Neonatal COVID-19 Pneumonia: Report of the First Case in a Preterm Neonate in Mayotte, an Overseas Department of France

We report the first case of COVID-19 pneumonia in a preterm neonate in Mayotte, an overseas department of France. The newborn developed an acute respiratory distress by 14 days of life with bilateral ground glass opacities on a chest CT scan and a 6-week-long stay in the neonatal intensive care unit (NICU). This case report emphasizes the need for a cautious and close follow-up period for asymptomatic neonates born to mothers with COVID-19 infection. Vertical transmission cannot be excluded in this case

Surveillance échographique au long cours de 137 enfants traités par anthracyclines

REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Analyse échocardio-graphique du ventricule droit

Le ventricule droit (VD) est essentiel à la physiologie et la physiopathologie cardiopulmonaires. La présence d’une dysfonction systolique du VD est un élément pronostique à prendre en compte dans la prise en charge des patients atteints d’infarctus du myocarde (IDM) inferieur, de valvulopathies significatives, de cardiopathies congénitales, d’hypertension artérielle pulmonaire (HTAP) et chez les patients en insuffisance cardiaque aiguë ou chronique. L’analyse du VD repose sur une approche non invasive (échocardiographie-Doppler, méthode isotopique, imagerie par résonance magnétique cardiaque) et/ou invasive (cathétérisme cardiaque droit). Longtemps négligée en échocardiographie, l’analyse du VD a le vent en poupe avec l’arrivée de nouvelles technologies d’imagerie : doppler tissulaire myocardique, strain imaging et 2D speckle tracking. Ce travail résume et discute les paramètres d’analyse du VD en échocardiographie-Doppler

Fatal Meningitis from Shiga Toxin–Producing Escherichia coli in 2 Full-Term Neonates, France

We report fatal meningitis in 2 neonates in France caused by Shiga toxin 1–producing Escherichia coli. Virulence factors capsular K1 antigen and salmochelin were present in both strains, potentially representing a new hybrid pathotype. Clinicians should remain aware of emerging pathotypes and design therapeutic strategies for neonatal E. coli infections

Maternal and congenital toxoplasmosis in Mayotte: Prevalence, incidence and management.

BackgroundToxoplasmosis is an infection caused by an intracellular protozoan, Toxoplasma gondii. It is usually asymptomatic, but toxoplasmosis acquired during pregnancy can cause congenital toxoplasmosis, potentially resulting in fetal damage. Epidemiological information is lacking for toxoplasmosis in Mayotte (a French overseas territory). We evaluated (1) the prevalence of maternal toxoplasmosis, (2) the incidence of maternal and congenital toxoplasmosis, and (3) the management of congenital toxoplasmosis in Mayotte.Methodology / principal findingsWe collected all the available data for toxoplasmosis serological screening during pregnancy and maternal and congenital cases of toxoplasmosis obtained between January 2017 and August 2019 at the central public laboratory of Mayotte (Mamoudzou). Using toxoplasmosis serological data from samples collected from 16,952 pregnant women we estimated the prevalence of toxoplasmosis in Mayotte at 67.19%. Minimum maternal toxoplasmosis incidence was estimated at 0.29% (49/16,952, 95% CI (0.0022-0.0038)), based on confirmed cases of maternal primary infection only. The estimated incidence of congenital toxoplasmosis was 0.09% (16/16,952, 95% CI (0.0005-0.0015). Missing data made it difficult to evaluate management, but follow-up was better for mothers with confirmed primary infection and their infants.Conclusions / significanceThe seroprevalence of toxoplasmosis among pregnant women and the incidence of toxoplasmosis are higher in Mayotte than in mainland France. There is a need to improve the antenatal toxoplasmosis screening and prevention programme, providing better information to physicians and the population, to improve management and epidemiological monitoring

Classification of maternal toxoplasmosis with primary infection.

Classification according to the recommendations of the French National Reference Centre for Toxoplasmosis [9,18,19].</p

Biological data, treatment and imaging information for infants born to women with confirmed toxoplasmosis, possible <i>Toxoplasma</i> infection or non-excluded primary infection.

Two sets of twins were born, one to a mother with confirmed toxoplasmosis and the other to a mother with non-excluded primary infection.</p

Demographic and management data for pregnant women with confirmed toxoplasmosis, possible <i>Toxoplasma</i> infection and non-excluded primary infection.

* Abnormalities related to congenital toxoplasmosis.</p

Diagnosis algorithm for congenital toxoplasmosis.

BackgroundToxoplasmosis is an infection caused by an intracellular protozoan, Toxoplasma gondii. It is usually asymptomatic, but toxoplasmosis acquired during pregnancy can cause congenital toxoplasmosis, potentially resulting in fetal damage. Epidemiological information is lacking for toxoplasmosis in Mayotte (a French overseas territory). We evaluated (1) the prevalence of maternal toxoplasmosis, (2) the incidence of maternal and congenital toxoplasmosis, and (3) the management of congenital toxoplasmosis in Mayotte.Methodology / Principal FindingsWe collected all the available data for toxoplasmosis serological screening during pregnancy and maternal and congenital cases of toxoplasmosis obtained between January 2017 and August 2019 at the central public laboratory of Mayotte (Mamoudzou). Using toxoplasmosis serological data from samples collected from 16,952 pregnant women we estimated the prevalence of toxoplasmosis in Mayotte at 67.19%. Minimum maternal toxoplasmosis incidence was estimated at 0.29% (49/16,952, 95% CI (0.0022–0.0038)), based on confirmed cases of maternal primary infection only. The estimated incidence of congenital toxoplasmosis was 0.09% (16/16,952, 95% CI (0.0005–0.0015). Missing data made it difficult to evaluate management, but follow-up was better for mothers with confirmed primary infection and their infants.Conclusions / SignificanceThe seroprevalence of toxoplasmosis among pregnant women and the incidence of toxoplasmosis are higher in Mayotte than in mainland France. There is a need to improve the antenatal toxoplasmosis screening and prevention programme, providing better information to physicians and the population, to improve management and epidemiological monitoring.</div

Management of newborns with confirmed congenital infection (CT).

*Abnormalities related to congenital toxoplasmosis. (Imaging abnormality: one case with small subependymal haemorrhages typical of toxoplasmosis (no calcification and no ventricular dilation) confirmed on check-up imaging and one case of persistent microcysts in the caudate nucleus).</p