4,085 research outputs found

    Searching a biomedical database from Bulgaria : the ABS database

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    The University of Sofia, Bulgaria, disseminates local biomedical literature (1994 to present) through a free online database, ABS. We systematically searched ABS to identify citations to controlled trials and find what proportion of these studies are to be found on MEDLINE. We searched using Bulgarian and English phrases; manually selected citations of controlled trials and sought these citations on MEDLINE. Using the two languages we found a total of 628 unique citations, of which 47 of which seem to be relevant controlled trials (precision 7.48%, 13% of ABS citations were found on MEDLINE). The trials in ABS commonly focused on evaluation of care for people with cardiovascular or urological problems

    Searching a biomedical database from Bulgaria : the ABS database

    Get PDF
    The University of Sofia, Bulgaria, disseminates local biomedical literature (1994 to present) through a free online database, ABS. We systematically searched ABS to identify citations to controlled trials and find what proportion of these studies are to be found on MEDLINE. We searched using Bulgarian and English phrases; manually selected citations of controlled trials and sought these citations on MEDLINE. Using the two languages we found a total of 628 unique citations, of which 47 of which seem to be relevant controlled trials (precision 7.48%, 13% of ABS citations were found on MEDLINE). The trials in ABS commonly focused on evaluation of care for people with cardiovascular or urological problems

    Examination of actin and microtubule dependent APC localisations in living mammalian cells

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    Abstract (provisional) Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular junctions has been previously presented, though live imaging of mammalian junctional APC has not been documented. Results Using live imaging of transfected COS-7 cells we observed intercellular junction-associated pools of GFP-APC in addition to previously documented microtubule-associated GFP-APC and a variety of minor localisations. Although both microtubule and junction-associated populations could co-exist within individual cells, they differed in their subcellular location, dynamic behaviour and sensitivity to cytoskeletal poisons. GFP-APC deletion mutant analysis indicated that a protein truncated immediately after the APC armadillo repeat domain retained the ability to localise to adhesive membranes in transfected cells. Supporting this, we also observed junctional APC immunostaining in cultures of human colorectal cancer cell line that express truncated forms of APC. Conclusions Our data indicate that APC can be found in two spatially separate populations at the cell periphery and these populations can co-exist in the same cell. The first localisation is highly dynamic and associated with microtubules near free edges and in cell vertices, while the second is comparatively static and is closely associated with actin at sites of cell-cell contact. Our imaging confirms that human GFP-APC possesses many of the localisations and behaviours previously seen by live imaging of Xenopus GFP-APC. However, we report the novel finding that GFP-APC puncta can remain associated with the ends of shrinking microtubules. Deletion analysis indicated that the N-terminal region of the APC protein mediated its junctional localisation, consistent with our observation that truncated APC proteins in colon cancer cell lines are still capable of localising to the cell cortex. This may have implications for the development of colorectal cancer

    Designing Good Partial Coverage Satellite Constellations

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    Design of satellite constellations providing partial coverage of certain ground regions is becoming more important as small low-altitude satellites receive increased attention. The purpose of this study is to develop the procedures necessary for deriving the best constellations for partial coverage

    Secondary Intervention After Endovascular Abdominal Aortic Aneurysm Repair

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    Lower bound for energies of harmonic tangent unit-vector fields on convex polyhedra

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    We derive a lower bound for energies of harmonic maps of convex polyhedra in R3 \R^3 to the unit sphere S2,S^2, with tangent boundary conditions on the faces. We also establish that C∞C^\infty maps, satisfying tangent boundary conditions, are dense with respect to the Sobolev norm, in the space of continuous tangent maps of finite energy.Comment: Acknowledgment added, typos removed, minor correction
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