Stabilnost amlodipin besilata i atenolola u jednoslojnim i dvoslojnim tabletama

Multi-drug tablets of amlodipine besylate and atenolol were prepared as either mono-layer (mixed matrix) or bi-layer tablets containing each drug in a separate layer by using similar excipients and processing. Each tablet batch was packed in strip and blister packs and kept under accelerated temperature and humidity conditions. The stability of two tablet and packaging types was compared by HPLC analysis after 0, 1, 3 and 4.5 months and expressed as the content of intact amlodipine and atenolol. The content of atenolol did not decline regardless of tablet and packaging type. Amlodipine content in bi-layer tablets decreased to about 95 and 88% when packed in strips and blisters, respectively. When prepared as mono-layer tablets, the content decreased to 72 and 32%, respectively. The study revealed that the bi-layer tablet formulation was more stable than the mono-layer type. Further, the stability was increased when the tablets were packed in aluminium strips as compared to PVC blisters.Tablete s amlodipinom i atenololom pripremljene su ili u obliku jednoslojne tablete (miješani matriks) ili kao dvoslojne tablete (lijekovi u zasebnim slojevima) koristeći slične pomoćne tvari i uvjete tabletiranja. Tablete su pakirane u dvije vrste pakiranja, aluminijske folije (strip) ili PVC (blister) i čuvane u uvjetima ubrzanog starenja. Stabilnost je određivana pomoću HPLC metode nakon 0, 1, 2, 3 i 4,5 mjeseci i izražena kao sadržaj intaktnog lijeka. Sadržaj atenolola nije se značajno promijenio bez obzira na tip tablete ili pakiranje. Sadržaj amlodipina u dvoslojnim tabletama smanjio se na 95 % (tablete u strip pakiranju) i 88 % (tablete u blister pakiranju). Istodobno, u jednoslojnom tipu kombiniranih tableta sadržaj se smanjio na 72 % (strip pakiranje) i 32 % (blister pakiranje). Rezultati pokazuju da su dvoslojne tablete s amlodipinom i atenololom stabilnije od jednoslojnih. Štoviše, pakiranje tableta u aluminijsku foliju u obliku strip pakiranja povećava njihovu stabilnost u usporedbi s PVC pakirnim materijalom (blister)

A hirshfeld surface analysis and crystal structure of 2'-1-(2-fluoro-phenyl)-1H-tetrazol-5-Yl-4-methoxy-biphenyl-2-carbaldehyde

The title compound, C21H15FN4O2 is synthesized and characterized by 1 H NMR, LC-MS and finally confirmed by single crystal X-ray diffraction method. This molecule crystallizes in the monoclinic crystal system and space group P21/c, with crystal parameters a = 9.4386(5) Å, b = 20.8082(1) Å, c = 9.4338(6) Å, β = 99.566(2)0 , Z = 4 and V = 1826.98(19) Å3 . The mean planes of fluro-phenyl moiety makes a dihedral angle of 21.51 (7)0 with biphenyl moiety. The molecules are connected by hydrogen bonds of the type C---H...O and C---H...F. In addition, crystal structure is stabilized with π … π (exhibits intramolecular interaction) and C---O... π interactions. The intercontacts in the crystal structure are analyzed using Hirshfeld surfaces computational method

(E)-1-(5-Chloro­thio­phen-2-yl)-3-(2,4-di­methyl­phen­yl)prop-2-en-1-one

In the title compound, C\sb 15H\sb 13ClOS, the olefinic double bond adopts an \it E configuration. The mol\-ecule is nearly planar, as seen by the dihedral angle of 9.07(8)\circ between the thio\-phene and phenyl rings. The \it trans configuration of the C=C double bond in the central enone group is confirmed by the C—-C=C—-C torsion angle of 177.6(2)\circ. In the crystal, mol\-ecules are linked by weak C—-H⋅sO and C—-H⋅sS hydrogen bonds, forming chains propagating along the \it c axis

Crystal structure of 3-(thiophen-2-yl)-5-p-tolyl-4,5-dihydro-1H-pyrazole-1-carbothioamide

