Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis

Selenium-binding protein 1 (SELENBP1) has been associated with several cancers, although its exact role is unknown. We show that SELENBP1 is a methanethiol oxidase (MTO), related to the MTO in methylotrophic bacteria, that converts methanethiol to H2O2, formaldehyde, and H2S, an activity not previously known to exist in humans. We identified mutations in SELENBP1 in five patients with cabbage-like breath odor. The malodor was attributable to high levels of methanethiol and dimethylsulfide, the main odorous compounds in their breath. Elevated urinary excretion of dimethylsulfoxide was associated with MTO deficiency. Patient fibroblasts had low SELENBP1 protein levels and were deficient in MTO enzymatic activity; these effects were reversed by lentivirus-mediated expression of wild-type SELENBP1. Selenbp1-knockout mice showed biochemical characteristics similar to those in humans. Our data reveal a potentially frequent inborn error of metabolism that results from MTO deficiency and leads to a malodor syndrome.info:eu-repo/semantics/publishedVersio

MODIS Observations of Human-Induced Changes in the Mesopotamian Marshes in Iraq

With a total area of \u3e7,750 km2, the Mesopotamian marshes near the border between Iraq and Iran provide habitats for millions of birds and most of the commercial fisheries in this region. Beginning in the 1990s, human activities such as war, dam construction, restoration, and water supply diversions significantly influenced the ecosystems. Yet, to date only a handful of reports document changes in the marshes, all using field measurements or sporadic satellite observations. Here, using long-term MODIS observations between 2000 and 2012 we quantified the annual changes and long-term trends in both the vegetation and water coverage (i.e., the areas of vegetation and water) in the Al-Hammar, Al-Huwaiza, and the Central marshes, the three major marshes in this region. In addition to seasonality, the most notable patterns are the three distinctive regimes within the observation period: the 2000–2003 regime for low coverage of both vegetation and water, the 2004–2008 regime for significantly increased coverage, and the 2009–2012 regime for reduced coverage (almost back to the 2000–2003 levels). Relative to the 2000–2003 regime, increases in the vegetation coverage during 2004–2008 ranged from 50 to \u3e100 %. It is likely that these changes are the result of human induced activities, with weather fluctuations (e.g., precipitation) playing a minor role. Continuous and sustainable monitoring through combining satellite and field measurements is required to fully understand the consequences of such changes as well as to evaluate the impacts of future restoration programs