Long term effects of aqueous stem bark extract of Cissus populnea (Guill. and Per.) on some biochemical parameters in normal rabbits

In vivo clinical trials involving oral daily administration of crude aqueous extracts of cissus populnea to grouped sprague-dawley rabbits at two dose levels of 200 and 600 gkg-1 body weight over a 60 day study period revealed that continuous exposure of the plant extract had no damaging effects on the organs of xenobiotic metabolism (liver and kidney). results of levels of serum ast, alt, alkaline phosphatase, creatinine, bilirubin and triglycerides of the two groups were not significantly different (p£ 0.05) at the end of the study from those of the control group

Preliminary study into the long term effects of a hypoglycaemic polyherbal formula (Yem-Kem) on some biochemical parameters in normal rabbits

The blood glucose lowering capacity of the polyherbal formula (Yem-Kem) was investigated in this study in an in vivo clinical trial using normal Sprague-Dawley rabbits orally administered with the formula over a 60 day period. The results showed that continuous exposure to the extract resulted in an overall lowered blood glucose level, lowered body weight and serum triglycerides, an increased alkaline phosphatase level, and fairly stable bilirubin levels. The formula is efficient as a hypoglycemicformulation, but its toxicity or otherwise cannot be established by this study