18 research outputs found

    Features of The Heart Remodeling in Patients with Chronic Obstructive Pulmonary Diseases, Combined with Coronary Heart Diseases

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    The characteristics of heart remodeling in patients with chronic obstructive pulmonary diseases ( COPD), associated with coronary heart diseases (CHD) were examined. The changes of structural and functional state of myocardium, intracardiac relationships with associated pathology were under study. The role of blood inflammatory cytokines (IL-6, IL-8, TNF-a) and the level of cell adhesion molecules (ICAM-1, VCAM-1) in exacerbating myocardial dysfunction was clarified

    Hemodynamics features and contractive miocardial function in patients with chronical obstructive pulmΠΎnΠ°ry diseases accompanied by bronchial asthma

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    Hemodynamics and contractive myocardial function features in patients with chronic obstructive pulmonary disease (OOPD) accompanied by bronchial asthma have been examined. The changes of cardiohemodynamics have been presented according to the ventilation disorders level, balance of blood cytokines (IL-4, IL-6, IL-8, TFN-a) and adhesion molecules level (IOAM-1, VOAM-1

    На ΠΏΡƒΡ‚ΠΈ ΠΊ Π°Π²Ρ‚ΠΎΠΌΠ°Ρ‚ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΌΡƒ ΠΌΠ΅Ρ‚Π°-Π°Π½Π°Π»ΠΈΠ·Ρƒ биомСдицинских тСкстов Π² области ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠΉ ΠΈΠΌΠΌΡƒΠ½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ

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    Cell-based immunotherapy is a promising approach for the treatment of chronic infections, autoimmune disorders, and malignant tumors. There are many strategies of cell-based immunotherapy of cancer; these include injection of various immune effector cells, propagated and Β«trainedΒ» in a cell culture. Alternatively, cells presenting tumor antigens on their surface in a form recognized by the immune system can be used to achieve a therapeutic effect. The research results in this field are presented in thousands of texts, and their manual analysis is very complicated. We have developed an approach for automated text analysis in this area of biomedical science. Here we present the first results of the automated analysis of the data extracted from abstracts of scientific articles available in PubMed. These results demonstrate the associations between types of tumors and the most commonly used methods of their cell-based immunotherapy.ΠšΠ»Π΅Ρ‚ΠΎΡ‡Π½Π°Ρ иммунотСрапия это пСрспСктивный ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΊ Π»Π΅Ρ‡Π΅Π½ΠΈΡŽ хроничСских ΠΈΠ½Ρ„Π΅ΠΊΡ†ΠΈΠΉ, Π°ΡƒΡ‚ΠΎΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠΉ ΠΈ злокачСствСнных ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ. БущСствуСт мноТСство стратСгий ΠΈΠΌΠΌΡƒΠ½ΠΎΡ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Ρ€Π°ΠΊΠ°, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ ΠΈΠ½ΡŠΠ΅ΠΊΡ†ΠΈΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… эффСкторных ΠΊΠ»Π΅Ρ‚ΠΎΠΊ, Ρ€Π°Π·ΠΌΠ½ΠΎΠΆΠ΅Π½Π½Ρ‹Ρ… ΠΈ Β«ΠΎΠ±ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ…Β» Π² ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠΉ ΠΊΡƒΠ»ΡŒΡ‚ΡƒΡ€Π΅. Π’ качСствС Π°Π»ΡŒΡ‚Π΅Ρ€Π½Π°Ρ‚ΠΈΠ²Ρ‹ для достиТСния тСрапСвтичСского эффСкта ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ ΠΊΠ»Π΅Ρ‚ΠΊΠΈ, ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΡŽΡ‰ΠΈΠ΅ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅Π²Ρ‹ΠΉ Π°Π½Ρ‚ΠΈΠ³Π΅Π½ Π½Π° своСй повСрхности Π² «понятном» для ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠΉ систСмы Π²ΠΈΠ΄Π΅. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ исслСдований Π² этой области прСдставлСны Π² тысячах тСкстов, Ρ€ΡƒΡ‡Π½ΠΎΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… Π·Π°Ρ‚Ρ€ΡƒΠ΄Π½Π΅Π½. ΠœΡ‹ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π»ΠΈ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ для автоматичСского Π°Π½Π°Π»ΠΈΠ·Π° тСкстов Π² этой области биомСдицинской Π½Π°ΡƒΠΊΠΈ. Π’ Π΄Π°Π½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΌΡ‹ прСдставляСм ΠΏΠ΅Ρ€Π²Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ автоматичСского Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π°Π½Π½Ρ‹Ρ…, ΠΈΠ·Π²Π»Π΅Ρ‡Π΅Π½Π½Ρ‹Ρ… ΠΈΠ· абстрактов Π½Π°ΡƒΡ‡Π½Ρ‹Ρ… статСй, доступных Π² PubMed. На корпусС ΠΈΠ·Π²Π»Π΅Ρ‡Π΅Π½Π½Ρ‹Ρ… тСкстов ΠΌΡ‹ дСмонстрируСм ассоциации ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ‚ΠΈΠΏΠ°ΠΌΠΈ ΠΎΠΏΡƒΡ…ΠΎΠ»Π΅ΠΉ ΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ часто ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅ΠΌΡ‹ΠΌΠΈ способами ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠΉ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ
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