In the title compound, C15H15N3S2, the central pyrazole ring adopts a twisted conformation on the -CH-CH2-bond. Its mean plane makes dihedral angles of 7.19 (12) and 71.13 (11)degrees with those of the thiophene and toluene rings, respectively. The carbothiamide group C(=S)-N] is inclined to the pyrazole ring mean plane by 16.8 (2)degrees. In the crystal, molecules are linked by N-H center dot center dot center dot S hydrogen bonds, forming chains propagating along 010]. Within the chains, there are N-H center dot center dot center dot pi interactions present. Between the chains there are weak parallel slipped pi-pi interactions involving inversion-related thiophene and pyrazole rings inter-centroid distance = 3.7516 (14) angstrom; inter-planar distance = 3.5987 (10) angstrom; slippage = 1.06 angstrom]

Crystal structures of isomeric 4-bromo-\it N-(2-nitro{\-}phen{\-}yl)sulfon{\-}ylbenzamide and 4-bromo-{\it N}-(4-nitro{\-}phen{\-}yl)sulfon{\-}ylbenzamide

The syntheses and crystal structures of the isomeric 4-bromo-\it N-(2-nitro{\-}phen{\-}yl)sulfon{\-}ylbenzamide, (I), and 4-bromo-{\it N}-(4-nitro{\-}phen{\-}yl)sulfon{\-}ylbenzamide, (II), are described (mol{\-}ecular formula = C{\sb 13}H{\sb 9}BrN{\sb 2}O{\sb 5}S in each case). The asymmetric unit of (I) contains two independent mol{\-}ecules (I{\it A}) and (I{\it B}), while that of (II) contains one mol{\-}ecule. The benzoic acid aromatic ring of mol{\-}ecule (I{\it A}) is disordered due to rotation about the C{\sb ar}{---}C(=O) bond over two orientations in a 0.525(9):0.475(9) ratio. The dihedral angle between the benzene rings is 85.9(3){$^\circ$} in (I{\it A}) and 65.22(19){$^\circ$} in (I{\it B}), while in (II), the corresponding value is 56.7(7){$^\circ$}. In the crystals of (I) and (II), N{---}H{$\cdots$}O, C{---}H{$\cdots$}O and C{---}H{$\cdots$}{$\pi$} inter{\-}actions generate three-dimensional networks

4-Iodo-N-(o-tolyl­sulfon­yl)benzamide

The title compound, C\sb 14H\sb 12INO\sb 3S, crystallizes with two independent mol\-ecules (\it A and \it B) in the asymmetric unit. The dihedral angle between the two aryl rings is 83.1(4)\circ in mol\-ecule \it A and 79.8(4)\circ in mol\-ecule \it B. In the crystal, the two mol\-ecules are linked by a pair of N—-H⋅sO hydrogen bonds, forming an \it A—\it B dimer with an \it R\sb 2\sp 2(8) ring motif. The dimer is further strengthened by a pair of C—-H⋅sO hydrogen bonds with an \it R\sb 2\sp 2(14) motif. Another pair of C—-H⋅sO inter\-actions assembles these dimers along the diagonal of the \it bc plane, forming ribbons. Adjacent ribbons are connected by C—-H⋅sπ\sb ar\-yl inter\-actions between the \it A mol\-ecules, and thus the overall supra\-molecular architecture is one-dimensional

Synthesis, crystal structure, and characterization of (z)-2-(3-chlorophenyl)-n'-hydroxyacetamidine

The compound (Z)-2-(3-chlorophenyl)-N'-hydroxyacetamidine, (2) was synthesized and characterized by H-1 NMR, FT-IR, TGA, UV-Visible Spectra, and elemental analysis. Its molecular structure was solved by single-crystal X-ray diffraction method. The title molecule, C8H9ClN2O is crystallized in the monoclinic crystal system with the space group P2(1)/c and with unit cell parameters a = 8.7092(4) angstrom, b = 8.2370(4) angstrom, c = 12.5256(6) angstrom, beta = 102.252(3)degrees, and Z = 4. The molecular and crystal structure of the title molecule is stabilized by an intramolecular interaction of the type N-HcccO, and the intermolecular interactions of types N-HcccN and O-HcccN