic and environmental factors. The goals of treating postpartum mental illness are reducing maternal symptoms and supporting maternal–child and family functioning. Women and their families should receive psychoeducation about the illness, including evidence-based discussions about the risks and benefits of each treatment option. Developing effective strategies in global settings that allow the delivery of targeted therapies to women with different clinical phenotypes and severities of PPDs is essential

Intrinsic programs regulating dendrites and synapses in the upper layer neurons of the cortex

Dendrites and spines are key regulators of neuronal function often affected in cognitive disorders. Neuronal subclasses are characterized by a wide range of dendritic morphologies that aid their specific functions. However, how subclass-specific dendritic trees arise during vertebrate development remains largely unknown. We have recently reported that the restricted expression of Cux1 and Cux2 genes in the upper layers of the cerebral cortex determines the specific morphology of dendrites and spines and the function of these neurons. Since Cux genes are the vertebrate homologs of Drosophila Cut, which specifies the dendritic morphologies of certain sensory neuron populations, our findings suggest that mechanisms of dendrite differentiation are conserved between Drosophila and mammals, which had yet to be demonstrated. Importantly, we found that Cux genes not only modulate dendritic branching, but also dendritic spine morphogenesis, the functional synapse and cognition. Dendritic spine stabilization was partly mediated by direct repression of genes of the Xlr family, previously implicated in cognitive defects in a model of Turner syndrome. Hence, our work indicates that neuronal subclass specific determinants may intrinsically affect synaptic activity beyond expected. The functions of Cux1 and Cux2 were additive and complement each other to establish the final pattern of the dendritic tree and the number and strength of the synapses. This work unravels novel mechanisms of dendritogenesis and synaptogenesis and illustrates how regulating dendritic structures contributes to the specialization of upper layer neurons. It will be interesting to dissect how these mechanisms regulate cortical activity, area specialization and cognitive functions