STUDIES AND RESEARCH CONCERNING THE USE OF SOME RECYCLABLE ABSORBENT MATERIALS FOR INCREASING ACOUSTIC COMFORT INTO A ROOM DESIGNED FOR SPEAKING

The acoustic comfort of a speech hall is characterized by acoustic parameters. These parameters depend by on the hall volume, construction and design materials. On the hall ceiling (the most unused surface), some various acoustic devices can be installed on which the acoustic materials can be applied in order to obtain specific suitable acoustic parameters for that hall. Recycled materials such as wood, granular recycled rubber, shredded recycled plastic and shredded polypropylene, applied on various acoustic devices made from OAS, polystyrene or plasterboard rigips, can increase the acoustics quality of room

A GREEN APPROACH FOR THE SELECTIVE REDUCTION OF AROMATIC CARBONYL COMPOUNDS USING RANEY Ni-Al ALLOY

Given the significant environmental risk associated with the use of organic solvents and catalysts in the classic reduction reaction catalysts, we are interested in adapting the reaction medium and in developing an eco-friendly methodology for the synthesis of corresponding alcohols in reasonably yields. In this study, the reduction of some aromatic carbonyl compounds with Ni-Al alloy in aqueous alkaline medium was carried out in two versions: with 20 wt% aq NaOH and with 1 wt% aq NaOH without organic solvent. The structures of the reaction products are rigorously proven by gas chromatography-mass spectrometry (GC-MS). There was observed an increase of the reduction reaction rate when we used 1 wt% aq NaOH without addition of organic solvent. For a good part of the studied substrates high conversion and selectivity were achieved by employing mild reaction conditions, minimal environmental pollution and simple work up procedure, foreshadowing yields above 90 % and representing candidates for convenient preparative applications

PHYSICOCHEMICAL CHARACTERIZATION AND ACCEPTABILITY OF SOME ARTISANAL MINT LIQUEURS

The medicinal herb Mentha piperita L. has been used for hundreds of years for its remarkable medicinal properties. Due to its composition rich in essential oil, terpenes, flavonoids etc., the peppermint is commonly used in various fields for obtaining cosmetics, medicines, and also in the food industry. The aim of the present study consisted in developing accessible recipes for preparation of artisanal dessert mint liqueurs by different extraction variants and determining their physicochemical and sensory analyses. Four types of mint liqueurs were prepared by maceration of peppermint leaves in alcohol, varying the extraction parameters: time, temperature or by changing the order of ingredients addition. For the obtained artisanal liqueurs samples the following physicochemical characteristics were determined: dry extract, alcoholic strength, soluble solids, total acidity, fixed acidity, volatile acidity, density, conductivity and refractive index. The samples prepared were organoleptically analyzed by a multi-sensory approach (appearance and clarity, color, odor and aroma, taste) using the scoring method and the results revealed that the artisanal liqueurs obtained are well accepted by the consumers

DIHYDRODIPYRIDOPYRAZINES: SYNTHESIS AND FUNCTIONALIZATION

Different conceptual synthetic approaches to the elaboration of a new family of planar polynuclear nitrogen containing aromatic heterocycles – the dihydrodipyridopyrazines – are reviewed: the arynic reaction, the sequence palladium coupling reaction - substitution - reduction - cyclization - substitution or through the intermediacy of Smiles rearrangement. Further functionalization of these compounds by substitution reaction, metalation sequence and palladium-catalyzed coupling reaction are also discussed

Cytotoxic evaluation of original pyrazolo[3,4-d]thiazoles and pyrazolo[3,4-c]pyrazoles

International audienceA concise and versatile synthetic strategy for the synthesis of original substituted heterobicycles was developed, relying on the use of aromatic hydrazines in one-pot condensations and Ullmann-type intramolecular cyclization sequences, as well as on chemoselective brominations and palladium-mediated cross-coupling reactions. In this study, the two series of novel heterobicycles were tested for their cytotoxic potential. The compounds were structurally characterized by nuclear magnetic resonance spectrometry (1H NMR and 13C NMR), infrared spectroscopy (IR) and high-resolution mass spectrometry (HRMS). The IC50 values of these compounds on five tumour cell lines (A-549, HS-683, MCF-7, SK-MEL-28 and B16-F1) were obtained by MTT colorimetric assay. Six of the compounds exhibited excellent activity compared to 5-fluorouracil against two of the five cell lines tested, with IC50 values ranging from 0.1 to 10 μM