Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase

9865-986

Strategic Thinking and Dimensions of Effective Leadership

WOS: 000444687500010The concept of strategic thinking, which becomes a necessity in today's management understanding, requires to think about every issue which is meaningful from strategic point of view. Leadership, on the other hand, appears to be the most important organizational variable providing a basis for this perspective. Strategic thinking provides the managers with the courage to make the right decision at the point they want to get opportunities, the convenience of gaining problem-solving skills and being able to see the big picture and identify threats. In this study, it is aimed to examine the relationship between strategic thinking and leadership and to reveal the areas of interaction according to the basic dimensions of both concepts. In the study, the conceptual framework for strategic thinking and leadership is first presented, and then the relational context is explained. It is understood that the sub-dimensions of strategic thinking and leadership variables are mutually complementary and that the strategic thinking capacity of the organization can be guided through the interaction of two variables in the framework of the findings and evaluations revealed in the study

Transcriptional regulation of hepatic lipogenesis

Fatty acid and fat synthesis in liver is a highly regulated metabolic pathway critical for energy distribution. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcription level. Transcription factors, such as USF, SREBP-1c, LXR and ChREBP play critical roles in this process. Recently, insights have been gained into how various signaling pathways regulate these transcription factors. After feeding, high blood glucose and insulin induce lipogenic genes through several pathways, including DNA-PK, aPKC and Akt-mTOR. Various transcription factors and coregulators undergo specific modifications, such as phosphorylation, acetylation, or ubiquitination, which affect their function, stability, or localization. Dysregulation of lipogenesis can contribute to hepatosteatosis, which is associated with obesity and insulin resistance