3,062 research outputs found

    Follow-up of phase I trial of adalimumab and rosiglitazone in FSGS: III. Report of the FONT study group

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    Abstract Background Patients with resistant primary focal segmental glomerulosclerosis (FSGS) are at high risk of progression to chronic kidney disease stage V. Antifibrotic agents may slow or halt this process. We present outcomes of follow-up after a Phase I trial of adalimumab and rosiglitazone, antifibrotic drugs tested in the Novel Therapies in Resistant FSGS (FONT) study. Methods 21 patients -- 12 males and 9 females, age 16.0 Ā± 7.5 yr, and estimated GFR (GFRe) 121 Ā± 56 mL/min/1.73 m2 -- received adalimumab (n = 10), 24 mg/m2 every 14 days or rosiglitazone (n = 11), 3 mg/m2 per day for 16 weeks. The change in GFRe per month prior to entry and after completion of the Phase I trial was compared. Results 19 patients completed the 16-week FONT treatment phase. The observation period pre-FONT was 18.3 Ā± 10.2 months and 16.1 Ā± 5.7 months after the study. A similar percentage of patients, 71% and 56%, in the rosiglitazone and adalimumab cohorts, respectively, had stabilization in GFRe, defined as a reduced negative slope of the line plotting GFRe versus time without requiring renal replacement therapy after completion of the FONT treatment period (P = 0.63). Conclusion Nearly 50% of patients with resistant FSGS who receive novel antifibrotic agents may have a legacy effect with delayed deterioration in kidney function after completion of therapy. Based on this proof-of-concept preliminary study, we recommend long-term follow-up of patients enrolled in clinical trials to ascertain a more comprehensive assessment of the efficacy of experimental treatments

    Search for flavour-changing neutral currents in processes with one top quark and a photon using 81 fbāˆ’1 of pp collisions at s=13TeV with the ATLAS experiment

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    A search for flavour-changing neutral current (FCNC) events via the coupling of a top quark, a photon, and an up or charm quark is presented using 81 fbāˆ’1 of protonā€“proton collision data taken at a centre-of-mass energy of 13 TeV with the ATLAS detector at the LHC. Events with a photon, an electron or muon, a b-tagged jet, and missing transverse momentum are selected. A neural network based on kinematic variables differentiates between events from signal and background processes. The data are consistent with the background-only hypothesis, and limits are set on the strength of the tqĪ³ coupling in an effective field theory. These are also interpreted as 95% CL upper limits on the cross section for FCNC tĪ³ production via a left-handed (right-handed) tuĪ³ coupling of 36 fb (78 fb) and on the branching ratio for tā†’Ī³u of 2.8Ɨ10āˆ’5 (6.1Ɨ10āˆ’5). In addition, they are interpreted as 95% CL upper limits on the cross section for FCNC tĪ³ production via a left-handed (right-handed) tcĪ³ coupling of 40 fb (33 fb) and on the branching ratio for tā†’Ī³c of 22Ɨ10āˆ’5 (18Ɨ10āˆ’5)

    Measurement of J/Ļˆ production in association with a W Ā± boson with pp data at 8 TeV

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    A measurement of the production of a prompt J/Ļˆ meson in association with a WĀ± boson with WĀ± ā†’ Ī¼Ī½ and J/Ļˆ ā†’ Ī¼+Ī¼āˆ’ is presented for J/Ļˆ transverse momenta in the range 8.5ā€“150 GeV and rapidity |yJ/Ļˆ| < 2.1 using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton-proton centre-of-mass energy of s = 8 TeV and correspond to an integrated luminosity of 20.3 fbāˆ’1. The ratio of the prompt J/Ļˆ plus WĀ± cross-section to the inclusive WĀ± cross-section is presented as a differential measurement as a function of J/Ļˆ transverse momenta and compared with theoretical predictions using different double-parton-scattering cross-sections. [Figure not available: see fulltext.]
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